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   2006| January-February  | Volume 72 | Issue 1  
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Vitiligo: A sign of systemic disease
Richard H Huggins, Christopher A Janusz, Robert A Schwartz
January-February 2006, 72(1):68-71
DOI:10.4103/0378-6323.19730  PMID:16481722
Vitiligo reflects a systemic process that has important implications beyond the skin. These include other autoimmune diseases and ocular and neurological abnormalities. Alezzandrini syndrome and Vogt-Koyanagi-Harada syndrome particularly exemplify this relationship. In addition, vitiligo may be confused with other systemic disorders, including tuberous sclerosis, progressive systemic sclerosis (scleroderma), melanoma, and, in endemic regions, leprosy. We describe these associations and emphasize the importance of depigmenting disorders.
  33,175 1,163 14
Lobster-claw hand: A manifestation of EEC syndrome
MJ Cyriac, E Lashpa
January-February 2006, 72(1):54-56
DOI:10.4103/0378-6323.19721  PMID:16481713
The combination of ectrodactyly, ectodermal dysplasia, and cleft lip with or without cleft palate (EEC syndrome) is a rare type of congenital anomaly. It usually occurs as an autosomal-dominant trait or less commonly in a sporadic form. In this complex, multiple congenital anomaly syndrome, any of the three cardinal manifestations may present with variable expressions.
  22,651 296 5
Turmeric (curcumin): A widely used curry ingredient, can contribute to oxidative stress in asian patients with acute vitiligo
Karin U Schallreuter, Hartmut Rokos
January-February 2006, 72(1):57-59
DOI:10.4103/0378-6323.19722  PMID:16481714
  21,044 471 14
Comparison of the efficacy of topical 1% lindane vs 5% permethrin in scabies: A randomized, double-blind study
Omid Zargari, Javad Golchai, Abdolrasoul Sobhani, Ahmad R Dehpour, Shahriar Sadr-Ashkevari, Narges Alizadeh, Abas Darjani
January-February 2006, 72(1):33-36
DOI:10.4103/0378-6323.19715  PMID:16481707
Background: Permethrin, a pyrethroid insecticide, is not yet available in Iran and may be a useful substitute for the control of scabies in Iran. Aim: To compare the efficacy of topical lindane with topical permethrin in the treatment of scabies in a population in Iran. Methods: In a double-blind, randomized study, all consecutive patients with scabies were randomized into two groups. One group and their family contacts received 1% lindane cream, and the other group and their family contacts were treated with topical 5% permethrin cream. Subsequently, patients were followed up at 2- and 4-week post-treatment. Results: Of the 99 patients enrolled in the study, 47 patients received 1% lindane cream, and 52 patients were treated topically with 5% permethrin cream. Permethrin provided an improvement rate of 84.6% after two weeks, whereas lindane was effective only in 48.9% of patients. Conclusion: Permethrin (5%) cream was found to be significantly more effective in the treatment of scabies in comparison with lindane in this study, and it seems that it could be an alternative treatment.
  19,438 630 12
Synthetic hairs: Should they be used?
Venkataram Mysore
January-February 2006, 72(1):5-7
DOI:10.4103/0378-6323.19710  PMID:16481702
Artificial hair fibers have recently been marketed in India as an alternative method of hair restoration. However, the subject of artificial hairs is controversial, as FDA in the United States has banned them. Several side effects have been reported after their use and it is therefore important that dermatologists are aware of all aspects about these devices. This article presents the author's viewpoint on the subject and suggests guidelines for using them.
  19,469 247 -
AIDS vaccine: Present status and future challenges
PK Nigam, Manjula Kerketta
January-February 2006, 72(1):8-18
DOI:10.4103/0378-6323.19711  PMID:16481703
Development of a preventive vaccine for HIV is the best hope of controlling the AIDS pandemic. HIV has, however, proved a difficult pathogen to vaccinate against because of its very high mutation rate and capability to escape immune responses. Neutralizing antibodies that can neutralize diverse field strains have so far proved difficult to induce. Adjuvanting these vaccines with cytokine plasmids and a "prime-boost," approach is being evaluated in an effort to induce both CTL and antibody responses and thereby have immune responses active against both infected cells and free viral particles, thereby necessitating fewer doses of recombinant protein to reach maximum antibodies titers. Although obstacles exist in evaluation of candidate HIV vaccines, evidence from natural history studies, new molecular tools in virology and immunology, new adjuvants, new gene expression systems, new antigen delivery systems, recent discoveries in HIV entry and pathogenesis, and promising studies of candidate vaccines in animal models have provided reasons to hope that developing a safe and effective AIDS vaccine is possible and within reach.
  14,210 1,406 3
Two cases of subungual glomus tumor
PS Murthy, R Rajagopal, PK Kar, S Grover
January-February 2006, 72(1):47-49
DOI:10.4103/0378-6323.19719  PMID:16481711
Glomus tumors are uncommon, small, painful, and usually benign hamartomas arising from the arterial end of the glomus body. They often present early in the subungual stage because of intense pain. Two female patients with subungual glomus tumor are reported here. The intense pain associated with this tumor had led to disuse atrophy of the upper limb in one case. Hildreth's sign and Love's test were positive in both, but imaging did not help in preoperative diagnosis. Tumors were resected by transungual approach, leaving a 3-mm-wide margin. There was no recurrence after 1-year follow-up in both instances.
  15,284 294 7
Contact dermatitis to compound tincture of benzoin applied under occlusion
Chembolli Lakshmi, CR Srinivas
January-February 2006, 72(1):62-63
DOI:10.4103/0378-6323.19726  PMID:16481718
  14,074 136 3
Management of hemangiomas in children
SN Oak, Naveen Viswanath
January-February 2006, 72(1):1-4
DOI:10.4103/0378-6323.19709  PMID:16481701
  12,317 555 4
Thalidomide: Current status
Prashasti S Shanbhag, Vishalakshi Viswanath, RG Torsekar
January-February 2006, 72(1):75-80
DOI:10.4103/0378-6323.19732  PMID:16481724
  11,791 834 6
Cutaneous mastocytosis: Report of six cases
Arun C Inamadar, Aparna Palit
January-February 2006, 72(1):50-53
DOI:10.4103/0378-6323.19720  PMID:16481712
Cutaneous mastocytosis is a rare infiltrative disorder of the skin. Though often asymptomatic, systemic features may be associated with any clinical pattern of the disorder at any age group. We present our experience with six cases of cutaneous mastocytosis, including three with diffuse cutaneous mastocytosis, a rare entity.
  12,215 389 4
Map of dermatology: Web image browser for differential diagnosis in dermatology
Maged N Kamel Boulos
January-February 2006, 72(1):72-74
DOI:10.4103/0378-6323.19731  PMID:16481723
  11,292 263 6
Ichthyosis bullosa of Siemens: Response to topical tazarotene
S Rajiv, SV Rakhesh
January-February 2006, 72(1):43-46
DOI:10.4103/0378-6323.19718  PMID:16481710
In 1937, Siemens described a Dutch family with superficial blistering, flexural hyperkeratosis, and characteristic mauserung appearance. Since then, less than 20 kindreds with this condition have been described in the English dermatologic literature. A 14-year-old boy presented with history of recurrent blistering and peeling of skin since the age of 1 month, predominantly seen over limbs and trunk, often associated with secondary infection. His mother also had similar symptoms from childhood. On examination, the child had typical mauserung peeling of the skin and dirty gray hyperkeratosis in a rippled pattern over flexures. Skin biopsy from the boy showed intracorneal blistering with epidermolytic hyperkeratosis in the upper spinous layers. The typical history and clinical features along with characteristic histological findings confirmed our diagnosis of ichthyosis bullosa of Siemens. It must be differentiated from other conditions with epidermolytic hyperkeratosis and skin peeling, such as bullous ichthyosiform erythroderma of Brocq and peeling skin syndrome. Our patient responded well to 0.05% topical tazarotene gel over four weeks.
  8,639 233 6
Microdermabrasion for striae distensae
Rustom Tehrani
January-February 2006, 72(1):59-59
DOI:10.4103/0378-6323.19723  PMID:16481716
  7,960 457 1
Evaluation of functional impairment in psoriasis
Rohini Gaikwad, Sharmishtha Deshpande, Swati Raje, DV Dhamdhere, MR Ghate
January-February 2006, 72(1):37-40
DOI:10.4103/0378-6323.19716  PMID:16481708
Background: Psoriasis is a chronic disease, the course of which is punctuated by exacerbations and remissions. The impact of a chronic, relapsing, and disfiguring disease such as psoriasis on occupational, social, and other areas of functioning is substantial and needs attention. Aim: The purpose of this study was to assess the level and nature of functional impairment in psoriasis. Methods: Forty-three consecutive patients attending the dermatology clinic of a rural hospital were studied for psychiatric comorbidity and the level of functioning, using a semistructured questionnaire. Results: Psoriasis affected social functioning of 48% patients, led to decreased work efficiency in 51.1%, and to subjective distress at work in 62.8% of patients. Stress in home environment and interpersonal relationships was reported by 69.8%. Social and occupational functioning worsened with increasing severity of psoriasis after 1-year duration of illness. Patients complaining of pruritis frequently had anxiety disorders. Psychiatric comorbidity was detected in 67.4% cases. Conclusion : Substantial proportion of patients suffered deterioration of functioning, especially with increasing duration of illness. Thus, timely attention by dermatologists is needed in order to limit the disability caused by psoriasis. To achieve this, liaison with psychiatrist would be crucial along with illness education and emotional support.
  7,866 328 13
Correlation of clinical, histopathological, and microbiological findings in 60 cases of cutaneous leishmaniasis
Arfan ul Bari, Simeen ber Rahman
January-February 2006, 72(1):28-32
DOI:10.4103/0378-6323.19714  PMID:16481706
Background: In an endemic area, cutaneous leishmaniasis (CL) is largely diagnosed by its clinical appearance. Diagnostic challenge arises when the lesions appear in nonendemic area, when clinical picture is distorted, or any atypical variant is seen even in endemic regious. In developing countries like ours, the laboratory aid is not widely available and dermatologists mostly have to rely on clinical experience. Aim: The study was aimed to see the correlation of clinical, histological, and microbiological findings in clinically diagnosed cases of CL. Methods: It was an observational and descriptive study and was conducted over a period of 2 years in two dermatology centers in the country. Seventy-seven patients with clinically suspicious lesions of CL were screened and 60 of these were diagnosed as true clinical cases on the basis of criteria for clinical diagnosis. These cases were then subjected to slit skin smear and histopathological examination. Parasitologically positive and suggestive cases were recorded and descriptive statistics were used to evaluate the findings. Results: Out of 60 registered cases, 36 (60%) were smear-positive and 30 (50%) demonstrated Leishman Donovan (LD) bodies in histological sections. Twenty-six of the remaining (parasite-negative) cases showed one of the recognizable histological patterns seen in CL, 3 did not reveal any suggestive histology but responded to antimonial compound, and 1 turned out to be a case of deep mycosis. Conclusion: Considering the magnitude of the problem and limited resources of a developing country like ours, clinical diagnosis alone may be reliable enough in endemic areas.
  7,398 361 17
Vascular nevi in children
M Senthilkumar, Devinder Mohan Thappa
January-February 2006, 72(1):19-23
DOI:10.4103/0378-6323.19712  PMID:16481704
Background: Vascular nevi are cutaneous anomalies of angiogenesis and vasculogenesis resulting in various different clinical presentations. Aim: The purpose of our descriptive study was to observe the various types of vascular nevi in children and their features. Methods: A total of 4256 pediatric cases attending the dermatology OPD during the study period from August 2002 to August 2004 were screened for vascular nevi. Results: Out of these, 19 children (0.44%) had vascular nevi-17 hemangiomas of infancy (HOIs) and 2 port-wine stains. The mean age of the affected children was 1.3 years (ranging from 2.5 months to 8 years). There were 13 girls and 6 boys. Seventeen (89.5%) patients had progressing lesions and two (10.5%) had non-involuting ones. A solitary lesion was seen in ten (52.6%) cases and two to five lesions were present in five (26.3%) cases. The nevi were distributed over multiple sites in seven (36.8%) cases, the head and neck in six (31.6%) cases, the chest and lower limb in two (10.5%) cases each, and the upper limbs and genitalia in one (5.3%) case each. Among the hemangiomas of infancy, 15 (88.2%) cases of superficial type and 2 (11.8%) cases of deep type were seen. The cutaneous complications included ulceration in four cases and infection in one. Conclusions: HOIs were the most common vascular nevi of childhood.
  7,159 279 3
Parthenium dermatitis treated with azathioprine weekly pulse doses
Kaushal K Verma, Arika Bansal, G Sethuraman
January-February 2006, 72(1):24-27
DOI:10.4103/0378-6323.19713  PMID:16481705
Background: Parthenium dermatitis is a serious problem in India. Corticosteroids are the mainstay of treatment but the prolonged use of corticosteroids can cause serious side effects. Azathioprine used in daily doses has been shown to be effective. Aim: We have evaluated the effectiveness of azathioprine weekly pulse doses for the treatment of parthenium dermatitis. Methods: Twelve patients, ten males and two females, aged between 39 and 65 years (mean ± SD = 53.5 ± 8.7) having air-borne contact dermatitis to Parthenium hysterophorus for 3-19 years (mean = 6.33) were included in the study. The diagnosis in each patient was confirmed by patch-testing. The severity of the disease was determined by clinical severity score (CSS) on the basis of erythema, itching, type of lesions, and areas of body involved. Results: The pretreatment CSS in these patients varied from 29.7 to 55.5 (mean ± SD: 40.40 ± 7.95). After clinical and laboratory evaluation, the patients were treated with 300-mg azathioprine once-weekly doses for 6 months. Clinical and laboratory evaluations were repeated at weeks 1, 2, and then every 4 weeks until the end of therapy to evaluate the therapeutic response and side effects. The response was excellent (80-100% clearance of disease) in seven (58.33%) patients and good (60% clearance) in five (41.66%) patients. The post-treatment CSS decreased from the mean ± SD of 40.4 ± 7.95 to 10.9 ± 8.43 (P = 0.002). There were no significant side effects of the therapy. Conclusions: In this preliminary open study, azathioprine in weekly pulse doses has been found to be effective without any serious adverse effects in the treatment of parthenium dermatitis. The cost of therapy with this regimen is reduced by 60%.
  6,730 339 17
Adenocarcinoma of the gall bladder presenting with a cutaneous metastasis
Jasleen Kaur, Tarun Puri, PK Julka, Gowthaman Gunabushanam, Venkateswaran K Iyer, Manoj K Singh, M Ramam
January-February 2006, 72(1):64-66
DOI:10.4103/0378-6323.19728  PMID:16481720
  6,138 149 7
Nevus lipomatosus superficialis over neck, an atypical site
Jayanta Kr Das, Sujata Sengupta, Asok Kr Gangopadhyay
January-February 2006, 72(1):66-67
DOI:10.4103/0378-6323.19729  PMID:16481721
  6,124 146 3
Ultrasound biomicroscopy of the skin to detect a subclinical neuroma of the proximal nail-fold
Kalpana D Bhatt, Rui Fernandes, Rachita Dhurat
January-February 2006, 72(1):60-62
DOI:10.4103/0378-6323.19725  PMID:16481717
  6,108 141 1
Epidermolysis bullosa acquisita
Jayanta Kr Das, Sujata Sengupta, Asok Kr Gangopadhyay
January-February 2006, 72(1):86-86
  5,593 225 4
Imatinib-induced nail hyperpigmentation in chronic myeloid leukemia
K Prabhash, Ghanshyam Biswas, N Prasad, Narayan Karant, PSRK Sastry, PM Parikh
January-February 2006, 72(1):63-64
DOI:10.4103/0378-6323.19727  PMID:16481719
  5,651 164 14
All about leprosy
BK Girdhar
January-February 2006, 72(1):85-85
  5,327 214 -
Recurrent, scarring penile ulcers
L Padmavathy, K Chockalingam, Lakshmana L Rao, N Ethirajan
January-February 2006, 72(1):86-86
  5,260 101 5
Skin-colored nodules in zosteriform pattern
Ritika Gupta, Archana Singal, Deepika Pandhi
January-February 2006, 72(1):81-82
DOI:10.4103/0378-6323.19733  PMID:16481725
  5,182 142 -
Chronic zosteriform cutaneous leishmaniasis
M Omidian, MA Mapar
January-February 2006, 72(1):41-42
DOI:10.4103/0378-6323.19717  PMID:16481709
Cutaneous leishmanasis (CL) may present with unusual clinical variants such as acute paronychial, annular, palmoplantar, zosteriform, erysipeloid, and sporotrichoid. The zosteriform variant has rarely been reported. Unusual lesions may be morphologically attributed to an altered host response or owing to an atypical strain of parasites in these lesions. We report a patient with CL in a multidermatomal pattern on the back and buttock of a man in Khozestan province in the south of Iran. To our knowledge, this is the first reported case of multidermatomal zosteriform CL. It was resistant to conventional treatment but responded well to a combination of meglumine antimoniate, allopurinol, and cryotherapy.
  5,115 136 7
Cutaneous metastasis from urologic tumors
Prabhash Kumar, N Prasad, G Biswas, PM Parikh
January-February 2006, 72(1):86-86
  4,367 85 2
Stria distensae: Response by authors
Gurcharan Singh, Lekshmi P Kumar
January-February 2006, 72(1):59-60
  3,796 125 -
Linear plaque over the face
S Veeranna
January-February 2006, 72(1):83-84
DOI:10.4103/0378-6323.19734  PMID:16481726
  3,681 133 -
IJDVL is now indexed with PubMed
Uday Khopkar
January-February 2006, 72(1):87-88
  3,022 77 1
Ombudsman's Report for 2005
AK Bajaj
January-February 2006, 72(1):88-88
  2,748 67 -
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