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  Citation statistics : Table of Contents
   2015| September-October  | Volume 81 | Issue 5  
    Online since August 28, 2015

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Recent advances in topical formulation carriers of antifungal agents
Eman Ahmed Bseiso, Maha Nasr, Omaima Sammour, Nabaweya A Abd El Gawad
September-October 2015, 81(5):457-463
DOI:10.4103/0378-6323.162328  PMID:26261140
Fungal infections are amongst the most commonly encountered diseases affecting the skin. Treatment approaches include both topical and oral antifungal agents. The topical route is generally preferred due to the possible side effects of oral medication. Advances in the field of formulation may soon render outdated conventional products such as creams, ointments and gels. Several carrier systems loaded with antifungal drugs have demonstrated promising results in the treatment of skin fungal infections. Examples of these newer carriers include micelles, lipidic systems such as solid lipid nanoparticles and nanostructured lipid carriers, microemulsions and vesicular systems such as liposomes, niosomes, transfersomes, ethosomes, and penetration enhancer vesicles.
  2 9,252 792
Cetirizine-induced urticaria masquerading as multiple drug intolerance syndrome
Saurabh Singh, Pawan Kumar, Vinod K Sharma
September-October 2015, 81(5):537-539
DOI:10.4103/0378-6323.162338  PMID:26261146
  1 3,413 181
Color atlas and synopsis of pediatric dermatology
AJ Kanwar
September-October 2015, 81(5):545-546
  - 1,525 111
Evaluation of role of Candida in patients with chronic paronychia
Rakesh Kumar Bahunuthula, Devinder Mohan Thappa, Rashmi Kumari, Rakesh Singh, Malathi Munisamy, Subash Chandra Parija
September-October 2015, 81(5):485-490
DOI:10.4103/0378-6323.158635  PMID:26087081
Background: Chronic paronychia, earlier considered to be an infection due to Candida, is currently being considered as a dermatitis of the nail fold. Irritant, allergic and protein contact dermatitis are the suggested major pathogenic mechanisms. Hypersensitivity to Candida is more likely to be the etiology, rather than the infection itself. Aims: To assess the clinico-etiological profiles of patients with chronic paronychia and to determine the role of contact sensitization and hypersensitivity to Candida. Methods: All consecutive patients of chronic paronychia attending the dermatology outpatient department (OPD) were assessed for risk factors, number of nails affected, clinical presentation and presence of fungus, patch tested for contact allergy and prick tested for hypersensitivity to Candida allergen. Results: A total of 80 patients of chronic paronychia were recruited into our study. There was female preponderance (66 patients, 82.5%), with the most common group affected being housewives (47 patients, 58.8%). Frequent washing of hands (64 patients, 80%) was the most common risk factor. Fungal culture was positive in 56.1% (41 patients), the predominant species cultured was Candida albicans (15 patients, 36.5%). Patch testing with Indian standard series was positive in 27.1% patients (19 out of 70 patients tested), with nickel being the most common allergen. Prick test with Candida allergen was positive in 47.6% patients (31 out of 65 patients tested). Limitations: Prick test and patch test provide indirect evidence of hypersensitivity, with inherent limitations. Conclusion: Our study shows that chronic paronychia is probably a form of hand dermatitis associated with prolonged wet work, and that there is a higher incidence of contact sensitization and Candida hypersensitivity in these patients.
  - 5,040 217
Disseminated cutaneous phaeohyphomycosis due to Cladophialophora bantiana
Anza Khader, Betsy Ambooken, Manikoth Payyanadan Binitha, Saji Francis, Ashokan K Kuttiyil, Deepthi Nalini Sureshan
September-October 2015, 81(5):491-494
DOI:10.4103/0378-6323.162333  PMID:26261143
Cladophialophora bantiana is a neurotropic dematiaceous fungus which only rarely affects the skin. We report a case of disseminated cutaneous phaeohyphomycosis caused by Cladophialophora bantiana in an immunocompromised female who presented with multiple pyogenic granuloma-like nodules, dermatophytosis-like plaque, and subcutaneous cysts on the upper and lower extremities without systemic involvement. Biopsy revealed black yeasts resembling sclerotic bodies and culture yielded irregular, velvety, grey colonies with black reverse. Excisionof the nodules and treatment with oral itraconazole 100 mg twice daily resulted in complete clinical resolution within two months, following which itraconazole was administered for another 4 months.
  - 2,712 145
Cutaneous annular lesions as the first sign of transformation of follicular lymphoma into diffuse large B-cell lymphoma
Irene Palacios-Álvarez, Concepción Román-Curto, Alejandro Martín García-Sancho, Ángel Santos-Briz, Juan Carlos Santos-Durán, Emilia Fernández-López
September-October 2015, 81(5):495-497
DOI:10.4103/0378-6323.158660  PMID:26087101
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma with diverse clinical, pathological and genetic features. An 80-year-old woman was diagnosed with a stage IV-X-A (Ann Arbor staging system) low grade systemic follicular lymphoma (FL). Four months after the diagnosis, she developed asymptomatic, indurated, annular erythematous plaques with centrifugal growth on the abdomen, arms and neck. The skin biopsy revealed a dermal infiltration compatible with diffuse large B-cell lymphoma. Light chain restriction by flow cytometry was demonstrated. The variable, diverse and joining genes of immunoglobulin G heavy chains were sequenced and cloned, and showed the same pattern for both the initial follicular lymphoma and the skin infiltration. Translocation t (14;18) was present in both samples. Based on these findings, a diagnosis of transformation of follicular lymphoma into diffuse large B cell lymphoma was made. Although other hematological disorders such as primary cutaneous diffuse large B cell lymphoma, mycosis fungoides and the cutaneous infiltration of chronic juvenile myeloid leukemia can present as annular lesions, we were unable to find any previous reports of these as a manifestation of cutaneous infiltration by systemic non-Hodgkin lymphoma.
  - 3,524 129
Pyoderma gangrenosum in successive pregnancies
Chintagunta Sudha Rani, Arakkal Geeta Kiran, Damarla Sudha Vani, Enubothula Nirmala Devi
September-October 2015, 81(5):548-548
DOI:10.4103/0378-6323.158638  PMID:26087084
  - 2,464 100
Chemokine receptors CCR5 and CCR2 genes in HIV positive, HIV exposed seronegative and in HIV unexposed individuals: A study from Mumbai
Deepali V Chaudhari, Shilpa C Kerkar, Vijay Chavan, Preeti R Mehta, Jayanti Mania-Pramanik
September-October 2015, 81(5):548-548
DOI:10.4103/0378-6323.158642  PMID:26087087
  - 2,500 92
Atypical clinical presentation of molluscum contagiosum in an epidermal cyst
Han Mi Jung, Won Joon Choi, Ki Min Sohn, Jung Eun Kim, Hoon Kang
September-October 2015, 81(5):548-548
DOI:10.4103/0378-6323.158648  PMID:26087091
  - 3,066 94
Persistent pruritic rash: A rare manifestation and possible poor prognostic sign in adult onset Still's disease
Najeeba Riyaz, Neeraj Manikath, Sarita Sasidharanpillai, Aparna Govindan, Hena Davul, Mengassery R Rini
September-October 2015, 81(5):548-548
DOI:10.4103/0378-6323.158659  PMID:26087100
  - 3,066 96
Lipoid proteinosis
Angoori Gnaneshwar Rao, Divya Koppada
September-October 2015, 81(5):549-549
DOI:10.4103/0378-6323.157449  PMID:25994884
  - 5,225 221
Infantile hemangioma associated with PHACES syndrome showing a dramatic response to oral propranolol
Bhukya Amar Singh, Yaramati Sri Harsha, Bellum Siva Nagi Reddy
September-October 2015, 81(5):549-549
DOI:10.4103/0378-6323.158641  PMID:26087086
  - 3,338 153
Efficacy and safety of 0.1% kinetin cream in the treatment of photoaging skin
Rungsima Wanitphakdeedecha, Walailak Meeprathom, Woraphong Manuskiatti
September-October 2015, 81(5):547-547
DOI:10.4103/0378-6323.157446  PMID:25994881
Background: Kinetin is a plant-derived compound, which is reported to possess antiaging properties. It has been used in a topical cream to manage facial photo-damage and aging. Although studies elsewhere have shown its benefits, not many studies of the effects of kinetin in Asian skin are available. Objectives: To assess the efficacy and tolerability of 0.1% kinetin cream in the treatment of facial photo-aging. Methods: The study was designed to be open-label and single-blinded, without a control group. One hundred Thai female and male subjects with mild, moderate or severe facial photo-damage were enrolled. They were asked to apply 0.1% kinetin cream twice daily for 12 weeks and follow up at 4, 8, and 12 weeks. Subjective patient self-assessment and physician assessment of facial skin photo-damage were accompanied by digital photographic analysis using the VISIA® (Canfield Scientific Inc, Fairfield, NJ) imaging system. Results: At baseline, most patients reported moderate skin changes related to photo-damage, skin texture, skin color and wrinkles. After 12 weeks, physician and patient assessments showed slight but statistically significant improvements in overall skin condition, skin texture, color, and wrinkles. Findings were similar with the digital photographic system analysis, especially in relation to skin color. Facial ultraviolet spots and redness also showed statistically significant improvements after 12 weeks. The treatment was generally well tolerated. Limitations: The study was designed to be pragmatic and hence no randomization was carried out; there were also no intrapatient or interpatient control observations, and no comparison arm. Conclusion: Kinetin (0.1%) cream was found to slightly improve cutaneous facial photo-damage after 12 weeks of use in a group of Thai patients.
  - 4,601 158
Cutaneous adverse events of epidermal growth factor receptor inhibitors: A retrospective review of 99 cases
Kumutnart Chanprapaph, Padcha Pongcharoen, Vasanop Vachiramon
September-October 2015, 81(5):547-547
DOI:10.4103/0378-6323.157448  PMID:25994883
Background: Previous reports regarding the cutaneous adverse events of epidermal growth factor receptor inhibitors are mostly limited to small case reports and case series, mainly involving Caucasian patients. Aims: We describe the trends in the clinical presentation of Asian patients who had cutaneous adverse events induced by epidermal growth factor receptor inhibitors and to explore the relationship between skin adverse events and tumor response. Methods: From 2006 to 2010, medical records of Thai patients with non-small cell lung cancer receiving epidermal growth factor receptor inhibitors were retrieved and analyzed. Results: In all, 99 patients were reviewed and analyzed. Erlotinib and gefitinib were commenced in 75 (75.8%) and 24 (24.2%) patients, respectively. Cutaneous adverse events occurred in 43 (57.3%) patients receiving erlotinib and in 15 (62.5%) patients receiving gefitinib. The most common adverse event was xerosis (52.5%). Less common adverse events included papulo-pustular eruption (27.3%), erythematous maculopapular rash (11.1%), mucositis (6.7%), paronychia (5.1%), and trichomegaly (2%). Elderly patients had a higher occurrence of xerosis. The presence of cutaneous adverse events was significantly higher in subjects who had a tumor response. Limitations: The limitations of study include its retrospective nature, and the initial screening of cutaneous adverse events was done by non-dermatologists. Conclusions: Cutaneous adverse events due to epidermal growth factor receptor inhibitors are not uncommon in the Asian population. We found a positive correlation between the occurrences of cutaneou adverse events and tumor response supporting the view that they are surrogate markers for therapeutic response.
  - 4,730 167
Making the transition from thesis to published paper: A supervisor's note to her student
Navjeevan Singh
September-October 2015, 81(5):447-450
DOI:10.4103/0378-6323.163694  PMID:26323678
  - 4,187 388
IADVL Invites Application for Editor IJDVL (2017-19)

September-October 2015, 81(5):556-556
  - 1,229 56
Constricting band following incomplete condom removal
Joginder Kumar, V Ramesh
September-October 2015, 81(5):542-542
DOI:10.4103/0378-6323.157452  PMID:25994887
  - 2,459 107
Extensive facial and vulval syringomas in a young woman
Tarang Goyal, Anupam Varshney, Neha Malik
September-October 2015, 81(5):498-498
DOI:10.4103/0378-6323.157453  PMID:25994888
  - 4,103 155
Fingertip eczema to pooja flowers: Allergic contact dermatitis to Tabernaemontana divaricata and Tecoma stans
Chembolli Lakshmi
September-October 2015, 81(5):514-516
DOI:10.4103/0378-6323.162337  PMID:26261145
  - 2,602 107
Tattoo inoculation lupus vulgaris in two brothers
Amit Kumar Dhawan, Deepika Pandhi, Neelam Wadhwa, Archana Singal
September-October 2015, 81(5):516-518
DOI:10.4103/0378-6323.158658  PMID:26087099
  - 3,422 126
Unilateral cutaneous vasculitis: An uncommon presentation and a possible explanation
Burak Tekin, Andac Salman, Serhan Tuglular, Derya Guler, Gulsen Ozen, Haner Direskeneli, Fatma Gulcicek Ayranci, Leyla Cinel, Tulin Ergun
September-October 2015, 81(5):518-519
DOI:10.4103/0378-6323.162319  PMID:26261133
  - 5,086 101
Dermato-neuro syndrome associated with scleromyxedema
Bedriye Karaman, Ayse Guler, Ilgen Ertam, Nese Celebisoy
September-October 2015, 81(5):519-521
DOI:10.4103/0378-6323.162344  PMID:26261151
  - 2,629 79
Black grain eumycetoma of the breast misdiagnosed as fibroadenoma
Sunil K Kothiwala, Saroj Purohit, Mayuri Meena, Arpita Jindal
September-October 2015, 81(5):521-523
DOI:10.4103/0378-6323.162329  PMID:26261141
  - 2,117 87
Scrotal elephantiasis secondary to recalcitrant hidradenitis suppurativa
Pedro T de Vasconcelos, João Décio-Ferreira, Paulo L Filipe
September-October 2015, 81(5):524-525
DOI:10.4103/0378-6323.158656  PMID:26087097
  - 2,678 84
Pemphigus foliaceus occurring with adenocarcinoma of prostate
Meenakshi Wadhokar, Yugal K Sharma, Kirti Deo, Archana Buch, Aayush Gupta
September-October 2015, 81(5):525-526
DOI:10.4103/0378-6323.162332  PMID:26261142
  - 2,025 101
Tuberous sclerosis presenting with late onset seizures and scrotal angiofibromas
Rahul Ray, Kirti Jangid, Biju Vasudevan, Jandhyala Sridhar, Aarti Trehan, Rohan Kodgule
September-October 2015, 81(5):527-529
DOI:10.4103/0378-6323.162324  PMID:26261138
  - 1,996 84
Papular elastorrhexis
Ruzeng Xue, Liyan Yuan, Huaiqiu Huang
September-October 2015, 81(5):529-531
DOI:10.4103/0378-6323.162339  PMID:26261147
  - 3,294 102
Trichilemmal carcinoma in a young adult
Noo Ri Lee, Seung Joon Oh, Mi Ryung Roh
September-October 2015, 81(5):531-533
DOI:10.4103/0378-6323.158644  PMID:26087088
  - 3,068 81
Melanoma arising from the epidermis overlying an acquired intradermal nevus on the forehead
Noriaki Nakai, Norito Katoh
September-October 2015, 81(5):533-535
DOI:10.4103/0378-6323.158653  PMID:26087094
  - 3,035 72
Peripheral T-cell lymphoma, not otherwise specified with prominent cutaneous involvement
Ben Jacob Friedman, Chauncey A McHargue, Michael D Nauss
September-October 2015, 81(5):535-537
DOI:10.4103/0378-6323.162315  PMID:26261131
  - 2,033 80
Pseudo-lipomatosis cutis: A singular dermal artifact
Rajiv Joshi
September-October 2015, 81(5):504-505
DOI:10.4103/0378-6323.162336  PMID:26261144
  - 2,337 78
Palatal ecchymosis associated with irrumation
Kavitha Muthu, Sathya Kannan, Senthilkumar Muthusamy, Preena Sidhu
September-October 2015, 81(5):505-507
DOI:10.4103/0378-6323.162343  PMID:26261150
  - 14,305 90
Matchbox sign: Look before you label!
Premanshu Bhushan, Sarvesh S Thatte, Kashish Kalra
September-October 2015, 81(5):507-509
DOI:10.4103/0378-6323.162321  PMID:26261135
  - 2,677 252
Pemphigus vegetans localized to unusual sites
Geeti Khullar, Dipankar De, Tarun Narang, Uma Nahar Saikia, Sanjeev Handa
September-October 2015, 81(5):509-511
DOI:10.4103/0378-6323.162317  PMID:26261132
  - 3,258 126
Extrafacial rosacea with predominant scalp involvement
Laura Miguel-Gomez, Pablo Fonda-Pascual, Sergio Vano-Galvan, Rosario Carrillo-Gijon, Ernesto Muñoz-Zato
September-October 2015, 81(5):511-513
DOI:10.4103/0378-6323.162340  PMID:26261148
  - 4,260 96
Failure to detect Mycobacterium lepromatosis as a cause of leprosy in 85 Chinesepatients
Yan Zhang, Yong hu Sun, Chuan Wang, Dan Liu, Mingfei Chen, Xi'an Fu, Guizhi Zhou, Hong Liu, Furen Zhang
September-October 2015, 81(5):499-500
DOI:10.4103/0378-6323.162326  PMID:26261139
  - 2,260 95
Clinical and epidemiological profile of sexually transmitted infections in a tertiary care centre in Kerala: A 1-year observational study
Puravoor Jayasree, Manikoth P Binitha, Riyaz Najeeba, George Biju
September-October 2015, 81(5):500-503
DOI:10.4103/0378-6323.158646  PMID:26087090
  - 2,710 155
Topical mTOR (mechanistic target of rapamycin) inhibitor therapy in facial angiofibroma
Debopam Samanta
September-October 2015, 81(5):540-541
DOI:10.4103/0378-6323.163800  PMID:26323682
  - 2,873 135
Comprehensive lipid tetrad index, atherogenic index and lipid peroxidation: Surrogate markers for increased cardiovascular risk in psoriasis
S Sunitha, Medha Rajappa, Devinder Mohan Thappa, Laxmisha Chandrashekar, Malathi Munisamy, G Revathy, M Priyadarssini
September-October 2015, 81(5):464-471
DOI:10.4103/0378-6323.163734  PMID:26323680
Background and Objectives: Recently, the concept of "psoriatic march" has come to the fore, in which chronic cutaneous inflammation in psoriasis leads to systemic inflammation which, in conjunction with increased oxidative stress, triggers a cascade of events resulting in increased cardiovascular risk in patients with severe psoriasis. We, therefore, decided to study the levels of some biochemical cardiovascular risk markers: lipid peroxidation (malondialdehyde), lipoprotein (a), lipid indices and atherogenic index, in patients with psoriasis and their association with disease severity. Methods: Fortyfive patients with psoriasis and 45 age and gender-matched healthy controls were included in this cross-sectional study. Disease severity was assessed by the Psoriasis Area Severity Index (PASI). Serum malondialdehyde, lipoprotein (a) and fasting lipid profile were estimated in all study subjects. Lipoprotein ratios were computed using standard formulae. Atherogenic index was calculated as ratio of lipoprotein (a)/high-density lipoprotein. Results: In psoriasis, we observed significantly higher levels of malondialdehyde, total cholesterol, low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, lipoprotein (a), lipid ratios, atherogenic index and comprehensive lipid tetrad index, compared to controls. These levels were directly proportional to disease severity. Serum levels of malondialdehyde correlated positively with serum lipoprotein (a), comprehensive lipid tetrad index and atherogenic index. Limitations: Different morphological types of psoriasis were not included and follow-up post-therapy was not done. A larger sample size would have validated the results further. Conclusion: Our results indicate that psoriasis, especially the severe variants, are associated with increased oxidative stress and dyslipidemia, which correlate positively with atherogenic index and hence, an increased cardiovascular risk.
  - 3,578 221
Controlled trial comparing the efficacy of 88% phenol versus 10% sodium hydroxide for chemical matricectomy in the management of ingrown toenail
Chander Grover, Ananta Khurana, Sambit Nath Bhattacharya, Arun Sharma
September-October 2015, 81(5):472-477
DOI:10.4103/0378-6323.163787  PMID:26323681
Background: Partial nail avulsion with lateral chemical matricectomy is the treatment of choice for ingrown toenails. Phenol (88%) is the most widely used chemical agent but prolonged postoperative drainage and collateral damage are common. Sodiumhydroxide (NaOH) 10% has fewer side-effects. Methods: Adult, consenting patients with ingrown toenails were alternately allocated into two treatment groups in the order of their joining the study, to receive either 88% phenol (Group 1, n = 26) or 10% NaOH (Group 0, n = 23) chemical matricectomy. The patients as well as the statistician were blinded to the agent being used. Post-procedure follow-up evaluated median duration of pain, discharge, and healing along with recurrence, if any, in both the groups. The group wise data was statistically analyzed. Results: Both the groups responded well to treatment with the median duration of postoperative pain being 7.92 days in Group 0 and 16.25 days in Group 1 (P < 0.202). Postoperative discharge continued for a median period of 15.42 days (Group 0) and 18.13 days (Group 1) (P < 0.203). The tissue condition normalized in 7.50 days (Group 0) and 15.63 days (Group 1) (P < 0.007). Limitations: Limited postsurgical follow up of 6 months is a limitation of the study. Conclusion: Chemical matricectomy using NaOH is as efficacious as phenolisation, with the advantage of faster tissue normalization.
  - 6,120 263
Role of dental restoration materials in oral mucosal lichenoid lesions
Rajneesh Sharma, Sanjeev Handa, Dipankar De, Bishan Dass Radotra, Vidya Rattan
September-October 2015, 81(5):478-484
DOI:10.4103/0378-6323.162341  PMID:26261149
Background: Dental restorative materials containing silver-mercury compounds have been known to induce oral lichenoid lesions. Objectives: To determine the frequency of contact allergy to dental restoration materials in patients with oral lichenoid lesions and to study the effect of removal of the materials on the lesions. Results: Forty-five patients were recruited in three groups of 15 each: Group A (lesions in close contact with dental materials), Group B (lesions extending 1 cm beyond the area of contact) and Group C (no topographic relationship). Thirty controls were recruited in two groups of 15 individuals each: Group D (oral lichenoid lesions but no dental material) and Group E (dental material but no oral lichenoid lesions). Patch tests were positive in 20 (44.5%) patients. Mercury was the most common allergen to elicit a positive reaction in eight patients, followed by nickel (7), palladium (5), potassium dichromate (3), balsam of Peru, gold sodium thiosulphate 2 and tinuvin (2) and eugenol (1), cobalt chloride (1) and carvone (1). Seven patients elicited positive response to more than one allergen. In 13 of 20 patients who consented to removal of the dental material, complete healing was observed in 6 (30%), marked improvement in 7 (35%) and no improvement in 7 (35%) patients. Relief of symptoms was usually observed 3 months after removal. Limitations: Limited number of study subjects and short follow up after removal/replacement of dental restoration materials are the main limitations of this study. Conclusion: Contact allergy to amalgam is an important etiologic factor in oral lichenoid lesions and removal of restorative material should be offered to patients who have lesions in close proximity to the dental material.
  - 4,387 240
Purplish plaques on the leg of a 12-year-old boy
Rajesh Kumar Mandal, Sudip Kumar Ghosh, Abhijit Dutta
September-October 2015, 81(5):543-544
DOI:10.4103/0378-6323.163806  PMID:26323683
  - 2,065 158
Viva questions from the IJDVL
Vishalakshi Viswanath, Resham Vasani
September-October 2015, 81(5):550-555
DOI:10.4103/0378-6323.163808  PMID:26323684
  - 5,901 912
Therapeutic potential of biosimilars in dermatology
Vishal Gupta, Binod K Khaitan
September-October 2015, 81(5):451-456
DOI:10.4103/0378-6323.163706  PMID:26323679
The introduction of biologic therapy has revolutionized the treatment of many chronic diseases, including several dermatological disorders. Biological agents promise to satisfy medical needs previously unmet by conventional medicines. Unfortunately, these agents are expensive and out of reach for the majority of patients who need them. Biosimilars are copies of the innovator biological agents and represent an important advance in the field of biological therapeutics. Although they are similar to the original biologic, differences in terms of structure, efficacy, safety and immunogenicity remain a concern. Thus, biosimilars cannot be regarded as bio-generics. Awareness of the key differences between a biosimilar and its reference biological agent is essential for optimal treatment and safety of patients. The increasing availability of biosimilars provides patients and doctors with less expensive alternatives and increases the accessibility of biologic therapy to needy patients. In this review, we discuss the concept of biosimilars, the need for appropriate regulatory pathways and their current status in dermatology.
  - 8,065 1,314
Online since 15th March '04
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