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   2016| January-February  | Volume 82 | Issue 1  
    Online since December 31, 2015

 
 
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IMAGES IN CLINICAL PRACTICE
Purple glove syndrome
Pavitra Manu Dogra, Suman Kumar Pramanik, Sebabrata Jana
January-February 2016, 82(1):107-108
DOI:10.4103/0378-6323.172908  PMID:26728832
  1 1,884 154
LETTERS TO THE EDITOR - CASE LETTERS
Pirfenidone induced phototoxic reaction in an elderly man
Rohini Pradip Gaikwad, Samipa S Mukherjee
January-February 2016, 82(1):101-103
DOI:10.4103/0378-6323.172899  PMID:26728829
  1 2,058 96
Anal canal adenocarcinoma in a patient with psoriasis treated with etanercept
Bei-Bei Yang, Xiao-Yong Man, Min Zheng
January-February 2016, 82(1):103-104
DOI:10.4103/0378-6323.171009  PMID:26728830
  1 1,699 48
BRIEF REPORT
Immunotherapy using purified protein derivative in the treatment of warts: An open uncontrolled trial
Vikrant Saoji, Nitin R Lade, Rutuja Gadegone, Arun Bhat
January-February 2016, 82(1):42-46
DOI:10.4103/0378-6323.171650  PMID:26728809
Background: Warts are known to clear spontaneously with the development of cell-mediated immunity (CMI) to the virus. Purified protein derivative (PPD) of tuberculin bacilli has been used as a non-specific stimulant of CMI to achieve this outcome. Aim: To study the effect of PPD in the treatment of warts. Methods: Patients with difficult-to-treat warts were selected for immunotherapy. Each patient received 2.5 TU of PPD intralesionally in a few warts. A total of four sessions were given at 2 weekly intervals and patients were followed up for 6 months after the last dose. Results: Sixty-one patients were recruited of which 55 completed 6 months follow up and were available for analysis. Of these, 25 had verruca vulgaris, 18 had verruca plana and 12 had plantar warts. Forty two (76%) patients showed complete clearance after four sessions while the remaining 13 (24%) patients were non-responders. One patient developed a recurrence after total clearance during the follow-up period. Adverse effects were erythema, edema and pain at the site of injections. Limitations: As this was an uncontrolled trial, there is no comparison with a non-intervention group. Also, a Mantoux test was not done due to practical difficulties. Conclusion: Immunotherapy with PPD is helpful in the treatment of cutaneous warts.
  - 9,674 461
CASE REPORTS
Atypical presentations of eosinophilic fasciitis
Tulin Ergun, Dilek Seckin, Andac Salman, Esra Sarac Ocak, Ayse Deniz Yucelten, Haner Direskeneli, Cuyan Demirkesen, Gazanfer Ekinci, Mahmut Bayik
January-February 2016, 82(1):47-52
DOI:10.4103/0378-6323.171010  PMID:26728810
Eosinophilic fasciitis is an uncommon connective tissue disease that may mimic and overlap with other sclerosing disorders such as morphea and lichen sclerosus. Herein, we report four patients (two men and two women, aged 16-64 yeas) with eosinophilic fasciitis. There was overlap with both morphea and lichen sclerosus in 2 patients and with morphoea alone in 1 patient. Magnetic resonance imaging (MRI) was used for diagnosis in three patients and for assessing treatment response in one patient. Eosinophilic fasciitis may co-exist with morhoea and lichen sclerosus. In view of the overlapping clinical and histopathological features of these disorders, MRI may be helful in delineating the conditions by detecting involvement of fascia.
  - 3,120 130
Isolated cutaneous involvement in a child with nodal anaplastic large cell lymphoma
Vibhu Mendiratta, Nikita Gandhi, Shiwangi Rana, Shailaja Shukla, Ramchander
January-February 2016, 82(1):53-56
DOI:10.4103/0378-6323.164215  PMID:26728811
Non-Hodgkin lymphoma is a common childhood T-cell and B-cell neoplasm that originates primarily from lymphoid tissue. Cutaneous involvement can be in the form of a primary extranodal lymphoma, or secondary to metastasis from a non-cutaneous location. The latter is uncommon, and isolated cutaneous involvement is rarely reported. We report a case of isolated secondary cutaneous involvement from nodal anaplastic large cell lymphoma (CD30 + and ALK +) in a 7-year-old boy who was on chemotherapy. This case is reported for its unusual clinical presentation as an acute febrile, generalized papulonodular eruption that mimicked deep fungal infection, with the absence of other foci of systemic metastasis.
  - 1,757 83
E-IJDVL - NET LETTERS
Congenital triangular alopecia: Is it always confined to fronto-temporal region?
Nidhi Singh, Ajay Goyal, Devinder Mohan Thappa, Nachiappa Ganesh Rajesh
January-February 2016, 82(1):112-112
DOI:10.4103/0378-6323.157456  PMID:26728834
  - 2,129 89
Erythrodermic pityriasis rubra pilaris: Dramatic response to infliximab therapy
Ayse Serap Karadag, Mukaddes Kavala, Emin Ozlu, Seyma Ozkanlı, İlkin Zindancı, Zafer Turkoglu
January-February 2016, 82(1):112-112
DOI:10.4103/0378-6323.157457  PMID:26728835
  - 2,713 76
Facial cellulitis and Ludwig's angina associated with calcium hydroxylapatite injection in an immunocompetent patient
Chiau-Sheng Jang, Wen-Chieh Chen, Jui-Hsun Fu, Chieh-Shan Wu, Kai-Che Wei
January-February 2016, 82(1):112-112
DOI:10.4103/0378-6323.162322  PMID:26728836
  - 2,220 53
Transient autoimmune thyroiditis associated with Sweet's syndrome
Renu Rattan, Abhishek Sharma, Vinay Shanker, Gita R Tegta, Ghanshyam K Verma
January-February 2016, 82(1):112-112
DOI:10.4103/0378-6323.162323  PMID:26728837
  - 1,595 65
Sign of Leser-Trélat in association with laryngeal carcinoma
Asha Nyati, Sarita Kalwaniya, Suresh Jain, Bajrang Soni
January-February 2016, 82(1):112-112
DOI:10.4103/0378-6323.164222  PMID:26728838
  - 1,750 63
Premature sebaceous hyperplasia with satisfactory response to oral isotretinoin
Wei Wang, Ying Qiu, Guizhi Zhou, Zhenhuan Pei, Furen Zhang
January-February 2016, 82(1):113-113
DOI:10.4103/0378-6323.162346  PMID:26728839
  - 2,665 84
IJDVL AWARDS 2015
IJDVL Awards 2015

January-February 2016, 82(1):120-120
  - 543 49
IMAGES IN CLINICAL PRACTICE
Pachydermoperiostosis
Prathima Munichandrappa, Nidhi Singh, Devinder Mohan Thappa
January-February 2016, 82(1):57-58
DOI:10.4103/0378-6323.172901  PMID:26728812
  - 1,826 147
LETTER TO THE EDITOR - THERAPY LETTER
Autologous fibroblast suspension for the treatment of refractory diabetic foot ulcer
Mohammad Ali Nilforoushzadeh, Fariba Jaffary, Mansour Siavash, Nazli Ansari, Amir Hossein Siadat, Asieh Heidari
January-February 2016, 82(1):105-106
DOI:10.4103/0378-6323.172905  PMID:26728831
  - 2,009 93
LETTERS TO THE EDITOR - CASE LETTERS
Eruptive hypomelanosis in a child, a new viral exanthem
Vijay Zawar, Pravin Bharatia, Antonio Chuh
January-February 2016, 82(1):85-86
DOI:10.4103/0378-6323.172909  PMID:26728822
  - 2,824 121
Facial involutive tumors: A case of tumor-like eosinophilic granuloma of the skin
Elizabeth Deysy Cieza-Díaz, Cristina Ciudad Blanco, José Antonio Jiménez Heffernan, Pablo Lázaro Ochaita
January-February 2016, 82(1):87-89
DOI:10.4103/0378-6323.172906  
  - 1,156 53
Erythroderma secondary to lichen planus in a child
Chitra Gupta, Surabhi Sinha, Bijaylaxmi Sahoo, Vijay Kumar Garg
January-February 2016, 82(1):89-91
DOI:10.4103/0378-6323.171654  PMID:26728824
  - 1,646 84
Linear and whorled nevoid hypermelanosis: A case report with dermoscopic findings
Enzo Errichetti, Enrico Pegolo, Giuseppe Stinco
January-February 2016, 82(1):91-93
DOI:10.4103/0378-6323.171007  PMID:26728825
  - 2,177 78
Multifocal spindle cell hemangioma: Report of two cases
Daniela Kramer, Camila Downey, Patricio Vargas, Alex Castro
January-February 2016, 82(1):93-95
DOI:10.4103/0378-6323.172907  PMID:26728826
  - 1,703 57
Angiosarcoma of the scalp and face associated with Kasabach–Merritt syndrome and disseminated intravascular coagulation
Sijian Wen, Wei Zhang, Ying Yang, Jianfang Sun
January-February 2016, 82(1):96-97
DOI:10.4103/0378-6323.172900  PMID:26728827
  - 1,714 57
Primary cutaneous anaplastic large cell lymphoma in a child simulating primary cutaneous Hodgkin's disease
Vikram K Mahajan, Rashmi Jindal
January-February 2016, 82(1):98-101
DOI:10.4103/0378-6323.171643  PMID:26728828
  - 1,632 60
LETTERS TO THE EDITOR - OBSERVATION LETTERS
Interface dermatitis without cornoid lamellae is a pitfall in the diagnosis of porokeratosis: A report of three cases
Rajiv Joshi, Lismary Mesquita
January-February 2016, 82(1):70-72
DOI:10.4103/0378-6323.162347  PMID:26728816
  - 1,833 70
Dermoscopy: A rapid bedside tool to assess monilethrix
Vinod Kumar Sharma, Minu Jose Chiramel, Ashwin Rao
January-February 2016, 82(1):73-74
DOI:10.4103/0378-6323.172910  PMID:26728817
  - 2,130 145
Agminated lentiginosis or segmental neurofibromatosis: A diagnostic challenge
Noha Mohammed Dawoud, Ola Ahmed Bakry, Marwa Mohammed Dawoud, Rehab Monir Samaka
January-February 2016, 82(1):75-77
DOI:10.4103/0378-6323.171651  PMID:26728818
  - 5,367 106
LEOPARD syndrome and multiple granular cell tumors: An underreported association?
Ignacio Hernández Aragüés, Minia Campos Domínguez, Verónica Parra Blanco, Begoña Ezquieta Zubicaray, Ricardo Suárez Fernández
January-February 2016, 82(1):77-79
DOI:10.4103/0378-6323.171642  PMID:26728819
  - 593 31
Congenital cellular plexiform schwannoma mimicking a vascular lesion: Potential pitfalls in clinical and histopathological assessment
Aruna Nambirajan, Asit R Mridha, Pawan Kumar, Ruma Ray
January-February 2016, 82(1):79-81
DOI:10.4103/0378-6323.171012  PMID:26728820
  - 1,455 61
Could co-infection with Anaplasma play a role in Borrelia-associated primary cutaneous marginal zone B-cell lymphomas?
Serena Bonin, Giuseppe Stinco, Maria Martina Patriarca, Sara Trevisini, Nicola di Meo, Giusto Trevisan
January-February 2016, 82(1):81-84
DOI:10.4103/0378-6323.171011  PMID:26728821
  - 1,741 50
LETTERS TO THE EDITOR - STUDY LETTERS
An open uncontrolled trial of topical 5-aminolevulinic acid photodynamic therapy for the treatment of urethral condylomata acuminata in male patients
Xiaofeng Shan, Na Wang, Zhongwei Li, Jianling Hou, Rongtao Zheng, Hongqing Tian, Furen Zhang
January-February 2016, 82(1):65-67
DOI:10.4103/0378-6323.171649  PMID:26728814
  - 5,330 67
What's up dermatology? A pilot survey of the use of WhatsApp in dermatology practice and case discussion among members of WhatsApp dermatology groups
Feroze Kaliyadan, KT Ashique, Soumya Jagadeesan, Boby Krishna
January-February 2016, 82(1):67-69
DOI:10.4103/0378-6323.171638  PMID:26728815
  - 3,167 114
ORIGINAL ARTICLES
Development and validation of a Hindi language health-related quality of life questionnaire for melasma in Indian patients
Rashmi Sarkar, Shilpa Garg, Arturo Dominguez, Rajesh Balkrishnan, RK Jain, Amit G Pandya
January-February 2016, 82(1):16-22
DOI:10.4103/0378-6323.168937  PMID:26728805
Background: Melasma, which is fairly common in Indians, causes significant emotional and psychological impact. A Hindi instrument would be useful to assess the impact of melasma on the quality of life in Indian patients. Objective: To create a semantic equivalent of the original MELASQOL questionnaire in Hindi and validate it. Methods: A Hindi adaptation of the original MELASQOL (Hi-MELASQOL) was prepared using previously established guidelines. After pre-testing, the Hi-MELASQOL questionnaire was administered to 100 women with melasma visiting the out-patient registration counter of Safdarjung Hospital, Delhi. These women were also administered a Hindi equivalent of the Health Related Quality of Life (HRQOL) questionnaire. Melasma area severity index (MASI) of all the participants was calculated. Results: The mean MASI score was 20.0 ± 7.5 and Hi-MELASQOL score was 37.19 ± 18.15; both were highly, positively and significantly correlated. Reliability analysis showed satisfactory results. Physical health, emotional well-being and social life were the most adversely affected life domains. Limitations: It was a single-center study and the number of patients studied could have been larger. Conclusion: Hi-MELASQOL is a reliable and validated tool to measure the quality of life in Indians with melasma.
  - 3,406 179
Viability of Mycobacterium leprae in the environment and its role in leprosy dissemination
Partha Sarathi Mohanty, Farah Naaz, Dheeraj Katara, Lama Misba, Dilip Kumar, Deepak Kumar Dwivedi, Amit Kumar Tiwari, Devendra Singh Chauhan, Avi Kumar Bansal, Srikanth Prasad Tripathy, Kiran Katoch
January-February 2016, 82(1):23-27
DOI:10.4103/0378-6323.168935  PMID:26728806
Background: Leprosy, a chronic disease caused by Mycobacterium leprae, is a public health concern in certain countries, including India. Although the prevalence of the disease has fallen drastically over time, new cases continue to occur at nearly the same rate in many regions. Several endemic pockets have been observed in India and elsewhere. The precise dynamics of leprosy transmission are still not clearly understood. Both live bacilli as well as M. leprae DNA have been detected in the soil and water of endemic areas; they possibly play an important role in disease transmission. Aims: To study the occurrence of viable M. leprae in environmental samples collected from areas of residence of patients with active leprosy. Methods: The study was conducted on 169 newly diagnosed leprosy patients in Ghatampur, Uttar Pradesh, India. Soil and water samples were collected from their areas of residence using a standardized protocol. An equal number of soil and water samples were also collected from non-patient areas of the same or adjoining villages. The environmental samples collected from the patients surroundings were subjected to 16S ribosomal RNA gene analysis after obtaining informed consent. Results: About a quarter of the environmental samples collected from patient areas, (25.4% of soil samples and 24.2% of water samples) were found to be positive for specific 16S ribosomal RNA genes of M. leprae. Environmental samples collected from non-patient areas were all found negative for M. leprae 16S ribosomal RNA genes. Limitations: The major limitation of the study was that the sample size was small. Conclusion: The study demonstrated the presence of viable strains of M. leprae in skin smear samples of paucibacillary patients and multibacillary patients, as well as in the environmental samples obtained from around their houses. This could play an important role in the continued transmission of leprosy.
  - 3,836 262
Drug reaction with eosinophilia and systemic symptoms (DRESS): A histopathology based analysis
Sarita Sasidharanpillai, Aparna Govindan, Najeeba Riyaz, Manikoth P Binitha, Kunnummal Muhammed, Anza Khader, Olasseri K Reena Mariyath, Muhammedkutty Simin, Kunnari Subin
January-February 2016, 82(1):28-36
DOI:10.4103/0378-6323.168934  PMID:26728807
Background: The data on the histology of cutaneous lesions of drug reaction with eosinophilia and systemic symptoms (DRESS) is limited. Aims: To study the histopathology of cutaneous lesions of drug reaction with eosinophilia and systemic symptoms (DRESS) and to identify any features with diagnostic or prognostic significance. Methods: All patients admitted to the dermatology ward of government medical college, Kozhikode from January 1, 2014 to December 31, 2014 with probable or definite DRESS as per the RegiSCAR scoring system and who were willing to undergo skin biopsy were included in this prospective study. Results: The study population comprised of nine patients. The consistent histological finding documented was the predominantly lymphocytic dermal inflammatory infiltrate. Four of the five patients whose histology revealed focal interface dermatitis and keratinocyte vacuolation with or without apoptotic keratinocytes, had elevated liver transaminases. Tissue eosinophilia was associated with disease flares. The presence of atypical lymphocytes in peripheral smear and histological evidence of dense dermal inflammatory infiltrate showed an association with hepatic involvement. Limitations: The main limitations of our study were the small sample size and our inability to carry out a detailed immunohistochemistry work-up. Conclusions: In the appropriate setting, varying combinations of epidermal hyperplasia, spongiosis, parakeratosis and individually necrotic keratinocytes in the background of lymphocyte predominant dermal infiltrate (with some atypia) favor a diagnosis of drug reaction with eosinophilia and systemic symptoms. Female sex, the presence of atypical lymphocytes in peripheral smear, dense dermal inflammatory infiltrate, tissue eosinophilia and interface dermatitis with or without keratinocyte necrosis was associated with a poor prognosis.
  - 3,673 259
Prevalence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in genital samples collected over 6 years at a Serbian university hospital
Dusan Skiljevic, Damjan Mirkov, Jelica Vukicevic
January-February 2016, 82(1):37-41
DOI:10.4103/0378-6323.172903  PMID:26728808
Background: Mycoplasma hominis and Ureaplasma urealyticum are implicated in a wide array of infectious diseases in adults and children. Since some species have innate or acquired resistance to certain types of antibiotics, antibiotic susceptibility testing of mycoplasma isolated from the urogenital tract assumes increasing importance. Aims: To evaluate the prevalence and antibiotic susceptibility of M. hominis and U. urealyticum in genital samples collected between 2007 and 2012. Methods: Three hundred and seventy three patients presenting with symptoms of sexually transmitted diseases, infertility or risky sexual behaviour, who had not taken antibiotics in the previous 6 weeks and had ≥10 WBC per high power field on genital smears were studied. Urethral samples were taken in men and endocervical samples in women. The mycoplasma IST-2 kit was used for organism identification and for testing susceptibility to doxycycline, josamycin, ofloxacin, erythromycin, tetracycline, ciprofloxacin, azithromycin, clarithromycin and pristinamycin. Results: U. urealyticum was isolated from 42 patients and M. hominis from 11 patients. From 9.8% of isolates, both organisms were grown. All M. hominis isolates were resistant to tetracycline, clarithromycin and erythromycin while U. urealyticum was highly resistant to clarithromycin (94.6%), tetracycline (86.5%), ciprofloxacin (83.8%) and erythromycin (83.8%). M. hominis was sensitive to doxycycline (83.3%) and ofloxacin (66.7%) while most U. urealyticum strains were sensitive to doxycycline (94.6%). Limitations: Inability of the commercial kit used in the study to detect other potentially pathogenic urogenital mycoplasmas (Ureaplasma parvum, Mycoplasma genitalium). Conclusion: There is significant resistance of U. urealyticum and M. hominis to tetracycline and macrolides. The most active tetracycline for genital mycoplasmas was found to be doxycycline, which continues to be the drug of first choice.
  - 4,298 94
PERSPECTIVE
Melanocyte-keratinocyte transplantation procedure: A few insights
Sanjeev V Mulekar
January-February 2016, 82(1):13-15
DOI:10.4103/0378-6323.172904  PMID:26728804
  - 3,663 285
QUIZ
Solitary asymptomatic nodule on the leg
Ana Almodovar-Real, José Aneiros-Fernandez, Miguel A Diaz-Martinez, Ramón Naranjo-Sintes
January-February 2016, 82(1):109-111
DOI:10.4103/0378-6323.168940  PMID:26728833
  - 1,671 113
RESIDENTS CORNER
Viva questions from the IJDVL
Vishalakshi Viswanath, Resham Vasani
January-February 2016, 82(1):114-119
DOI:10.4103/0378-6323.172911  
  - 6,909 857
RESIDENTS PAGE
Retinoids as chemopreventive agents
Sandeep Kaur
January-February 2016, 82(1):59-64
DOI:10.4103/0378-6323.168942  PMID:26728813
  - 2,980 517
REVIEW ARTICLE
Paradoxical reactions induced by tumor necrosis factor-alpha antagonists: A literature review based on 46 cases
Rodica Olteanu, Alexandra Zota
January-February 2016, 82(1):7-12
DOI:10.4103/0378-6323.172898  PMID:26728803
Anti-tumor necrosis factor (TNFα) agents have acquired a prominent place in the treatment options for inflammatory disorders. Among the side effects of these agents are the so-called paradoxical reactions which have increasingly been reported in recent years. A review of literature was carried out using Medline (PubMed) database from January 2010 to December 2014 to collect all published articles on cases of anti-TNFα-induced psoriasis and psoriatic arthritis. Published articles were identified, reviewed and the relevant data extracted. A total of 22 studies (46 patients) fulfilled the inclusion criteria and were selected for analysis. Of the 46 patients, 45 (97.8%) developed psoriasis and 1 (2.1%) psoriatic arthritis. The mean age of patients was 47 years; three (6.5%) patients had a past history of psoriasis. Infliximab caused cutaneous reactions in the most number, 26 (56.5%) cases. Thirty seven (80.4%). patients developed primary plaque-type psoriasis. Women accounted for 86.9% of patients. There was complete resolution of psoriasis in 12 (26%) patients despite differences in the therapeutic approach. Cessation of the incriminated drug led to resolution of cutaneous lesions in 5 (10.8%), switching to another TNFα antagonist led to resolution in 6 (13%) and one (2.1%) patient improved despite continuation of the drug. As for the lone case of psoriatic arthritis, drug withdrawal did not result in improvement; only switching to another anti-TNFα agent helped. Since our sample was small, it was not adequately powered to draw any firm conclusions. However, in this analysis, we found that paradoxical reactions occurred predominantly in adult women, there were only isolated cases with a personal history of psoriasis, infliximab was responsible for most cases of these reactions and the most prevalent form was plaque-type psoriasis. The decision whether to continue or discontinue the triggering anti-TNFα agent should be individualized as results are highly variable.
  - 3,122 234
THERAPEUTIC GUIDELINES - IADVL
Targeted phototherapy
Venkataram Mysore, BM Shashikumar
January-February 2016, 82(1):1-6
DOI:10.4103/0378-6323.172902  PMID:26728802
Background: Targeted phototherapy is a new form of phototherapy which has many advantages and disadvantages over conventional phototherapy. This article reviews the different technologies and outlines recommendations based on current evidence. Methods: A literature search was performed on targeted phototherapy to collect data. Relevant literature published till March 2014 was obtained from PubMed, EMBASE, and the Cochrane Library. Keywords like “targeted phototherapy”, “excimer laser”, “excimer lamp”, “Nonchromatic ultraviolet light”, “vitiligo”, and “psoriasis”, were used for literature search. All systematic reviews, meta-analysis, national guidelines, randomized controlled trials (RCT), prospective open label studies and retrospective case series in English were reviewed. Results: Three hundred and forty studies were evaluated, 24 of which fulfilled the criteria for inclusion in the guidelines. Conclusions and Recommendations: All forms of targeted phototherapy are useful in vitiligo. Good responses were seen in localized involvement, resistant lesions and in children in whom their use is more accepted and convenient (Level of evidence 2+, Grade of recommendation B). Similarly it is useful in psoriasis, either alone or in combination with drugs, even in resistant forms such as palmoplantar psoriasis. In view of expense and practical application, their use is limited to resistant lesions and localized disease. (Level of evidence 2+, Grade of recommendation B). But in other conditions there is no convincing evidence for its use. (Level of evidence 3+, Grade of recommendation C).
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Online since 15th March '04
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