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   2015| November-December  | Volume 81 | Issue 6  
    Online since October 28, 2015

 
 
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LETTERS TO THE EDITOR - OBSERVATION LETTERS
Valacyclovir-induced urticaria without acyclovir hypersensitivity
Satyendra K Singh, Anand Prabhu, Ajit Kumar
November-December 2015, 81(6):611-612
DOI:10.4103/0378-6323.168346  PMID:26515842
  1 3,248 100
Pityriasis rubra pilaris occurring after vaccination with diphtheria-pertussis-tetanus and oral poliovirus vaccines
Mariem Mohamed, Hichem Belhadjali, Faten Hammedi, Chebil Ben Meriem, Jameleddine Zili
November-December 2015, 81(6):618-620
DOI:10.4103/0378-6323.168326  PMID:26515846
  1 2,350 93
LETTERS TO THE EDITOR - THERAPY LETTERS
Tacrolimus for treatment of toxic epidermal necrolysis
Pavitra M Dogra, Manas Chatterjee, Shekhar Neema
November-December 2015, 81(6):642-644
DOI:10.4103/0378-6323.168328  PMID:26515857
  1 2,243 120
Successful treatment of cutaneous leishmaniasis with nitazoxanide
Amit Kumar Dhawan, Kavita Bisherwal, Vijay Gandhi, Archana Singal, Sonal Sharma
November-December 2015, 81(6):644-646
DOI:10.4103/0378-6323.165541  PMID:26515858
  1 3,174 104
BOOK REVIEW
Handbook of dermatologic drug therapy
AK Bajaj
November-December 2015, 81(6):654-654
  - 1,818 159
BRIEF REPORT
Targeted ultraviolet B phototherapy in vitiligo: A comparison between once-weekly and twice-weekly treatment regimens
Imran Majid, Saher Imran
November-December 2015, 81(6):600-605
DOI:10.4103/0378-6323.168325  PMID:26515839
Background: Targeted ultraviolet B (T-UVB) phototherapy in vitiligo is usually administered twice or thrice a week on non-consecutive days. It is difficult for many patients to adhere to this regimen, forcing them to discontinue treatment. Aim: The study aimed to compare the efficacy of twice-weekly and once-weekly targeted ultraviolet B phototherapy regimens in vitiligo. Methods: Sixty patients with non-segmental vitiligo on the face, neck or trunk were divided into two groups of 30 patients each. The patients in group A received targeted ultraviolet B twice weekly, while those in group B received targeted ultraviolet B once weekly. Repigmentation was monitored and graded as excellent (≥75% repigmentation), good (50−74% repigmentation) and poor (<50% repigmentation). The extent of repigmentation at each body site (primary outcome measure), the number of doses required for initiation of pigmentation, and the cumulative dose of targeted ultraviolet B administered was calculated and compared between both groups. Results: A total of 90 lesions (48 in the twice weeklygroup and 42 in the once weekly group) were treated on the face, neck and trunk. Excellent results were obtained in 62.5% (30/48) of lesions treated twice weekly, and 64.3% (27/42) in lesions treated once weekly. The mean number of doses required for initiation of pigmentation was 4.69 in the twice weekly group, and 4.35 in the once weekly group. The patients in the twice weekly group received a mean cumulative dose of 8.26 J/cm 2, while the once weekly group received 7.69 J/cm 2. No statistically significant differences were observed between the two groups with respect to the outcome, with respect to the total repigmentation, the number of doses till onset of pigmentation, as well as the cumulative dose of targeted UVB. Conclusion: Once-weekly targeted ultraviolet B phototherapy appears to be as efficacious as the twice-weekly regimen in vitiligo.
  - 6,112 231
COMMENTARY
Understanding macular pigmentation of uncertain aetiology
Sujith Prasad Kumarasinghe
November-December 2015, 81(6):581-583
PMID:26515835
  - 2,862 202
E-IJDVL - NET LETTERS
Vesicular lesions in lichen amyloidosis
Resham J Vasani
November-December 2015, 81(6):655-655
DOI:10.4103/0378-6323.165542  PMID:26515863
  - 2,447 87
Self-perceived emotional side effects of systemic corticosteroid therapy in dermatology patients
Shubh Mohan Singh, Tarun Narang, Sunil Dogra, Sanjeev Handa
November-December 2015, 81(6):655-655
DOI:10.4103/0378-6323.168324  PMID:26515864
  - 1,732 92
Pemphigus vegetans associated with Gitelman syndrome
H Akkari, M Belkahla, M Youssef, A Letaief, Y Soua, B Sriha, H Belhadjali, J Zil
November-December 2015, 81(6):655-655
DOI:10.4103/0378-6323.168342  PMID:26515865
  - 2,664 91
Streptococcal vulvovaginitis in adults: Not a rare entity
Veena Chandran, Sadeep Melethil Sadanandan, P Seena, K Sobhanakumari, George Kurien, Vishnu Mohan
November-December 2015, 81(6):655-655
DOI:10.4103/0378-6323.168351  PMID:26515866
  - 2,179 87
Benign penile melanosis: A linear variant
Vijayeeta Jairath, Nidhi Jindal, Manu Sehrawat, VK Jain, Sarabjit Kaur, MM Priyadarshini
November-December 2015, 81(6):655-655
DOI:10.4103/0378-6323.168352  PMID:26515867
  - 24,501 89
Superficial epidermolytic ichthyosis
Anirban Das, Anupam Das, Sabari Bhattacharya, Anupama Ghosh, Kaushik Shome
November-December 2015, 81(6):656-656
DOI:10.4103/0378-6323.158637  PMID:26515868
  - 3,630 115
IMAGES IN CLINICAL PRACTICE
Pseudocyst of the auricle
Sudip Kumar Ghosh, Debabrata Bandyopadhyay
November-December 2015, 81(6):606-607
DOI:10.4103/0378-6323.168355  PMID:26515840
  - 2,034 114
Blepharochalasis with double lip: A case of Ascher syndrome
Vishal Gupta, Sujay Khandpur
November-December 2015, 81(6):651-651
DOI:10.4103/0378-6323.158645  PMID:26515861
  - 2,955 108
LETTERS TO THE EDITOR - CASE LETTERS
Ankyloblepharon–ectodermal dysplasia–clefting syndrome
BG Ramya, Swati Gondane, Surendra Kumar, Sapna Dangi
November-December 2015, 81(6):629-630
DOI:10.4103/0378-6323.168333  PMID:26515851
  - 3,224 91
Systemic T cell lymphoma presenting as cutis verticis gyrata
Anu A George, Leni George, Gauri Mahabal, Mandeep Bindra, Susanne Pulimood
November-December 2015, 81(6):631-633
DOI:10.4103/0378-6323.168339  PMID:26515852
  - 2,242 85
Easy bruising due to giant platelet (possibly MYH9-related/Sebastian) syndrome
Indrashis Podder, Maitrayee Saha, Anupam Das, Ramesh Chandra Gharami
November-December 2015, 81(6):633-635
DOI:10.4103/0378-6323.168354  PMID:26515853
  - 2,276 76
Infantile dermatofibrosarcoma protuberans: An underrecognized diagnosis?
Giulio Gualdi, Laura Pavoni, Paola Monari, Lucia Corasaniti, Pierluigi Pedersini, Maria Pia Bondioni, Paolo Incardona, Daniele Alberti, PierGiacomo Calzavara-Pinton, Ausilia Maria Manganoni
November-December 2015, 81(6):635-637
DOI:10.4103/0378-6323.168347  PMID:26515854
  - 2,837 77
Anti-BP180-type oral mucous membrane pemphigoid reactive to both NC16a and C-terminal domains
Masaki Uchiyama, Yoshihiko Mitsuhashi, Ryoji Tsuboi, Norito Ishii, Taihei Hayakawa, Atsushi Yasukochi, Takashi Hashimoto
November-December 2015, 81(6):637-639
DOI:10.4103/0378-6323.168330  PMID:26515855
  - 1,761 60
LETTERS TO THE EDITOR - OBSERVATION LETTERS
Crusted scabies diagnosed by reflectance confocal microscopy
Pinar Incel Uysal, Mehmet Salih Gurel, Asli Vefa Erdemir
November-December 2015, 81(6):620-622
DOI:10.4103/0378-6323.164221  PMID:26515847
  - 2,789 99
Ochronosis with subtle histological findings
Archana George Vallonthaiel, Aanchal Kakkar, Manoj Kumar Singh, M Ramam
November-December 2015, 81(6):623-624
DOI:10.4103/0378-6323.168349  PMID:26515848
  - 3,278 101
Bullous pemphigoid with malignant melanoma
Leela Rani Parimi, Mingfei Chen, Hong Liu, Furen Zhang
November-December 2015, 81(6):625-626
DOI:10.4103/0378-6323.168353  PMID:26515849
  - 1,968 78
Dowling-Degos disease and malignant melanoma: Association or mere coincidence?
Vishal Gupta, Kanika Sahni, Prakash Khute, Vinod K Sharma, Mohammad Firdaus Ali
November-December 2015, 81(6):627-628
DOI:10.4103/0378-6323.168334  PMID:26515850
  - 2,021 83
Mixed primary infection by herpes simplex virus 1 and 2 in a 5-month-old infant with no evidence of sexual abuse
Vrushali Patwardhan, Preena Bhalla, Kabir Sardana, Sumit Sethi
November-December 2015, 81(6):612-614
DOI:10.4103/0378-6323.168340  PMID:26515843
  - 3,599 94
Phakomatosis pigmentovascularis Type IIb, Sturge– Weber syndrome and cone shaped tongue: An unusual association
Swetalina Pradhan, Satyadarshi Patnaik, Tanmay Padhi, Bibhu Prasad Nayak
November-December 2015, 81(6):614-616
DOI:10.4103/0378-6323.168335  PMID:26515844
  - 2,402 101
Entomophthoromycosis (basidiobolomycosis) presenting with "saxophone" penis and responding to potassium iodide
Pooja Arora, Kabir Sardana, Shuchi Bansal, Vijay K Garg, Seema Rao
November-December 2015, 81(6):616-618
DOI:10.4103/0378-6323.168332  PMID:26515845
  - 2,449 94
LETTERS TO THE EDITOR - STUDY LETTER
Dermoscopy of aggressive basal cell carcinomas
Mirjana Popadic
November-December 2015, 81(6):608-610
DOI:10.4103/0378-6323.168343  PMID:26515841
  - 3,374 93
LETTERS TO THE EDITOR - THERAPY LETTERS
Sulfasalazine and pentoxifylline, a new adjuvant in young pemphigus patients: A pilot study
Devraj Dogra, Naina Kala Dogra, Nishu Gupta, Vipin Gupta
November-December 2015, 81(6):640-642
DOI:10.4103/0378-6323.168341  PMID:26515856
  - 2,499 148
Keratosis follicularis spinulosa decalvans showing excellent response to isotretinoin
Divya Gupta, Rashmi Kumari, Rakesh Kumar Bahunutula, Devinder Mohan Thappa, Pampa Ch Toi, Pradipta Kumar Parida
November-December 2015, 81(6):646-648
DOI:10.4103/0378-6323.168344  PMID:26515859
  - 3,092 118
Permanent treatment of aquagenic syringeal acrokeratoderma with endoscopic thoracic sympathectomy
Engin Sezer, Emel Öztürk Durmaz, Emel Çetin, Sedef Sahin
November-December 2015, 81(6):648-650
DOI:10.4103/0378-6323.168331  PMID:26515860
  - 5,416 73
ORIGINAL ARTICLES
Narrow band ultraviolet-B versus Goeckerman therapy for psoriasis with and without acitretin: A retrospective study
Ercan Çaliskan, Mustafa Tunca, Gürol Açikgöz, Ercan Arca, Aslan Yürekli, Ahmet Akar
November-December 2015, 81(6):584-587
DOI:10.4103/0378-6323.168329  
Background: Narrow band ultraviolet-B (NB-UVB) is now one of the most widely used modalities in the treatment of psoriasis. However, despite its high efficacy, conventional Goeckerman treatment has fallen out of favor in recent years and some institutions are now using NBUVB with coal tar as their regimen. Objective: To evaluate the efficacy of NB-UVB, Goeckerman therapy and the effect of addition of retinoid to the treatment regimen in the treatment of psoriasis,. Patients and Methods: A retrospective analysis of 65 patients who underwent 81 courses of treatment in our department was undertaken. The efficacy of NB-UVB and Goeckerman therapy individually, and in combination with acitretin was assessed. Data were analysed to evaluate the contribution of acitretin to these modalities. Results: PASI-75 responses in the NB-UVB, retinoid + NB-UVB (re-NB), Goeckerman and retinoid + Goeckerman (re-Goeckerman) groups were achieved for 12 of 31 patients (39%), 13 of 21 patients (62%), 15 of 17 patients (88%) and 10 of 12 patients, respectively. The addition of acitretin to both modalities reduced both the number of sessions and the cumulative ultraviolet-B dose delivered. Limitations: This is a retrospective study, the patients were not randomized and the number of patients in the treatment groups were dissimilar. Conclusion: Goeckerman therapy is more effective than NB-UVB phototherapy. Although the addition of acitretin to both NB-UVB and Goeckerman therapy did not contribute to treatment outcomes in terms of PASI-75 responses, it enabled a reduction in UV exposures and enhanced efficacy.
  - 2,018 242
A morphometric and immunohistochemical study of melanocytes in periorbital hyperpigmentation
Dibyajyoti Boruah, V Manu, Ajay Malik, Manas Chatterjee, Biju Vasudevan, V Srinivas
November-December 2015, 81(6):588-593
DOI:10.4103/0378-6323.168327  PMID:26515837
Background: An increase in number of melanocytes in the basal cell layer of the epidermis is an important feature in many disorders of hyperpigmentation. In this study, we attempted an objective evaluation of the linear density of melanocytes and keratinocytes, along with other epidermal characteristics, in periorbital hyperpigmentation using immunohistochemistry and morphometric techniques. Methods: Melanocytes and epidermal parameters were assessed by digital morphometry in 30 newly diagnosed cases of periorbital hyperpigmentation and 14 controls from the post-auricular region. Melanocytes were labelled with the immunohistochemical stains, Melan-A and tyrosinase. We studied the linear keratinocyte density, mean linear melanocyte density, ratio of melanocytes to keratinocytes, the ratio between inner and outer epidermal length, maximum epidermal thickness and minimum epidermal thickness. Results: Melan-A expression of melanocytes showed strong positive correlation (r = 0.883) with the tyrosinase expression. Mean linear melanocyte density was 24/mm (range: 13–30/mm) in cases and 17/mm (13–21/mm) in controls and this difference was statistically significant (P < 0.001). The mean ratio of melanocyte to keratinocyte was 0.22 (0.12–0.29) in cases and 0.16 (0.12–0.21) in controls; again, this difference was statistically significant (P < 0.001). There was a mild negative correlation with linear keratinocyte density (r = −0.302) and the ratio between inner and outer epidermal length (r = −0.456). However, there were no differences in epidermal thicknesses. Limitations: There were fewer control biopsies than optimal, and they were not taken from the uninvolved periorbital region. Conclusion: Mean linear melanocyte density and the ratio of melanocytes to keratinocytes is increased in cases with periorbital hyperpigmentation. It is, therefore, likely that increased melanocyte density may be the key factor in the pathogenesis of periorbital hyperpigmentation.
  - 2,796 186
Differential expression of solute carrier family 11a member 1 and inducible nitric oxide synthase 2 in skin biopsies from leprosy patients
Ana Laura Pereira-Suárez, Anabell Alvarado-Navarro, Juan Gabriel Barrietos-García, Ciro Estrada-Chávez, José Francisco Muńoz-Valle, Mary Fafutis-Morris
November-December 2015, 81(6):594-599
DOI:10.4103/0378-6323.168345  PMID:26515838
Background: Leprosy is a chronic granulomatous infection caused by Mycobacterium leprae, an intracellular parasite that resides within macrophages and cannot be eliminated effectively. Solute carrier family 11a member 1 (Slc11a1) and inducible nitric oxide synthase (iNOS), both expressed in macrophages, play major roles in host defense against several intracellular pathogens. However, the roles of these molecules in natural infection with M. leprae remain unknown. Objective: We aimed to investigate the expression of Slc11a1 and iNOS in macrophages (CD68+ cells) infiltrating skin lesions in leprosy. Methods: Skin biopsies from 48 Mexican patients of leprosy [(33 lepromatous (LL), 15 tuberculoid (TT)] and from 10 healthy controls, were subjected to immunohistochemistry to determine expression of CD68, Slc11a1 and iNOS. Results: We found a high expression of Slc11a1 and iNOS in most lepromatous leprosy samples. In tuberculoid leprosy samples, Slc11a1 expression was moderate or low, and that of iNOS was almost always low. In addition, Slc11a1 and iNOS expression levels were positively associated with bacillary loads in lepromatous leprosy lesions (P = 0.05). Conclusions: These observations suggest that M. leprae infection promotes the expression of Slc11a1 and iNOS in macrophages and that lepromatous leprosy can occur despite this response.
  - 1,216 77
QUIZ
A fleshy protuberant growth on the leg
Premanshu Bhushan, Sarvesh Sunil Thatte, Avninder Singh
November-December 2015, 81(6):652-653
DOI:10.4103/0378-6323.168338  PMID:26515862
  - 2,631 173
RESIDENTS CORNER
Viva questions from the IJDVL
Vishalakshi Viswanath, Resham Vasani
November-December 2015, 81(6):657-662
DOI:10.4103/0378-6323.168414  
  - 5,217 860
REVIEW ARTICLE
Sun-related behaviors among individuals previously diagnosed with non-melanoma skin cancer
Vinayak K Nahar, M Allison Ford, Stephanie K Jacks, Scott P Thielen, Andrea K Johnson, Robert T Brodell, Martha A Bass
November-December 2015, 81(6):568-575
DOI:10.4103/0378-6323.168337  PMID:26515833
Compared to the general population, the risk of developing non-melanoma skin cancer is considerably higher among individuals with a previous history of this condition. Protection from ultraviolet (UV) radiation is the primary evidence-based approach for minimizing this risk. This review was aimed to assess the prevalence of sun-safe behaviors in non-melanoma skin cancer survivors. Searches were conducted in six electronic databases including PubMed, Psyclnfo, CINAHL, EMBASE, ERIC and Science Direct. A narrative approach was adopted to synthesize the data. The findings demonstrated that respondents do not protect themselves optimally from UV radiation exposure. Low levels of perceived skin cancer risk, a lack of knowledge about effective sun protection strategies and the inconvenience associated with sun-safe behaviors appear to explain this finding. A note of caution is required here, as there is a potential for publication bias. Moreover, the results of this study cannot be generalized to all non-melanoma skin cancer patients. Skin cancer survivors must be educated about their increased risk of future skin cancers. Behavioral interventions must be developed to increase the adoption of skin protective behaviors in this high-risk population group.
  - 3,805 164
THERAPEUTIC GUIDELINES - IADVL
Guidelines for bath PUVA, bathing suit PUVA and soak PUVA
Sathish B Pai, Shricharith Shetty
November-December 2015, 81(6):559-567
DOI:10.4103/0378-6323.168336  PMID:26515832
Background: The aim of these guidelines is to encourage dermatologists to use bath psoralen plus ultraviolet A (PUVA), bathing suit PUVA and soak PUVA in the treatment of psoriasis vulgaris and other conditions. Methods: Evidence was collected using searches of the PubMed, MEDLINE and COCHRANE databases using the keywords “bath PUVA,” “soak PUVA,” “bathing suit PUVA” and “turban PUVA.” Only publications in English were reviewed. Results: One hundred and thirty-eight studies were evaluated, 57 of which fulfilled the criteria for inclusion. Conclusions: Both bath PUVA and bathing suit PUVA are very effective and safe treatments for generalized stable plaque psoriasis (strength of recommendation, A). Soak PUVA is very effective in the treatment of both palmoplantar psoriasis and chronic palmoplantar eczema (strength of recommendation, A).
  - 14,117 1,142
VIEWPOINT
Idiopathic eruptive macular pigmentation: A critical review of published literature and suggestions for revision of criteria for diagnosis
Rajiv Sharad Joshi, Shaurya Rohatgi
November-December 2015, 81(6):576-580
DOI:10.4103/0378-6323.168323  PMID:26515834
  - 4,990 281
Online since 15th March '04
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