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Figure 1: Dietary factors increase the levels of IGF1 synthesized from liver. IGF1-mediated increased signaling of androgen receptor results in increased expression of FGF7 and FGF10, the ligands of FGFR2b signaling in keratinocyte. Both the IGF1R and FGFR2b activation results in a common downstream pathway via activation of PI3/Akt, MAPK, and phospholipase C activation with resultant increase in all the three factors responsible for acne. (T- in the figure stands for testosterone)

Figure 1: Dietary factors increase the levels of IGF1 synthesized from liver. IGF1-mediated increased signaling of androgen receptor results in increased expression of FGF7 and FGF10, the ligands of FGFR2b signaling in keratinocyte. Both the IGF1R and FGFR2b activation results in a common downstream pathway via activation of PI3/Akt, MAPK, and phospholipase C activation with resultant increase in all the three factors responsible for acne. (T- in the figure stands for testosterone)