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   1997| November-December  | Volume 63 | Issue 6  
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Dexamethasone - Cyclophosphamide pulse (DCP) therapy in Pemphigus
Renu Roy, G Kalla
November-December 1997, 63(6):354-356
Of the 37 patients enrolled for this treatment, 13 have been lost to follow up and 4 have died. Of the remaining 20, 8 are already in remission (40%), while 12 are still having active disease. Of the 8 patients who are now in remission, 1 is in phase II and taking monthly dexamethasone cyclophosphamide pulse and 50 mg cyclophosphamide daily while in 3 patients all the treatment has already been withdrawn (phase IV). All these patients are being followed up for any recurrence. The duration of remission has been more than 6 months in 7 patients (maximum 2 years). The chief side-effect observed was increased susceptibility to pyogenic and candidal infections of the skin and oral mucosa respectively. The other side-effects noted were generalized weakness and lethargy following DCP (1), irregular menstrual periods (1), amenorrhoea (1), general darkening of complexion (1), steroid psychosis (1), transient eosinophilia (1) and marked transient oligospermia.
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Tinea versicolor localized to dorsal surface of hands and feet - A rare presentation in childhood
Puneet Bhargava, CM Kuldeep, NK Mathur
November-December 1997, 63(6):382-383
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Psoriatic arthropathy : A clinical and biochemical study
EG Anuja, PA Sarojini
November-December 1997, 63(6):357-360
39 psoriatic patients with arthropathy and a negative rheumatoid factor were analysed to find the types of arthropathy and psoriasis and also any associated bichemical changes which could indicate the risk of developing arthropathy. All 5 types of arthropathy were noted, though the asymmetrical mono or oligo articular type was the most common and psoriasis vulgaris with nail involvement was more commonly associated with arthropathy. A significant association between serum hypocalcemia and psoriatic arthropathy was observed.
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"Immunoperoxidase" an essential modality of immunohistochemistry
PD Gupta, A Rapose
November-December 1997, 63(6):361-365
The immunoperoxide (IP) technique can be used for the detection of immune deposits in various tissue pathologies. This article focusses on the standardization of the reagents anti IgG, anti IgA and anti C3C which are used to target these immune deposits. Lymph node tissue was used as substrate for standardization of anti IgG and anti IgM. For anti IgA, intestine was used while for anti C3C kidney tissue rapidly proliferating glomerulo nephritis - RPGN was utilized. Sensitivity of the technique was found to be high. Also the results on paraffin section were excellent and could be interpreted using simple light microscope. It is concluded that once standardization is achieved, IP can be used as an essential modality in the detection of immune deposits in a wide variety of immunologically mediated dermatologic disorders.
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Mycobacterium Fortuitum in Cutaneous Infections
BM Hemashettar, AM Pandit, B Siddaramappa, Manjun
November-December 1997, 63(6):376-378
Three cases of culture proven primary cutaneous infections caused by Mycobacterium fortuitum, a rapidly growing non tuberculous mycobacterium, are reported. The first case was treated with ciprofloxacin and the other two, with trimethoprim / sulphamethoxazole with an excellent outcome.
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Yoga introducing as alternative medicine in some dermatological ailments
BR Baishya
November-December 1997, 63(6):389-390
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Cutaneous horn overlying psoriasis
SR Sengupta, Koushik Lahiri, PK Gupta
November-December 1997, 63(6):366-367
A 32-year old man presented with erythematous papulosquamous lesions on the body with multiple horns of varying size and shape on scalp.
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A new effective topical therapy for aphthous stomatitis
BR Baishya
November-December 1997, 63(6):383-384
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Lepromin response with dharmendra antigen in patients with leprosy
J Mohanty, HC Mohanty
November-December 1997, 63(6):385-387
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Enhanced Toxicity Potential of a Regimen on Addition of Doxorubicin in Combination Chemo-therapy
AM Vimala
November-December 1997, 63(6):347-353
A comparative study of cutaneous toxicities of two different commonly used combination chemotherapeutic regimens was conducted on 16 patients of non-Hodgkin's lymphoma. The common drugs in the two regimens were cyclophosphamide, vincristine and prednisone. One of the regimens which was administered to 10 patients, included doxorubicin as an additional drug. This combination is preferred in high grade malignancy. However, the addition of doxorubicin resulted in enhanced severity and multiplicity of cutaneous manifestations. If it is possible to choose between two or more regimens for a given malignancy, the risk-benefit ratio can be weighed to choose the appropriate and least toxic drugs.
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Smooth muscle hamartoma associated with bilateral becker's nevus
DM Thappa, CS Sirka, S Srikanth
November-December 1997, 63(6):387-389
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Diffuse cutaneous mastocytosis without systemic involvement : Response to topical augmented betamethasone dipropionate under plastic occlusion
Sudha Sarraf, Sanjay Singh, Mohan Kumar, SS Pandey
November-December 1997, 63(6):384-385
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Unusual presentation of T-cell lymphoma
J Mona Pandya, C Ranjan Rawal, FE Bilimoria
November-December 1997, 63(6):370-372
A 56-year old woman developed multiple papules, plaques and erythema - multiforme (EM) like lesions on palms, soles, abdomen, back, axillary and gluteal folds of one month duration. She also had erythematous plaques, painful necrotising ulcers and oro-genital ulcerations. Skin biopsy was suggestive of plaque stage of cutaneous T-cell lymphoma.
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Familial syringoma
LK Gupta, M Raman
November-December 1997, 63(6):373-375
Three patients with a family history of syringomas seen over a 12-month period are reported. Familial syringomas may not be as rare as generally believed.
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Incontinentia pigmenti
Pramod Agarwal
November-December 1997, 63(6):368-369
A case of incontinentia pigmenti, a rare genodermatosis is being reported from Kingdom of Saudi Arabia.
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Widespread dissemination of warts in prexisting dermatoses
Somesh Gupta, Usha Gupta, NK Tiwari, PK Saraswat
November-December 1997, 63(6):390-391
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Online since 15th March '04
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