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   2001| September-October  | Volume 67 | Issue 5  
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Use of polymerase chain reaction (PCR) for detection of Chlamydia trachomatis infection in cervical swab samples
Jayanti Mania-Pramanik, UM Donde, Anurupa Maitra
September-October 2001, 67(5):246-250
A polymerase chain reaction (PCR) based method has been set up for detection of Chlamydia trachomatis (C. trachomatis) infection in single cervical swab samples. A primer pair specific to the major outer membrane protein (MOMP) gene common to all serotypes of C. trachomatis was used. This method was validated for its sensitivity as well as specificity. A minimum Ing of DNA could be used for detection of the infection. Specificity of the method was confirmed by carrying out a sample dilution curve. The cervical swab samples analysed in the present study were in coded form for validation of the PCR with an established commercial ELISA (Chlamydiazyme). Both the sensitivity and specificity of PCR was 100% when the ELISA results of these samples were decoded. Thus, this PCR technique could be used for better diagnosis of C. trachomatis infection in comparison to the commercially available ELISA technique.
  15,705 12 -
Low molecular weight dextran
S Smitha Prabhu
September-October 2001, 67(5):228-230
  15,304 0 -
Progeria (Hutchison - Gilford syndrome) in siblings: In an autosomal recessive pattern of inheritance
Tanjore Y Raghu, Golla A Venkatesulu, Garehathy R Kantharaj, Tamraparni Suresh, V Veeresh, Yenigi Hanumanthappa
September-October 2001, 67(5):261-262
Progeria is an autosomal dominant, premature aging syndrome. Six and three year old female siblings had sclcrodermatous changes over the extremities, alopecia, beaked nose, prominent veins and bird-like facies. Radiological features were consistent with features of progeria. The present case highlights rarity of progeria in siblings with a possible autosomal recessive pattern.
  15,056 5 -
Efficacy of itraconazole in the treatment of tinea versicolor
Juthika Mohanty, J Sethi, MK Sharma
September-October 2001, 67(5):240-241
Twenty adult patients (15 males and 5 females) with extensive, clinically diagnosed tinea versicolor (TV.) resistant to topical agents, of long duration were selected. Laboratory investigations like KOH smear, routine haemogram, LFT, and RFT were done. They were given itraconazole (100 mg) orally twice daily for 5-7 days and followed up at the end of 1 week and again three weeks later. After one week itching, erythema and scaling subsided in 80% of cases. There was no recurrence during one year follow up.
  12,778 8 -
Penile trauma
PM Abdul Gaffoor
September-October 2001, 67(5):268-269
A case of trauma of the glans peins close to external urinary meatus caused by the sharp pubic hair of the partner during sexual inercourse is discussed.
  12,390 0 -
Chalmydia trachomatis infection among asymptomatic males in an infertility clinic
J Mania - Pramanik, J Gokral, PK Meherji
September-October 2001, 67(5):242-245
Chlamydia trachomatis can lead to a variety of complications including tubal infertility. Similarly asymptomatic infection in male partner can also hinder conception. The prevalence of this infection among the infertile female in the Institute's Infertility Clinic was observed to be 34%. Hence the present study was undertaken to find out these infection among the asymptomatic male partners of these infected women. Fifteen asymptomatic males who were not treated with any antibiotics in recent past were enrolled. First voided urine, semen and blood were collected from each individual for diagnosis of this infection. Chlamydia antigen was detected in 33.3% while Chlamydia antibody was detected in seven (46.7%) of these cases. Of these seven, three cases were positive for antigen. This preliminary observation suggests that amongst the infertile couple a sizable percentage (60%) of asymptomatic male partners remain infected with Chlamydia trachomatis.
  8,804 13 -
Intraoral giant condyloma acuminatum
RR Gupta, U PS Puri, BB Mahajan, SS Sahni, G Garg
September-October 2001, 67(5):264-265
A case of intraoral giant condyloma acuminatum is reported in a 50- year- old Indian. He did not respond to topical application of podophyllin 20% but responded partially to electric cauterisation. Surgical excision was done to get rid of the warty growh completely. Since there were no skin or genital lesions and no history of marital or extramarital sexual contact the lesion was probably acquired from environmental sources. Nonsexual transmission should be considered especially when the lesions are extragenital.
  8,724 1 -
Immunopathology of skin lesions
Nazoora Khan, Veena Maheshwari, Indu Trivedi, Abul Kalam
September-October 2001, 67(5):234-237
A study was conducted on 130 patients suffering from skin lesions which included psoriasis, lichen planus, DLE, pemphigus, vitiligo and alopecia areata. Forty age-and-sex-matched healthy individuals served as control. Serum IgG, IgM, and circulating immune complexes (CIC) were estimated. Significant increase in serum IgG (1937.2 1030.43 mg%) and IgM (232.12 136.98 mg%) was observed in all the skin lesions when compared with controls except in lichen planus where they were significantly lowered, values being 580.61 77.35 mg% and 66.88 6.59mg% respectively. CIC levels were significantly raised (P<0.00 1) in various skin lesions (40.4923.29) when compared with controls (17.68 3.21), but no significance was observed in lichen planus( 17.72 4.28). Serum IgG, IgM and CIC were statistically significantly altered depending on the extent of the lesion and lowered significantly to almost normal values following treatment, thereby confirming the role of immunity in the pathogenesis of these skin disorders.
  6,807 3 -
Urethritis in males
K Pavithran
September-October 2001, 67(5):255-255
  6,512 4 -
Isolated pemphigus vegetans of the tongue
Puneet Bhargava, CM Kuldeep, NK Mathur
September-October 2001, 67(5):267-267
Pemphigus vegetans affecting only the tongue is reported in a 35-year-old woman
  6,003 16 -
Primary pachydermoperiostosis associated with Menetrier's disease
T SS Lakshmi, P Narasimha Rao, Motilal Nagaria
September-October 2001, 67(5):256-258
Primary pachydermoperiostosis and Menetrier's disease are both hypertrophic conditions of skin and mucous membrane respectively. Here we report a case of association of these two conditions in a 30 -year- old man.
  5,960 0 -
Atopy and alopecia areata in North Indians
S Sukhjot, Vinod Kumar Sharma, Lata Kumar, Bhushan Kumar
September-October 2001, 67(5):231-233
This study was undertaken with the aim of evaluating the effect of associated atopy on severity and age at onset of alopecia areata in north Indians. Presence of atopy was elicited by detailed history, examination and intracutaneous tests. Chisquare test was carried out to evaluate statistical significance. One hundred patients (76 males and 24 females) with alopecia areata were evaluated. Historical evidence of atopy was present in 50 including patients alone (23), Patients and first degree relatives (11) and first degree relatives alone (16). Intracutaneous tests were positive in 23 out of 50 patients tested randomly. There was a trend towards increasing frequency of severe alopecia as evidence of atopy became stronger e.g. both patient and first degree relative with atopy or positive intracutaneous test but results did not attain statistical significance.Similarly the onset and duration of alopecia areata was not significantly related to the presence of atopy. It is concluded that in north Indians with alopecia areata, the presence of atopy is not significantly associated with severe alopecia or onset at younger age.
  5,815 2 -
Angiokeratoma of tongue
Puneet Bhargava, Seema Bhargava, Deepak Mathur, US Agarwal, Rishi Bhargava
September-October 2001, 67(5):270-270
An 8-year-old male child who presented with lesions of angiokeratoma on tongue is described.
  5,465 2 -
Alka Dogra, GS Bajwa, Navjot Bajwa, Shallu Khurana
September-October 2001, 67(5):271-272
A case of alkaptonuria, a rare autosomal recessive metabolic disorder is being reported. The patient presented with passage of dark coloured urine, cutaneous and scleral pigmentation and joint pains. The diagnosis was confirmed by the detection of homogentisic acid in the urine.
  5,263 3 -
Acquired digital fibrokeratoma
T Salim, C Balachandran
September-October 2001, 67(5):273-273
  5,164 1 -
Med estimation for narrow band UV-B on type IV and type V skin in India
Ganesh S Pai
September-October 2001, 67(5):251-252
With an aim to determine minimum erythema dose of narrow band UV-B, 30 subjects, 20 with type I V skin and 10 with type V skin were subjected to graded incremental doses of 311-narrow band UV-B phototherapy cabinet by Daavlin. Barely perceptible erythema 24 hrs after exposure was taken as MED. 33.3% developed erythema at 745mj, 26.6% at 620mj, 23.3% at 1075mj, and 10% at 1290mj. The average MED for narrow band UV-B exposure for type I V skin was 600mj, [range 515-755mj] and for type V skin 1100 mj [range 895-1290mj] Better therapeutic response can be obtained by approximately 360 -450mj as initial irradiation dose for type IV skin and 600-825mj for type V skin.
  5,154 1 -
A study of drug eruptions by provocative tests
J Das, AC Mandal
September-October 2001, 67(5):238-239
Sixty cases of drug eruptions were observed during the period of one year. The incidence of drug eruption was 0.47% amongst all Dermatology O.P.D. attendances. Male to female ratio was 7:3. The highest number of cases were seen in the age group of 21-30 years. Fixed drug eruptions were the most frequent (58.3%), followed by urticaria and angioedema (20%). The drug sulphonamides (including co-trimoxazole) accounted for the highest number of eruptions (35%). The other drugs which were responsible for the eruptions, in order of frequency, were oxyphenbutazone, ampicillin, analgin, penicillin, tetracycline, ibuprofen, paracetamol, phenylbutazone, acetaminophen and phenobarbitone. The causative drug (s) were confirmed by provocation tests in 42 (70%) cases.
  4,771 4 -
Carbamate pesticide induced toxic epidermal necrolysis
N Rajendran, PC Chitfambalam, AM Jayaraman
September-October 2001, 67(5):253-254
A 36-year-old male alleged to have consumed carbamate pesticide liquid (Baygon@) developed toxic epidermal necrolysis (TEN) within twenty-four hours of intake. Though drugs have been commonly incriminated as offending agents for TEN, carbamate pesticide was found to be the causative agent in our case.
  4,446 0 -
Pyoderma gangrenosum and urinary tract infection
A Chopra, A Jha, D Chopra
September-October 2001, 67(5):259-260
A case of pyoderma gangrenosum is reported in a 52 - year - old man who had skin lesions without any association. On investigation urinary tract infection was detected. Treatment of UTI led to spontaneous healing of the lesions in short period thus avoiding the need of oral corticosteroids.
  4,336 4 -
Vitiligo associated with cutaneous amyloidosis
V Rajkumar, R Okade, N Chakrabarty, K Yellappa
September-October 2001, 67(5):263-263
Vitiligo is known to be associated with a variety of dermatoses and systemic diseases. We describe a case of vitiligo developing in a patient having cutaneous amyloidosis. To our knowledge this is the first report of its kind in the literature.
  4,024 5 -
Embryonic tail
Arun C Inamadar
September-October 2001, 67(5):266-266
An 8 - year- old male child with congenital, pedunculated, tail - like lesion in lumbosacral area is reported. Surgical, excision was done, as there were no radiological abnormalities underneath.
  3,794 0 -
Online since 15th March '04
Published by Wolters Kluwer - Medknow