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Figure 1 :Metabolic transformation of arsenic in mammalian tissue (occurring mainly in liver cytosol system) *Glutathione (GSH) acts as donor of reducing equivalent and transforms to GSSH, †Oxidative methylation involves methyl transferases (e.g., arsenite methyl transferase) with S-adenosyl methionine acting as donor of methyl (CH3-) group. As3+: arsenite; As5+: arsenate; MMA: monomethyl arsonic acid [CH3As5+]; MMA3+: monomethyl arsonous acid [CH3As3+]; DMA: dimethyl arsinic acid [(CH3)2As3+]; GSH: glutathione; GSSH: glutathione after supplying reducing equivalent; SAM: S-adenosyl methionine; SAHC: S-adenosyl homocysteine

Figure 1 :Metabolic transformation of arsenic in mammalian tissue (occurring mainly in liver cytosol system)
*Glutathione (GSH) acts as donor of reducing equivalent and transforms to GSSH, †Oxidative methylation involves methyl transferases (e.g., arsenite methyl transferase) with S-adenosyl methionine acting as donor of methyl (CH3-) group. As3+: arsenite; As5+: arsenate; MMA: monomethyl arsonic acid [CH3As5+]; MMA3+: monomethyl arsonous acid [CH3As3+]; DMA: dimethyl arsinic acid [(CH3)2As3+]; GSH: glutathione; GSSH: glutathione after supplying reducing equivalent; SAM: S-adenosyl methionine; SAHC: S-adenosyl homocysteine