A case of Primary Raynaud's disease is being presented as an interesting clinical oddity in a woman of 40 years of age. The woman was emotionally unstable and the disease was precipitated by exposure to cold. A follow up of two weeks showed regressive changes. This emphasizes the role of ecology in skin diseases and the need for regional dermatology.

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A case of juvenile bullous pemphigoid is described and its diagnostic criteria are discussed.

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Lipoid proteinosis is a rare disorder, about 50 cases having been reported until 1957. This is possibly the first report from India. A Hindu male, aged 23 years presented with skin lesions since he was 10 months of age, and hoarseness of voice since the age of 4. The lesions appear in crops, each attack involving only a few areas of the skin. During the course of 22years, the lesions have appeared on all parts of the body surface. The lesions start as a small solid swelling (papule) which evolves into a bleb (Vesicle) within the course of 4-5 days, these develop into lesions containing pus-like fluid which burst leaning behind ulcers which heal in 10 to 15 days, resulting in varioliform scars. The scars were more prominent on the face. Exacerbation of lesions were noticed during extremes of weather in the summer and winter and itching occurs only occasionally.

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Three members of a family with Xeroderma pigmentosa are reported here. They all were above the age of 20 years with no evidence of malignancy.

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Our analysis clearly indicated that majority of our respondents had a history of prolonged and frequent sexual indulgence irrespective of their marital status. The cultural norm in our society prohibits any kind of sexual indulgence except marital and the fact that 53% of our respondents were married established that either of the spouses of this group was maintaining extra marital relations and, carried the infection, thus deviated from traditional norm. This was, therefore, either formulating its own norms which were contradictory to the established norms of our society or revolutionalising the existing norms governing sexual behaviour, which may be manifested in the modern value system.

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In summary, toxic epidermal necrolysis as a distinct clinical entity which shows skin with large areas of black discolouration and peeling and mucosa with severe ulceration. Histologically epidermal necrosis and haemorrhage are its characteristic features. This entity is probably an extreme variety of Steven Johnson-Syndrome. Steroid therapy is found to be useful in this condition.

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