Oral dapsone 200 mg daily for 16 weeks was tried on 52 adult patients, of whom 33 patients (males 17, femals 16) completed the study. No other topical or systemic medication was permitted. All the patients tolerated the drug very well. In 22 (66.5%) patients there was complete healing with hyperpigmentaiion after 16 weeks of therapy. In 7 (21.5%) patients partial respone was seen. There were 4 (12%) treatment failures. In patients with hiucosal lesions, the response started early and was seen more often (80.0%) No relapse was seen in any of the patients followed-up for a preiod of one year.

[ABSTRACT]   Full text not available    [CITATIONS]

A 6 year old Libyan boy had diffuse erythema at birth and later developed pruritic, maculo-papular, papular, circinat c, double-edge, scaly lesions, suggestive of ichthyosis linearis circumflexa (ILC).Hisscalp hair were brittle and sparse with partial patchy alopecia, showing change of trichorrhexis invaginata, these -associations being characteristic of Netherton's syndrome. The boy had slightly stunted growth; a feature which has not been recorded in previously reported cases.

[ABSTRACT]   Full text not available   

Fifty cases of sweat gland tumours seen during a. period of 27 years, accounted for 54.34% of skin appendages tumours. There were 47 sweat glands, tumours and 3 malignant, seen in the 21- 40 years age group. M : F ratio was 1:1 Histopathol4caUy, there were 13 cases of eccrine, acrospiroma, 11 cases each of syringocystadenovaa papiuiferum and chondroid syringoma, 5 cases of eccrine, spiradenoma, 3 cases of dermal cylindrom and 2 cases each of hidradenoma papilliferum and eccrine pogrom. Three cases of malignant sweat gland tumours included 2 cases of sweat gland-carcinoma and 1 case of primary mucmous carcinomas of skin.

[ABSTRACT]   Full text not available   

Nasal filter is a simple device consisting of a net mounted in a frame made to fit inside the nostrils. These filters thus are not visible from outside. If a person uses the nasal filters the .u particulate material from the air that the person breathes gets removed and in case the person is allergic to an inhalant antigen, he stops having the allergic symptoms. We tried nasal filters on two females patients aged 32 and 7 years respectively, having topics dermatitis the age of I year, caused by an inhalant (indicated by seasonal aggravations, and spontaneous recovery during brief visits to other towns). Unrig a follow-up of 2 1/2 and 2 years respectively, both the patients experienced almost 80-90% relief from the dermatitis and required only animal treatment.

[ABSTRACT]   Full text not available   

A 23-year-old male presented with with-defined orange-brown patches on the lower legs of 6 months duration. The lesions were I and had been largely asymptomatic. The clinical picture and histopathology were consistent with lichen aureus.

[ABSTRACT]   Full text not available   

Autopsies were performed on two cases of harlequin ichthyosis, with typcal clinical and microscopic features. Both died of lung , compromise. Neutral fat in the stratum could be demonstrated in one. This feature has been documented in only one previous case report. Routine laboratory investigations were within normal limits.

[ABSTRACT]   Full text not available   

Out of 3000 consecutive subjects surveyed for the typical lesion of transverse nasal groove, 180 were found to have the characteristic lesions. In LU patients, the floor of the groove was studded with patulous hair follicles, greasy sale and black comedones. The age of the patients varied from 16 to 45 years, the majority belonged to the 20 to 30 age group. Family occurrence of the groove was noted 'in only 7.Seboffhoeic dermatitis, pityriasis versicolor and acne vulgaris were the commonly associated diseases.

[ABSTRACT]   Full text not available   

Full text not available   

A 4-year-old girl had linear verrucous lesions restricted to the axilla and groin on the right side of the body. The lesion was itchy and had repeated episodes of infection. Histopathology was characteristic. Response to local betamethasone dipropionate was good.

[ABSTRACT]   Full text not available   

A 65 year old male had recurrent primary mucinous carcinoma of skin arising in the upper one third of the left forearm. It was characterised by the presence of a large area , of mucin with the tumour cells present in sheets and arranged in duct-like structures. Primary mucinous carcinoma is characterised by a very low incidence of metastases. The mucinous material seen in the primary mucinous carcinoma is non - reactive to alcian blue and aldehyde fuchsin at a very low pH (0.4).

[ABSTRACT]   Full text not available   

Our regime for the treatment of pemphigus consists of 100mg dexamethasone dissolved in 5% glucose given by a slow intravenous drip over 1-2 hours and repeated on 3 consecutive days. On the first day, 500 mg cyclophosphamide is also given in the same drip. Such dexamethasone cyclophosphamide pulses (DCP) are repeated once a month. In between the (DCP), the patient is given only 50 mg cyclophosphamide daily orally. During the first few methods of starting this treatment, most patients continue to get relapses of pemphigus lesions in between the DCP (phase I). After a variable period however, almost all patients stop having such relapses, but we continue to give once monthly DCP for atleast 6 months (phase II), After which the DCP is stopped and the patient continues to take 50 mg cyclophosphamide daily orally for a further period of one year (phase III). At the end of thos phase all treatment is stopped and the patients followed-up for any relapse (phase IV). Follow up of the first 100 patients, pemphigus vulgaris (92), pemphigus follaccus (6) and pemphigus erythematosus (2), has

[ABSTRACT]   Full text not available    [CITATIONS]

A 24 yew old patient having pemphigus for the last 1 year delivered a female baby after 36 weeks of gestation. The baby had pemphigus like lesions on the skin and a single ulcer on the hard palate. The serum antibody titres of intercellular antibodies in the mother and the baby at the time of delivery were 1:80 and 1: 40 respectively. 1 The lesions in the baby healed completely by the 9th day after birth, without any specific treatment. Three months later the antibody titre in the mother was 1: 40, while in test became negative The baby the baby, the has since shown no recurrence of the lesions.

[ABSTRACT]   Full text not available   

A 33 old I female developed methaemoglobinemia manifesting as cyanosis fatigue, malaise and headache 3 weeks after being put on l00 mg of dapsone daily for borderline - tuberculoid leprosy. Similar manifestations develope4 in a 15 year old boy 9 days after he, was put on 50 mg of dapsone daily for suspected indeterminate leprosy. withdrawal of dapsone resulted in reversal of methaemoglobinemia.

[ABSTRACT]   Full text not available   

A case of mycosis fungoides had unusual features such as non- pruritic nodule-ulcerative lesions following a febrile, episode, appearance of many lesions in subsequent episodes in the margins of scars of previous lesions, along with a cyclic course. Higtopathology of the skin and lymph node showed a typical picture, of mycosis fungoides.

[ABSTRACT]   Full text not available   

Full text not available   

Full text not available   

Full text not available    [CITATIONS]

Full text not available