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  Citation statistics : Table of Contents
   2002| March-April  | Volume 68 | Issue 2  
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Minimal erythema dose (Med) to narrow band ultraviolet - B (NB-UVB) broad band ultraviolet-B (BB-UVB) - A pilot study
Serish , CR Srinivas
March-April 2002, 68(2):63-64
Phototherapy is an effective treatment for various dermatological conditions. Ultraviolet B (290 - 320nm) is reported effective in the treatment of psoriasis. Narrow band UVB (NB-UVB) is also reported effective in the treatment of psoriasis and vitiligo. To standardize the dosage schedule for NB-UVB we undertook this study to determine the minimal erythema dose (MED) on type IV and Indian skin. On six volunteers tested the MED for NB-UVB ranged between 150mj and 400mj and for BB-UVB ranged between 10mj and 35mj. The mean MED for NB was 300mj and BB was 21 mj, the mean ratio of NB to BB was 1:15. We propose that narrow band UVB is a practical alternative to the conventional broad band UVB and has the advantage over photochemotherapy (PUVA) of being effective without prior administration of psoralen.
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Changing trends in sexually transmitted diseases in North Eastern India
AK Jaiswal, S Banerjee, AR Matety, S Grover
March-April 2002, 68(2):65-66
A retrospective data analysis was carried out to find the trends in frequency and distribution of different STDs in North Eastern (NE) India during 1995 - 1999. The commonest STD was chancroid (25.7%) followed by condylomata acuminata (CA), nongonococcal urethritis (NGU), lymphogranuloma venereum (LGV), syphilis, gonorrhoea (GONO), herpes genitalis (HG), mixed infection (MI) and balanoposthitis (BP). Interestingly no case of donovanosis (Dono) was seen. HIV infection accounted for 9.62% of the total STD patients. A comparison of the present data with that reported a decade back (1986 - 1990) revealed a sharp decline in the incidence of syphilis, chancroid, GONO, whereas a conspicuous upward trend in CA and NGU. Factors responsible for these variations are analysed briefly.
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A clinical study of vitiligo
Jacintha Martis, Ramesh Bhat, B Nandakishore, JN Shetty
March-April 2002, 68(2):92-93
A clinical study of one hundred patients having vitiligo revealed the incidence among new patients to be 1.84%. The male/female ratio was 1:1.22. Family history of vitiligo was available in 8% of our patients. The different morphological pattern consisted of vitiligo vulgaris (39 cases), focal vitiligo (27 cases), acrofacial vitiligo (18 cases), lip - tip vitiligo (7 cases), lip vitiligo (5 cases), segmental vitiligo (3 cases) and universal vitiligo (1 case). Associated diseases include atopic dermatitis (2 cases), Hansen s disease (2 cases), alopecia areata (1 case), halo naevus (1 case), chronic urticaria (1 case), lichen planus (1 case), diabetes mellitus (9 cases), hypertension (4 cases), hypothyroidism (2 cases), epilepsy (1 case) and IHD (1 case).
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Five years experience of photopatch testing in 50 patients
Pramila A Kanchan, Shrutakirthi D Shenoi, C Balachandran
March-April 2002, 68(2):86-87
Photopatch testing with Scandinavian photopatch series was done in 50 patients with photodermatitis. The frequent photosensitisers were musk ambrette, chlorpromazine, promethazine, and PABA.
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Efficacy of H, antihistamine, corticosteroids and cyclophosphamide in the treatment of chronic dermographic urticaria
Rajesh Kumar, Kaushal K Verma, JS Pasricha
March-April 2002, 68(2):88-91
H, antihistamines relieve urticaria by blocking the action of histamine on the target tissue, while demonstration of autoantibodies in the sera of a proportion of the patients having chronic idiopathic urticaria, use of immunosuppressive drugs for the treatment of these patients has acquired the greater rationality. We evaluated the role of corticosteroids and cyclophosphamide in the treatment of chronic dermographic urticaria. Twenty-five patients, 13 males and 12 females, between 18-53 years in age, having chronic dermographic urticaria were taken up for this study. The patients were divided into three groups. Group I patients (n=9) were treated with cetirizine hydrochloride 10 mg per day orally, group II patients (n=7) were treated with betamethasone 2 mg along with cyclophosphamide 50 mg along with cetirizine 10 mg per day for a total period of 4 weeks. The patients were evaluated every week to record the therapeutic response and side effects, and then followed up without treatment for a period of 6 months to look for recurrence of the urticaria, if any. Six patients in group I and all the patients in group II and group III had complete remission while the remaining patients in group I had partial relief. The side effects included drowsiness in 4 patients. All the patients in group II had weight gain, 4 patients had acne and 2 patients developed cushingoid features. Majority of the patients relapsed within 3 days after stopping the treatment. Supplementation of the treatment with oral corticosteroids or cyclophosphamide was more effective in controlling the symptoms as compared to cetirizine alone. But a four weeks supplementation was not adequate for preventing the relapses when the drugs were withdrawn.
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Painless piezogenic pedal papules in a patient with rheumatic heart disease
SK Singh, M Tehseen, A Kalam
March-April 2002, 68(2):107-108
A 14-year - old female with rheumatic heart disease presented with multiple painless, non - itchy papules on her heel. Painless papules consisted of normal fat tissues.
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Pigmented xerodermoid
M Ramesh Bhat, Sanjay Maman Cherian, JN Shetty
March-April 2002, 68(2):103-103
An 18- year-old female who presented with features suggestive of pigmented xerodermoid is reported.
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Bilateral nevus of ota with oral mucosal involvement
Sanjay K Rathi
March-April 2002, 68(2):104-104
A 30-year-old female presented with asymptomatic slate brown hyperpigmented diffuse macules on both the cheeks, nose, forehead, eyelids, sclera, conjunctiva and hard palate since early childhood. Nevus of Ota, are in Indian subcontinent, commonly occurs unilaterally on face. This case is being reported for its rarity and extensive involvement.
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Tuberous xanthomas in type IIA hyperlipoproteinemia
K Krishna Mohan, K Dileep Kumar, BV Ramachandra
March-April 2002, 68(2):105-106
A 4 - year -old obese girl with multiple yellowish, plaques and nodular lesions showed features of tuberous xanthomato in Type IIa hyperlipoproteinemia.
  1 6,936 0
Apoptosis: Its significance in dermatology
Anil H Patki
March-April 2002, 68(2):59-62
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Treatment of nevus of OTA by Q-switched, frequency doubled, ND: Yag laser
National Skin and Hair Care Centre , HM Omprakash
March-April 2002, 68(2):94-95
Nevus of Ota is a dermal melanocytic nevus for which hitherto no effective therapy was available. Lasers have been successfully tried for ablation. But there is no Indian experience till date. Q- Switched, Frequency Doubled, Nd: YAG Laser was installed at our centre an year ago. The first operated case, which has shown near complete pigment dilution, is being presented. The patient underwent three treatments with a minimum of 2 months between sessions. Pre and post therapy photographs were taken and side effects documented. The patient has shown near complete pigment dilution after 3 treatments. Q-Switched, Frequency Doubled, Nd: YAG Laser is effective in treating Nevus of Ota in the Indian skin types. There are no complications noticed till date in our experience.
  1 14,566 0
Silent neuropathy in leprosy
S Jena, S Mishra, G Mohanty
March-April 2002, 68(2):84-85
Twelve patients of silent neuropathy attending the OPD of Skin and VD, VSS Medical College Hospital during 1996 - 1998 were taken for study. On clinical analysis 5 cases were present as silent neuropathy, 4 cases during MDT and 3 cases after completion of MDT Seventy percent of cases showed good response to systemic steroid.
  1 6,195 1
Acanthosis nigricans: A dermatologic marker of metabolic disease
PK Varthakavi, A Waingankar, KL Patel, SL Wadhwa, U Khopkar, RA Sengupta, PC Merchant, SD Mehtalia, KD Nihalani
March-April 2002, 68(2):67-72
Most patients with acanthosis nigricans have either clinical or subclinical insulin resistance. We undertook a study to estimate the insulin sensitivity of a group of patients referred from the dermatologist with biopsy proven acanthosis nigricans. Thirty- six patients were evaluated in the Endocrinology clinic. Plasma glucose and serum Insulin levels were estimated after a 75 gms oral glucose load (OGTT). An intravenous Insulin Tolerance Test (ITT) was performed with measurement of Glucose Disposal Rate (GDR). There were 28 females and 8 males (M:F - 3.5:1; mean age 26.3+/-1.7 years) in the study. 25/36 patients were morbidly obese (BMI-36.0 +/- 1.2 Kg/m2) with an abnormal body fat distribution (WH ratio - 0.9 +/ - 0.02). One patient had generalized lipoatrophy. 16/36 patients with acanthosis nigricans had IGT or overt diabetes and all had highly significant hyperinsulinemia (AUCI= 20825 +/ 1287.7 vs. 6340.0+/- 984.2 mIU/ml/hr in controls, p < 0.0005). The GDR in patients with acanthosis nigricans was reduced (-0.66+/-0.07) compared to controls (-0.39+/- 0.08; p < 0.01). There was a significant positive correlation between indices of adiposity and insulin resistance in subjects with impaired tolerance.
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Evaluation of the efficacy and safety of fexofenadine in the management of chronic idiopathic urticaria: A prospective study with 512 patients
Sandipan Dhar, Debasis Basu, Goutam Mistri, Prakash K Hazra, Subrata Malakar, Ajit K Dutta
March-April 2002, 68(2):73-76
Five hundred and twelve patients with chronic idiopathic urticaria (CIU) were treated with fexofenadine at a dose on 180mg/day. Maximum number of patients were between 20 to 40 years of age and female to male ratio was 1.45:1. The severity of itching was calculated on a scale of 0 to 4 and was recorded by the patients. The mean daily total symptom score (TSS) was measured as sum of the patients' pruritus and number of wheal scores (0 to 7). A mean TSS was determined for each week. Baseline TSS came down to '0' by 4 weeks in all groups except those with TSS 4. There was no correlation between the baseline TSS and degree of improvement. Of 512, 14 (2.73%) patients did not complete the study. The commonest adverse effect was headache (9.04%). There was no report of drowsiness or cardiac arrythmia. In no patient fexofenadine had to be withdrawn because of its adverse effects.
  1 7,428 4
"Differential diagnosis of leprosy" a guide book for histopathologists
T Gopinathan
March-April 2002, 68(2):112-112
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Chevron nail and atopic dermatitis: An incidental association
Subrata Malakar, Rita Shah Malakar
March-April 2002, 68(2):106-107
Chevron nail is a nail surface pattern where V- shaped bar or bars are present on the nail plate. We describe 3 patients having atopy associated with this new nail pattern.
  - 5,860 8
Metronidazole causing fixed drug eruption
SK Arora
March-April 2002, 68(2):108-109
A rare case of fixed drug eruption due to metronidazole is reported.
  - 4,578 0
Indolent ulcers of leg and foot in Klinefelter's syndrome associated with straight back syndrome
K Muhammed, B Sofia
March-April 2002, 68(2):109-111
A 30 - year -old male who presented with indolent leg and foot ulcers, on investigation was found to have Klinefelter's syndrome associated with straight back syndrome.
  - 6,093 0
Generalised cutis laxa
Sanjay V Mukhi, Maria Kuruvila, Pushpalatha K Pai
March-April 2002, 68(2):100-101
A 44 - year -old man presented with generalised progressive lax skin of 14 years duration associated with dysphagia, joint pains and hoarseness of voice. Examination revealed "blood hound" like facies, lox skin with loss of elasticity, dilated tortuous superficial vessels over extremities and back. Systemic involvement noted were oesophageal and pharyngeal diverticuli, inguinal hernia and dermatochalasis. Skin biopsy using Verhoeff Van Gieson's stain was suggestive of cutis laxa.
  - 4,330 0
Connective tissue naevus
Carol Z Fernandes, Jacintha Martis, M Ramesh Bhat, JN Shetty
March-April 2002, 68(2):102-102
A case of non hereditary connective tissue naevus without any association with systemic complaints, in a 20 - year old male is reported.
  - 4,041 0
Multiple lentigenes syndrome
RP Sharma, SP Singh
March-April 2002, 68(2):97-98
A 23-year-old male with multiple lentigenes, pulmonary stenosis, hyperelasticity of skin, hypermobile metacarpophalangeal joints is reported as a forme fruste form of leopard syndrome.
  - 5,170 0
Eruptive collagenoma
Sanjay V Mukhi, Pramod Kumar, D Yuvarajkumar, CV Raghuveer
March-April 2002, 68(2):98-99
A case of eruptive collagenoma in a male is being reported. He presented with asymptomatic nodules and plaques over the trunk, upper extremity and face of 15 years duration. Family history was negative. Histopathology with H & E stain followed by Verhoeff van Gieson s staining revealed increased collagen in dermis confirming the diagnosis of eruptive collagenoma. Patient also had Beckers naevus.
  - 5,960 0
Primary syphilis
K Pavithran
March-April 2002, 68(2):96-96
  - 5,633 0
Journal club: Can faculty be role model for residents?
Garehaity R Kanthraj, Kariligi Siddalingappa
March-April 2002, 68(2):115-115
  - 2,745 0
Inoculation leprosy after tattooing
RR Mittal, Anju Singla, Rajan Gupta
March-April 2002, 68(2):116-116
  - 4,143 0
Psoralen induced photo onycholysis
P VS Prasad
March-April 2002, 68(2):116-117
  - 3,685 0
Slip between prescription and dispensation
Renna Rai, Narasimha Sharma, CR Srinivas
March-April 2002, 68(2):117-117
  - 2,826 0
Patch test with ether extracts in salicaceae allergy
M PS Sawhney
March-April 2002, 68(2):77-77
A total of 23 cases suggestive of airborne contact dermatitis were patch tested with ether extracts of flowers and leaves of populus sp. and salix sp. in a study conducted in Ladakh at an altitude of 3445 meters above sea level. Overall positivity was found in 12 (52.17%), with populus sp. alone in 7 (30. 43%), salix sp. alone in 4 17.39%) and to both in one (8.33%).
  - 5,031 4
A comparative clinical study of sisomicin cream versus mupirocin ointment in pyodermas
Chetan Oberai, S Shailendra, Darchan Dalal, DJ Patil, Rajshri Patil, Deepak Umrigar, Sandip Chowdhury
March-April 2002, 68(2):78-81
This study was designed to compare the efficacy and safety of sisomicin cream (0.1%) or mupirocin ointment (2%) in the treatment of primary or secondary pyodermas requiring topical antibiotic therapy alone. In the evaluable patients (n=290), impetigo was the commonest clinical condition reported. Staphylococcus aureus was the commonest pathogen isolated from the lesons. Both sisomicin and mupirocin treatments produced a steady improvement in the scores of erythema, oedema, vesiculation, pustulation, crusting and scaling but the improvement produced by sisomicin was quicker and more pronounced. The percentage of patients with complete clearing of all lesions was also higher with sisomicin than with mupirocin on days 4, 8 and 14. Patients subjectively rated the sisomicin formulation as excellent in 75% of cases as against 59% with mupirocin. Sisomicin and mupirocin are effective and safe in the management of pyodermas; however sisomicin therapy resulted in faster and greater relief of signs and symptoms.
  - 16,134 0
A study on the present scenario of STD management in an urban clinic in Kolkata
Sadhan Kumar Ghosh
March-April 2002, 68(2):82-83
A total of 4129 patients attended the STD clinic from 1996 to 1999. Of those 25.75% were STD cases. Male and female cases comprised 86% and 14% respectively. Majority were in the age group between 18 to 38 years. Choncroid was the commonest STD (37. 7%). Other STDs in order were syphilis (30. 66%), NGU (15.71%), gonorrhoea (7%), venereal wart (3.57%), candidiasis (2.53%), trichomonal vaginitis (1.6%), herpes genitalis (0.65%) and LGV (0.47%). No case of Donovanosis or HIV was detected. 13.7% of STD cases were reactive for VDRL test and 8% of the antenatal attendents were strongly VDRL test reactive. The urethral discharge on gram staining was positive for gonococcus, in 29%. 68% of the clinic attendents were given safer sex education and served condom.
  - 6,002 8
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