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   2014| March-April  | Volume 80 | Issue 2  
    Online since March 26, 2014

 
 
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LETTERS TO THE EDITOR
Central retinal artery occlusion and cerebral inrfaction following forehead injection with a corticosteroid suspension for vitiligo
Ou-gen Liu, Li Chunming, Wang Juanjuan, Xiong Xiaoyan
March-April 2014, 80(2):177-179
DOI:10.4103/0378-6323.129416  PMID:24685869
  3 2,012 68
Disseminated molluscum contagiosum in a patient on methotrexate therapy for psoriasis
Shivani Bansal, Vineet Relhan, Esha Roy, Vijay Kumar Garg, Nita Khurana
March-April 2014, 80(2):179-180
DOI:10.4103/0378-6323.129418  PMID:24685870
  2 2,382 116
Interstitial granulomatous drug reaction due to febuxostat
Laura Atzori, Luca Pilloni, Anna Luisa Pinna
March-April 2014, 80(2):182-184
DOI:10.4103/0378-6323.129420  PMID:24685872
  2 2,772 77
NET LETTERS
Clinico-mycological study of dermatophytes in a tertiary care centre in northwest India
US Agarwal, Jitendra Saran, Puneet Agarwal
March-April 2014, 80(2):194-194
DOI:10.4103/0378-6323.129434  PMID:24685877
  2 2,353 338
ORIGINAL ARTICLES
Extramammary Paget's disease: Analysis of 17 Chinese cases
Yuqing Qi, Jianzhong Hu, Chenwei Sun, Junyan Zhang, Quanzhong Liu
March-April 2014, 80(2):129-133
DOI:10.4103/0378-6323.129385  PMID:24685848
Background/Objective: Extramammary Paget's Disease (EMPD) seems to be more common in Caucasians than Chinese. We report the clinical manifestations, management, and prognostic characteristics in 17 Chinese patients. Methods: Medical records and biopsies of 17 patients who had been treated at a large university hospital in China between March 2005 and January 2012 were reviewed. Results: Of the 17 patients, 14 were men. They had lesions on the scrotum and the penis. Of the three women, two had vulvar and one had inguinal lesions. All patients underwent Mohs micrographic surgery (MMS). Three men had metastasis to the inguinal lymph nodes and underwent an extensive local excision with inguinal lymphadenectomy. Eight patients who had positive excision margins received additional radiation therapy. The mean follow-up duration was 54 months (4-85 months). One patient had two recurrences. Three had metastasis to the inguinal lymph node. One had metastasis to the bone and concomitant prostate cancer. Two patients died of the disease. Conclusion: A striking difference in presentation of EMPD in Chinese compared with Caucasians is the male predominance and location on the penis and scrotum. Mohs micrographic surgery followed by radiotherapy is an effective treatment. Long-term follow-up suggests that the disease has a good prognosis when it does not metastasise.
  2 3,668 124
CASE REPORTS
Tumor of follicular infundibulum: An unsuspected cause of macular hypopigmentation
Asha Kubba, Meenakshi Batrani, Atul Taneja, Vivek Jain
March-April 2014, 80(2):141-144
DOI:10.4103/0378-6323.129391  PMID:24685851
We present three cases of a rare eruptive variant of tumor of follicular infundibulum. Two patients presented with hypopigmented macules. The clinical differential diagnoses considered in these two cases were vitiligo, lichen sclerosus et atrophicus, and idiopathic guttate hypomelanosis. In the third case, the lesions were hypopigmented flat topped maculo-papules diagnosed clinically as verruca plana. In all three cases, the histopathological features of plate like growth of pale keratinocytes connected to the epidermis and peritumoral condensation of elastic fibers were diagnostic. Although no satisfactory treatment is available, the exclusion of other clinical differential diagnosis particularly vitiligo with its psychosocial implications underscores the importance of skin biopsy.
  1 3,399 121
LETTERS TO THE EDITOR
Lindane toxicity following accidental oral ingestion
Sujatha Ramabhatta, GR Sunilkumar, C Somashekhar
March-April 2014, 80(2):181-182
DOI:10.4103/0378-6323.129419  PMID:24685871
  1 9,980 94
Adult variant of self-healing papular mucinosis in a patient treated with interferon α2a
Daniel González Fernández, Blanca Vivanco Allende, Narciso Pérez Oliva
March-April 2014, 80(2):184-186
DOI:10.4103/0378-6323.129421  PMID:24685873
  1 1,777 56
Severe eosinophilia during anti-tumor necrosis factor-alpha therapy for psoriatic arthritis
Giacomo Maria Guidelli, Sara Tenti, Antonella Fioravanti
March-April 2014, 80(2):187-189
DOI:10.4103/0378-6323.129422  PMID:24685874
  1 2,778 66
Epithelioid sarcoma of the extremities
Fatma Akpinar, Emine Dervis, Cuyan Demirkesen, Ali Cem Akpinar, Selma Sonmez Ergun
March-April 2014, 80(2):168-170
DOI:10.4103/0378-6323.129409  PMID:24685864
  1 1,708 58
Mondor's disease
Saikat Bhattacharjee, Preema Sinha, Raju Augustine George, Mihir Gupta
March-April 2014, 80(2):173-175
DOI:10.4103/0378-6323.129413  PMID:24685867
  1 1,991 91
NET LETTERS
Bullous pemphigoid after femur fracture surgery: A mere coincidence?
Rong Zeng, Hao Chen, Yiqun Jiang, Min Li
March-April 2014, 80(2):195-195
DOI:10.4103/0378-6323.129438  PMID:24685881
  1 2,003 57
RESIDENT’S PAGE
Flagellate dermatoses
Premanshu Bhushan, Prateek Manjul, Vinisha Baliyan
March-April 2014, 80(2):149-152
DOI:10.4103/0378-6323.129397  PMID:24685854
  1 9,560 880
REVIEW ARTICLE
Understanding itch: An update on mediators and mechanisms of pruritus
Iffat Hassan, Mir Laieq Ishtiyaq Haji
March-April 2014, 80(2):106-114
DOI:10.4103/0378-6323.129377  PMID:24685845
Pruritus is the most common symptom secondary to skin diseases. Advances in the fields of neurobiology, immunology and physiology have made it possible for us to understand and unravel the deeper pathophysiological basis of pruritus. This review aims to update our current understanding of the mechanisms and mediators of pruritus. Special attention is paid to endogenous itch mediators particularly newly identified ones like endovanilloids, opioids, neurotrophins, cannabinoids, proteases and cytokines. Various theories explaining the peripheral encoding of itch are reviewed. Multiple neural pathways including the central itch pathways as well as supraspinal processing of itch and brain areas involved in pruritus are highlighted. Apart from peripheral itch mediators, spinal neural receptors are also involved in control of itch and should form part of the development of a novel antipruritic strategy. Further studies are required to fill the lacunae in our current understanding of the pathophysiology of pruritus.
  1 13,108 1,152
BOOK REVIEW
Pigmentary disorders: A comprehensive compendium
Venkataram Mysore
March-April 2014, 80(2):196-196
  - 1,506 190
CASE REPORTS
Extensive disseminated cysticercosis
Sujay Khandpur, Sunil Kumar Kothiwala, Binamra Basnet, Rattan Nangia, HA Venkatesh, Raju Sharma
March-April 2014, 80(2):137-140
DOI:10.4103/0378-6323.129389  PMID:24685850
Cysticercosis, especially neurocysticercosis, is a major public health problem in India. We report an unusual case of disseminated cysticercosis with extensive infiltration of the skin, central nervous system, skeletal muscles, eye, lung, and heart. A patient with extensive cutaneous cysticercosis must be thoroughly investigated for widespread internal organ involvement.
  - 3,949 172
Old world leishmaniasis presenting as a nasal mass
Mahdi Bakhshaee, Shahaboddin Shabani, Mehdi Farzadnia, Seyed Aliakbar Shamsian, Pouran Layegh
March-April 2014, 80(2):145-147
DOI:10.4103/0378-6323.129393  PMID:24685852
Mucosal leishmaniasis is a major problem in Latin America but has been rarely noticed in our region. Although there have been a few reports of mucosal involvement especially in the oral cavity from Southwest Iran, yet none have been presented from the Northeast where Leishmania tropica is the major concern. We report a patient with endonasal leishmaniasis due to L. tropica, an extremely rare entity in immunocompetent patients in our region. He presented with a mass in the left nasal vestibule causing a sense of obstruction on the same side, accompanied by occasional rhinorrhea and mild epistaxis. This case exemplifies the need for considering leishmaniasis as a differential diagnosis for nasal obstruction in this endemic area.
  - 1,866 102
EDITORIAL
Streamlining advertisements: Editorial perspective
Uday Khopkar
March-April 2014, 80(2):103-103
DOI:10.4103/0378-6323.129373  PMID:24685843
  - 1,170 93
IMAGES IN CLINICAL PRACTICE
Mucosal carotenoderma
Feroze Kaliyadan
March-April 2014, 80(2):148-148
DOI:10.4103/0378-6323.129396  PMID:24685853
  - 1,348 105
LETTERS TO THE EDITOR
Polycystic ovarian disease: Still an enigma!
Sidharth Sonthalia, Jyotirmaya Bharti
March-April 2014, 80(2):153-154
DOI:10.4103/0378-6323.129398  PMID:24685855
  - 1,696 174
Polycystic ovarian syndrome: A review
Nina Madnani, Kaleem Khan, Phulrenu Chauhan, Parmar
March-April 2014, 80(2):154-155
DOI:10.4103/0378-6323.129399  PMID:24685856
  - 2,117 229
Delleman syndrome or Haberland syndrome?
Shivcharan Lal Chandravanshi, Sujata Lakhtakia
March-April 2014, 80(2):155-156
DOI:10.4103/0378-6323.129400  PMID:24685857
  - 1,462 98
Multibacillary leprosy: Follow up observations on 19 patients treated with 12 monthly doses of rifampicin, ofloxacin and minocycline therapy in Agra
Anil Kumar, Bhavneswar Kumar Girdhar
March-April 2014, 80(2):156-159
DOI:10.4103/0378-6323.129401  PMID:24685858
  - 1,681 108
Occupational contact dermatitis among construction workers: Results of a pilot study
Vikas Sharma, Vikram K Mahajan, Karaninder S Mehta, Pushpinder S Chauhan
March-April 2014, 80(2):159-161
DOI:10.4103/0378-6323.129402  PMID:24685859
  - 2,967 168
Syphilis among sexually transmitted infections clinic attendees in a tertiary care institution: A retrospective data analysis
Sarita Sasidharanpillai, Valiaveetil Bindu, Najeeba Riyaz, Pentam V Beegum Sherjeena, Saleem Rahima, Nirmal Chandrasekhar
March-April 2014, 80(2):161-162
DOI:10.4103/0378-6323.129403  PMID:24685860
  - 1,935 138
Piebaldism with non-intertriginous freckles: What does it mean?
Nilendu Sarma, Sayantani Chakraborty, Dulal Chandra Bhanja, Sneha Ranjan Bhattachraya
March-April 2014, 80(2):163-165
DOI:10.4103/0378-6323.129404  PMID:24685861
  - 2,556 94
Scrub typhus in a child: Looking behind the ear and beyond
Chandrasekaran Venkatesh, Russelian Arulraj, Palanisamy Soundararajan, Sadagopan Srinivasan
March-April 2014, 80(2):165-166
DOI:10.4103/0378-6323.129406  PMID:24685862
  - 1,467 121
Dermatomyositis and nasopharyngeal carcinoma in an Indian patient
Vishal Gupta, Divya Seshadri, Maneesh Kumar Vijay, Puja Sahai, Somesh Gupta
March-April 2014, 80(2):167-168
DOI:10.4103/0378-6323.129408  PMID:24685863
  - 1,391 90
Treatment of multifocal epithelial hyperplasia with imiquimod
Behrooz Barikbin, Zohreh Tehranchinia, Nikoo Mozafari
March-April 2014, 80(2):175-177
DOI:10.4103/0378-6323.129415  PMID:24685868
  - 4,591 93
Periocular granuloma annulare in a child
Sahana M Srinivas, Moupia Goswami, Madhavi Naik
March-April 2014, 80(2):171-172
DOI:10.4103/0378-6323.129410  PMID:24685865
  - 1,959 98
Distinctive manifestations of cutaneous intraneural perineurioma of fingers, compared with typical intraneural perineurioma
Szu-Ying Chin, Yu-Chien Kao, Chia-Fen Yang, Woan-Ruoh Lee
March-April 2014, 80(2):172-173
DOI:10.4103/0378-6323.129412  PMID:24685866
  - 1,323 62
Unilateral Blaschkoid Darier's disease over the forehead
Ashok Krishnarao Ghorpade
March-April 2014, 80(2):189-190
DOI:10.4103/0378-6323.129423  PMID:24685875
  - 1,499 90
NET LETTERS
Successful treatment of multiple facial basal cell carcinomas with imiquimod in a patient with chronic renal failure
Sedef Bayata, Aylin Türel Ermertcan, Gülsüm Gençoglan, Görkem Eskiizmir, Peyker Temiz
March-April 2014, 80(2):195-195
DOI:10.4103/0378-6323.129439  PMID:24685882
  - 1,209 72
Retrospective analysis of fixed drug eruptions among patients attending a tertiary care center in Southern India
Varadraj Vasant Pai, Naveen Narayanshetty Kikkeri, SB Athanikar, Pankaj Shukla, Prasana Bhandari, Vijetha Rai
March-April 2014, 80(2):194-194
DOI:10.4103/0378-6323.129435  PMID:24685878
  - 2,438 126
Effects of low-level light therapy on facial corticosteroid addiction dermatitis: A retrospective analysis of 170 Asian patients
Qi Luan, Ling Liu, Qiangmei Wei, Bin Liu
March-April 2014, 80(2):194-194
DOI:10.4103/0378-6323.129436  PMID:24685879
  - 4,752 92
Nevus lipomatosus cutaneus superficialis associated with nevus sebaceous of Jadassohn
Enver Turan, Yavuz Yesilova, Derya Uçmak, Gül Türkçü, Özgür Ilhan Çelik, Mehmet Salih Gürel
March-April 2014, 80(2):194-194
DOI:10.4103/0378-6323.129437  PMID:24685880
  - 1,963 82
ORIGINAL ARTICLES
Validation of a computer based objective structured clinical examination in the assessment of undergraduate dermatology courses
Feroze Kaliyadan, Abdul Sattar Khan, Joel Kuruvilla, Kaberi Feroze
March-April 2014, 80(2):134-136
DOI:10.4103/0378-6323.129386  PMID:24685849
Many teaching centers have now adopted objective structured clinical examination (OSCE) as an assessment method for undergraduate dermatology courses. A modification of the standard OSCE in dermatology is computer based or electronic OSCE (eOSCE). We attempted to validate the use of a computer-based OSCE in dermatology in a group of fifth year medical students. The scores of the students in the computer-based OSCE showed a strong positive correlation with the scores on the clinical presentation (Pearson's co-efficient - 0.923, P value <0.000, significant at the 0.01 level) and a good correlation with overall scores of the student (Pearson's co-efficient - 0.728, P value <0.000, significant at the 0.01 level), indicating that this is a reliable method for assessment in dermatology. Generally, the students' feedback regarding the methods was positive.
  - 1,351 90
Drug advertisements in two dermatology journals: A critical comparison of IJDVL and JAAD
Pratik Gahalaut, Sandhya Chauhan, Nitin Mishra, Madhurkant Rastogi, Richa Thakur
March-April 2014, 80(2):115-121
DOI:10.4103/0378-6323.129381  PMID:24685846
Background: Though drug promotion regulations exist worldwide, low quality of journal drug advertising is a global issue. Medical journals are regarded as a leading source of information for new drugs. They may also modulate prescribing behavior of physicians without their knowledge. A comparative analysis of advertisements from different countries may provide insights regarding strengths and weaknesses of different regulating systems. Aims: Prescription drug advertisements from the Indian Journal of Dermatology, Venereology, and Leprology (IJDVL) and Journal of American Academy of Dermatology (JAAD) were compared to check their compliance with criteria of World Health Organization (WHO) and International Federation of Pharmaceutical Manufacturers and Associations (IFPMA). Methods: All the prescription drug advertisements of at least one page length appearing in all the issues of IJDVL and JAAD from January 2012 till December 2012 were included in this study. The contents of both advertisements were compared for compliance regarding different criteria of ethical codes for drug advertising of WHO and IFPMA. Statistical analysis was done using Fisher's exact test. Results: Compared to IJDVL, more advertisements in JAAD complied with WHO and IFPMA codes. On the whole, advertisements in IJDVL had significantly less information regarding the approved usage, dosage, abbreviated prescribing information (API), summary of scientific information, safety information regarding the drug, and references to the scientific literature to support various claims. However, JAAD had more advertisements with multiple claims than IJDVL, and many advertisements interspersed between scientific articles while IJDVL had none. Conclusion: The complex issue of ethical drug advertising in dermatology journals requires constant review and discussion. Dermatologists should be cautious in assessing any advertisement or claim even if it seems evidence-based. The results from our study highlight the need for a global, proactive and effective regulatory system to ensure ethical medicinal drug advertising in medical journals.
  - 2,143 128
A randomized placebo-controlled double-blind pilot study of methotrexate in the treatment of H1 antihistamine-resistant chronic spontaneous urticaria
Vinod K Sharma, Saurabh Singh, M Ramam, Mahesh Kumawat, Rakesh Kumar
March-April 2014, 80(2):122-128
DOI:10.4103/0378-6323.129382  PMID:24685847
Background: Chronic urticaria not responsive to antihistamines is a difficult disease to manage. Methotrexate has been used in difficult chronic urticarias with some benefit. Objective: To evaluate the efficacy of methotrexate in the treatment of chronic spontaneous urticaria poorly responsive to H1 antihistaminics. Methods: In a randomized double-blind trial at the Department of Dermatology and Venereology of a tertiary care centre, 29 patients with chronic spontaneous urticaria not responding well to H1 antihistaminics were recruited. Patients were randomly allocated to receive either a weekly dose of oral methotrexate 15 mg or placebo (calcium carbonate) for a total duration of 12 weeks, after which treatment was stopped and patients were followed up for relapse of urticaria. Each group also received levocetrizine 5 mg once daily for symptom control. Primary outcome measured was a reduction by >2/3 rd of baseline urticaria scores after 12 week therapy. Secondary outcome was a reduction in antihistamine requirement after stopping therapy. Results: Fourteen patients were randomized to the methotrexate group and fifteen patients to the placebo group. Out of 17 patients who completed therapy, the primary outcome was achieved by 3.5 ± 1.9 (out of 10) patients in the methotrexate group and by 3.67 ± 1.03 (out of 7) patients in the placebo group (P > 0.05). Ten patients followed up, after stopping therapy, for a mean period of 3.5 ± 2.4 months; 3 remained in remission and 7 had relapsed. One patient had uncontrollable nausea and vomiting after taking methotrexate and was withdrawn from the study. The placebo group did not experience any side effects. Conclusions: Methotrexate 15 mg weekly for 3 months did not provide any additional benefit over H1 antihistamines in this study but an adequately powered study with longer follow up is required to assess its utility.
  - 3,709 433
QUIZ
Multiple cutaneous nodules in a patient with rheumatoid arthritis
Wen-Hui Chen, Chien-Ping Chiang, Bai-Yao Wu
March-April 2014, 80(2):191-193
DOI:10.4103/0378-6323.129424  PMID:24685876
  - 2,255 136
VIEW POINT
Advertisements in medical journals
Vinay Kulkarni
March-April 2014, 80(2):104-105
DOI:10.4103/0378-6323.129376  PMID:24685844
  - 1,628 111
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