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  Citation statistics : Table of Contents
   1993| July-August  | Volume 59 | Issue 4  
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Proteus syndrome
Renu George, Mary Jacob
July-August 1993, 59(4):213-215
A case of proteus syndrome in a 20 year old male is repoted. Hemihypertrophy, asymmetric megalodactyly, linear epidermal naevus, naevus flammeus, angiokeratoma, lymphangioma circumscriptum, thickening of the palms and soles, scoliosis and varicose veins were present. There are only few reports of these cases in adults. The syndrome has not been reported from India.
  3 4,000 0
Epidermodysplasia verruciformis
ML Khatri, M Shafi
July-August 1993, 59(4):207-209
A Libyan male child aged 10 years having coeliac disease and moderately retarded growth developed epidermodysplasia verruciformis (EV) since the age of 4 years and later (8 years age) developed a lesion of porokeratosis of Mibelli on the cheek. Such an association has not been reported earlier.
  1 3,678 0
Oral colchicine in chronic plaque psoriasis
Prasanta Bassak, Animesh Chatterjee
July-August 1993, 59(4):168-171
Colchicine is well known for its antimitotic and anti-inflammatory effects. This study was designed to evaluate the role of oral colchicine in chronic plaque psoriasis. Fifty adults with chronic plaque psoriasis were randomly allocated into 2 groups of 25 patients each. Group A received oral colchicine 2 mg/day in 2 divided doses, while Group B patients were given placebo tablets. Patients were evaluated every week and the final result compiled after 8 weeks. 90% patients in Group A had gastrointestinal intolerance necessitating a reduction in dose of colchicine to 1 mg/day. After 8 weeks the lesions improved significantly in Group - A patients, compared to Group B (t=2.815, p<0.01). Apart from gastrointestinal intolerance and nephrotic syndrome, no other significant side effects were encountered. It may be worthwhile trying this drug in chronic plaque psoriasis recalcitrant to conventional topical treatment.
  1 7,367 0
Reiter's syndrome
P Madavamurthy, VS Babu Hanish
July-August 1993, 59(4):197-200
A 22-year-old mason presented with symmetrical polyarthritis of 2 years duration. He had a clandestine exposure 4 months before the start of the disease which resulted in a genital ulcer and urethritis. He had typical lesions of keratoderma blenorrhagica and inflammatory eye disease, positive rheumatoid factor and typical radiological features of rheumatoid arthiritis. The rare association of rheumatoid like arthritis and Reiter's syndrome is discussed.
  - 7,326 0
Hair casts
DM Thappa, Vijay Kumar, RC Sharma, S Lal
July-August 1993, 59(4):201-202
A case of hair casts in a 3-year-old girl is reported for its rarity and diagnostic dilemma.
  - 5,998 0
Darier's disease and depigmented macules
SN Tolat, S Agarwal, MA Borkar, SN Ghosh
July-August 1993, 59(4):203-206
A case of Darier's disease with depigmented macules; an extremely rare feature of the disease is reported. A familial occurrence of these lesions is highlighted. The probable pathogenesis and some unusual characteristics of these leukodermic macules is discussed.
  - 3,513 0
Linear porokeratosis of mibelli
MV Shenoy, K Venkateswaran Sri, BSN Reddy, Garg
July-August 1993, 59(4):210-212
An unusual case of linear porokeratosis manifesting unilaterally in a 25 year old male patient is reported for rarity and clinical interest.
  - 2,978 0
Linear lichen planus follicularis
Sandipan Dhar, Surrinder Kaur
July-August 1993, 59(4):216-217
A case of lichen planus follicularis with linear distribution is reported. There was no involvement of mucous membranes, scalp and nails.
  - 2,572 0
Familial incidence of pseudopelade of brocq
DK Sharma, SS Pandey
July-August 1993, 59(4):218-219
Pseudopelade of Brocq is an asymptomatic, beginning insidiously with small, white, depressed, bald spots, devoid of normal hair that mark the borders of some of the earlier lesions with atrophy and minimal perifollicular erythema, if at all. We report here a family of 3 members (2 brothers and 1 sister) with similar findings of cicatricial alopecia for more than 10 years duration but without any cause which may lead to scarring and loss of hair of primary type of pseudopelade. To the best of our knowledge no familial incidence of pseudopelade has been reported any where in the literature so far.
  - 4,253 0
Treatment of the so-called incurable skin diseases
JS Pasricha
July-August 1993, 59(4):159-167
  - 13,850 0
Biofeedback assisted relaxation (bar) in management of hyperhidrosis : A preliminary study
Gurmukh Singh, Gurcharan Singh
July-August 1993, 59(4):187-189
Ten adult male patients suffering from hyperhidrosis were managed with biofeedback assisted relaxation (BAR) regimen using skin conductivity. Six of them showed significant improvement, 2 showed minimal to moderate improvement, whereas no improvement was observed in the remaining 2 cases. Mean values of skin conductivity showed a range of 1.29 to 6.79 mho units before biofeedback session with reduction in these values to the range of 0.53 to 1.64 mho units after therapy in 6 patients showing good response. The grades of clinical improvement correlated well with corresponding reduction in skin conductivity in all the cases.
  - 4,959 0
Cutaneous sarcoidosis
RS Mishra, C Indira, U Saxena, A Mukherjee
July-August 1993, 59(4):190-193
Two cases of sarcoidosis with cutaneous lesions as presenting complaints are reported. Clinicians should have a high index of suspicion for sarcoidosis since it mimics other granulomatous skin conditions.
  - 4,787 0
Intralesional interferon alpha - 2b in genital warts : A preliminary study
RK Pandhi, Asit Mittal, K Lalit Gupta
July-August 1993, 59(4):194-196
Currently available therapy for condyloma acuminata (genital warts) is not consistently effective. Interferon (IFN) has both antiproliferatve and antiviral properties and has been used to treat genital warts with varying degree of success. We conducted an open study on 6 male patients with genital warts. A single wart of comparable area from each patient was injected with 2 106 IU of IFN alpha-2b, 3 times weekly for 3 weeks. The response to treatment was assessed during the therapy and at 1, 5 and 9 weeks after the completion of treatment. Two of the injected lesions showed complete regression and in 2, there was a moderate reduction in size but not a complete regression. In 2 patients there was appearance of new lesions while still on therapy and only a slight reduction tn the size of injected lesions. All patients tolerated the therapy well and in none treatment had to be discontinued due to adverse reactions. The preliminary trial suggests that intralesional IFN is not a superior alternate to the currently available modalities of treatment in genital warts. High cost of the therapy is another limiting factor.
  - 5,169 0
Post kala-azar dermal leishmaniasisa clinico-pathologic study
SM Sinha, G Gupta, RN Ghosh, U Ganguly, A Gupta Das
July-August 1993, 59(4):172-175
Post kala-azar dermal leishmaniasis (PKDL), a rare cutaneous lesion is now occurring with increasing frequency in endemic zones in India. Analysis of 20 cases of PKDL revealed previous history of kala-azar in all cases. Types of skin lesions were : hypopigmented macular (75%), erythematous macular (15%) and nodular (10%). Lesions were present mostly in face (64%). Amastigotes of L. donovani were present in 60% of dermal scraping smears and 50% cases on histopathologic examination. Histopathologically 80% showed non-specific mononuclear infiltration, including all the hypopigmented lesions. Amastigotes were detected in 37.5% of these cases. Non-specific compact granuloma was observed in 20% cases including 2 cases each of erythematous and nodular types. Parasites were detected in all these cases.
  - 3,661 0
Basophil leucocyte response in leprosy with lepromin-A
RP Okhandiar, HS Sharma
July-August 1993, 59(4):176-183
Study of 'Basophil Leucocyte Response' in two polar groups of leprosy patients (tuberculoid and lepromatous) was undertaken employing Lepromin-A (Armadillo) by the method of Open Window Technique of Rebuck. Significant infiltration of Basophils at the test side is demonstrated both at 48 hours and at 72 hours in lepromatous leprosy as compared to the control groups i.e., in placebo and tuberculin positive healthy volunteers as well as against tuberculoid leprosy group (p value being less than 0.05 and 0.001). The basophils also go into degeneration and degranulation at 72 hours. . The role of basophils in the different types of allergic reactions is discussed in context of above finding. The possible effect of high infiltration of basophils in lepromatous leprosy with its subsequent release of histamine and other factors by degranulation, and its possible role in immuno-regulation through specialised suppressor cells is postulated in the light of available data.
  - 4,421 0
Influence of liposomal drug entrapment on the performance of corticosteroid creams
GU Rao, RSR Murthy, YS Marfatia, Rajesh Shankar
July-August 1993, 59(4):184-186
Skin blanching and clinical efficacy of a liposomally entrapped triamcinolone acetonide (TRMA) cream was compared with that of the conventional TRMA cream in healthy human volunteers and eczema patients respectively. Both the creams showed equal efficacy in eczema patients. A significant reduction in the skin blanching response with the liposomal TRMA cream as compared to the conventional TRMA cream suggests a decrease in the systemic absorption of the corticosteroid with the former.
  - 3,364 0
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