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  Citation statistics : Table of Contents
   2003| July-August  | Volume 69 | Issue 4  
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The genus Malassezia and human disease
AC Inamadar, A Palit
July-August 2003, 69(4):265-270
Sabouraud’s Pityrosporum is now recognized as Malassezia. With taxonomic revision of the genus, newer species have been included. The role of this member of the normal human skin flora in different cutaneous and systemic disorders is becoming clearer. The immunological responses it induces in the human body are conflicting and their relevance to clinical features is yet to be explored.
  7 28,380 1,049
Clinico-mycological evaluation of onychomycosis at Bangalore and Jorhat
S Grover
July-August 2003, 69(4):284-286
Introduction: Clinical and mycological features of onychomycosis show variation with time and place. Material and Methods: A study to analyze the morphological variants and mycological isolates of onychomycosis was carried out in 50 patients attending the dermatology out-patient departments at the Air Force Hospitals at Bangalore and at Jorhat. Nail clippings were subjected to direct microscopy and cultured on Sabouraud’s Dextrose Agar. Results: The commonest age group affected (56%) was the 20-40 year age group. The fingernails alone were involved in 24 (48%) patients, the toenails alone in 15 (30%) patients, and both in 11 (22%) patients. Distal and lateral subungual onychomycosis was encountered in 41 (82%) patients, proximal superficial onychomycosis and total dystrophic onychomycosis in 3 each (6%), paronychia in 2 (4%) and superficial white onychomycosis in 1. Of the 59 samples cultured, dermatophytes were grown in 14 (23.7%), non-dermatophyte moulds (NDM) in 13 (22.0%), candida in 10 (16.8%) and no growth in 22 (37.2%) samples. Conclusion: Among the dermatophytes, Trichophyton rubrum, and among the NDM, Aspergillus spp., were the commonest isolates.
  6 5,558 307
Coexistence of disseminated superficial and giant porokeratosis of Mibelli with squamous cell carcinoma
K Hanumanthayya, S Magavi, R Tophakhane, R Rathod
July-August 2003, 69(4):296-297
Porokeratosis of Mibelli is a genetic disease transmitted as an autosomal dominant trait. The giant type of porokeratosis is a relatively rare entity and is associated with an increased risk of malignancy. The aim of this article is to present this rare case of giant porokeratosis associated with squamous cell carcinoma.
  3 4,353 161
Multiple autoimmune syndrome
MP Mohan, TC Ramesh
July-August 2003, 69(4):298-299
We report a case in which the presence of dermatological autoimmune conditions, vitiligo and alopecia areata, led to the diagnosis of a systemic autoimmune disease, ulcerative colitis.
  3 12,467 304
Comparative study of oral and topical ketoconazole therapy in pityriasis versicolor
VB Nagpal, VK Jain, K Aggarwal
July-August 2003, 69(4):287-288
Introduction: Both topical and systemic ketoconazole are reported to be effective against pityriasis versicolor. Material and Methods: Forty patients suffering from pityriasis versicolor were treated either with oral ketoconazole 200 mg per day or 2% ketoconazole cream topically once daily for 2 weeks. Results: On global assessment, after 2 weeks of start of therapy, 18 (90%) out of 20 patients treated with oral ketoconazole were cured while 2 patients had considerable residual disease. In the ketoconazole cream group, 16 (80%) out of 20 patients were cured and 4 patients had considerable residual disease. Conclusion: No significant difference was observed in the response rates in the two groups. Relapse occurred in two patients of the systemic ketoconazole group and six patients of the topical ketoconazole group during the follow-up period of three months.
  3 7,205 280
Topical lincomycin gel in acne vulgaris: A multicentric placebo controlled study
AD Sharma, PD Gupte, M Sundaram, VR Janaki, VL Rege, FE Bilimoria, J Arora
July-August 2003, 69(4):271-273
Introduction: Acne vulgaris is commonly treated with topical antibacterials. We evaluated lincomycin gel, a new topical formulation for mild to moderate acne. Material and Methods: A multicentric, randomized, double blind, placebo controlled, clinical trial was conducted with lincomycin hydrochloride in 2% gel form in 200 patients with grade II and grade III acne. The severity of acne lesions was noted at baseline and after 4 weeks. Results: About 70% cases in the study group showed a good to excellent response, which was significantly more as compared to 23% in the placebo group. The frequency and severity of adverse reactions in the two groups were similar. Conclusion: Lincomycin hydrochloride gel is an effective and safe treatment option for mild to moderate acne vulgaris.
  2 14,527 272
Comparison of oral azithromycin pulse with daily doxycycline in the treatment of acne vulgaris
MK Singhi, BC Ghiya, RK Dhabhai
July-August 2003, 69(4):274-276
Introduction: Oral azithromycin has been advocated by some in the treatment of acne. However, its efficacy has not been established. Material and Methods: This non-randomized controlled trial was conducted on 70 outpatients with acne vulgaris to compare the efficacy and safety of azithromycin and doxycycline in the treatment of inflammatory acne. In the first group, azithromycin was administered 500 mg daily before meals for 3 consecutive days in a 10-day cycle, with the remaining seven days in each cycle being drug-free days. The second group was given doxycycline 100 mg daily after meals. Topical erythromycin was prescribed to all patients. Clinical assessment was done at 10-day intervals for both the groups up to three months. We followed the severity index described by Michaelsson for assessment of outcome measures. Results: There was 77.26% improvement in azithromycin treated group in comparison to 63.74% in the doxycycline treated group. There was a statistically significant reduction in severity in the azithromycin treated group. Conclusion: The study showed that a combination of azithromycin with topical erythromycin was significantly better than doxycycline with topical erythromycin in the treatment of acne vulgaris. The incidence and severity of side effects were also lower with azithromycin.
  2 25,254 814
Profile of dermatophyte infections in Baroda
S Singh, PM Beena
July-August 2003, 69(4):281-283
Introduction: This is an attempt to find the species prevalence of various dermatophytes in patients with dermatophytosis in our hospital in Baroda. Material and Methods: Two hundred and sixty clinically suspected cases of dermatophytosis were subjected to mycological studies. Results: One hundred and fifty seven cases (60.38%) were positive for fungus in direct microscopy while 116 (44.62%) were culture positive. Tinea corporis was the most common clinical presentation followed by tinea cruris. Young adults in the age group of 16-30 yrs were mainly affected. The male to female ratio was 1.57:1. Trichophyton rubrum (73.27%) was the most common isolate, followed by Trichophyton mentagrophytes (17.24%), Epidermophyton floccosum (7.75%) and Trichophyton violaceum (1.72%). Conclusion: Trichophyton rubrum was the predominant fungus found in this area of Gujarat, followed by Trichophyton mentagrophytes, Epidermophyton floccosum and Trichophyton violaceum.
  2 9,134 640
Primary cutaneous B cell lymphoma
I Bhat, C Janaki, G Sentamilselvi, VR Janaki
July-August 2003, 69(4):289-290
A 54-year-old man, a road layer by occupation, presented with a ‘leonine facies’ and multiple tumors that were more commonly present over the exposed parts of the body. On investigation, he turned out to be a case of primary cutaneous B cell lymphoma with a distinctive histopathology. Chemotherapy was given with a good therapeutic response.
  1 7,634 153
Coconut oil compound ointment
MK Shah
July-August 2003, 69(4):303-304
  1 15,330 251
Insulin induced lipoatrophy
K Krishna, RP Mane, K Kavita
July-August 2003, 69(4):310-311
  1 4,916 106
Treatment of Schamberg’s disease with pentoxifylline
S Panda
July-August 2003, 69(4):311-312
  1 12,636 123
Treatment of pemphigus
R Gupta, S Gupta
July-August 2003, 69(4):314-314
  1 3,398 214
Response by the author
C Balachandran
July-August 2003, 69(4):314-315
  1 2,429 60
Safety and efficacy of adapalene gel 0.1% in acne vulgaris: Results of a post-marketing surveillance study
SH Percy
July-August 2003, 69(4):277-280
Introduction: Adapalene is a novel retinoid indicated for the topical treatment of acne vulgaris. The drug was introduced in India in 2001. Aims: A post-marketing surveillance study was conducted to assess the safety and efficacy of adapalene gel 0.1% when used as monotherapy or in combination with other anti-acne agents in Indian patients of acne vulgaris. Material and Methods: A 12-week, multicentre, open-label, non-comparative study involving 571 patients from 21 centers across India was conducted between January and September of 2002. Concomitant prescription of other anti-acne drugs was permitted, if needed. Results: Of the 571 patients, 441 completed the treatment as per protocol. At the end of therapy, 96.3% of patients showed an improvement in their acne from baseline, with greater than 75% improvement seen in two-thirds of patients. Adverse events were reported in 24% of the patients, none of which were serious. The tolerability of therapy was rated as excellent/good in 81% of patients by physicians and in 78% by the patients. Conclusion: Adapalene gel 0.1% is a safe and effective topical agent in the treatment of mild to moderate acne vulgaris in Indian patients. It may be safely combined with other topical and oral anti-acne agents.
  1 52,191 828
A recurrent swelling of the scalp
H Devalia, R Rao, A Zaidi
July-August 2003, 69(4):307-308
  1 8,984 124
Greither’s disease
SB Athanikar, AC Inamadar, A Palit, VV Sampagavi, NS Deshmukh
July-August 2003, 69(4):292-293
A 14-year-old girl with diffuse palmoplantar keratoderma with hyperhidrosis and progressive extension of keratoderma to the dorsum of the hands and feet is reported. The inheritance pattern was autosomal dominant.
  - 9,354 198
Non-bullous variant of bullous pemphigoid: Role of immunofluorescence in diagnosis
A Goel, C Balchandran, SD Shenoi, SB Pai
July-August 2003, 69(4):294-295
An elderly lady presented with persistent and unexplained excoriated lesions on trunk and limbs of 4 years’ duration. No vesicles or bullae ever developed during the course of the disease. Histopathology showed nonspecific dermatitis. The diagnosis of bullous pemphigoid was confirmed by immunofluorescence. The patient responded well to topical steroids and dapsone.
  - 6,840 203
Nail involvement in degenerative collagenous plaques of the hands
B Jeevankumar, DM Thappa, S Jayanthi
July-August 2003, 69(4):309-310
  - 4,232 81
Response from the author
V Gandhi
July-August 2003, 69(4):313-314
  - 3,285 54
Ethics Committee
G Tyebkhan
July-August 2003, 69(4):300-302
  - 5,803 215
Drugs in dermatological practice: Relationship to food
S Prabhu, SD Shenoi
July-August 2003, 69(4):305-306
  - 2,825 130
Online since 15th March '04
Published by Wolters Kluwer - Medknow