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2003| September-October | Volume 69 | Issue 5
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EDITORIAL
Dexamethasone pulse therapy in dermatology
M Ramam
September-October 2003, 69(5):319-322
PMID
:17642928
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STUDIES
Pulse therapy and its modifications in pemphigus: A six year study
PN Rao, TS Lakshmi
September-October 2003, 69(5):329-333
PMID
:17642930
Background: Dexamethasone-cyclophosphamide pulse (DCP) therapy for the pemphigus group of disorders is being widely used in India after its introduction in 1986. However, there are certain limitations to its application due to the serious side effects of cyclophosphamide. Methods: Between 1995 and 2001, we treated 41 patients of pemphigus with modified pulse therapy. These modifications included certain changes in the DCP therapy protocol and substitution of cyclophosphamide with either azathioprine or methotrexate in a few patients. Results: We observed a good response to pulse therapy in all 34 patients who took treatment regularly. Conclusions: We found the modifications to the original DCP therapy protocol to be very effective and useful.
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VIEW POINT
Pulse therapy as a cure for autoimmune diseases
JS Pasricha
September-October 2003, 69(5):323-328
PMID
:17642929
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STUDIES
Treatment of pemphigus with intravenous pulse cyclophosphamide
NR Gokhale, PM Mahajan, RR Sule, VA Belgaumkar, SM Jain
September-October 2003, 69(5):334-337
PMID
:17642931
Background: The complications associated with the use of systemic corticosteroid therapy have prompted a search for alternative agents. However, these agents are themselves associated with increased risk of myelosuppression or malignancy. Methods: The present study included twenty patients with recalcitrant pemphigus or steroid induced side effects who were treated with intravenous cyclophosphamide pulse therapy. Results: Out of 18 patients who completed the study, 14 showed good to excellent response. Thirteen were able to decrease their daily dose of steroid to 5-10 mg prednisolone while one could stop steroids altogether. Most patients did not experience serious side effects. Discussion: Thus intravenous pulse cyclophosphamide is a promising form of therapy in pemphigus either recalcitrant or intolerant to steroid therapy. The decreased total cumulative dose of cyclophosphamide with intravenous therapy as compared to oral therapy may reduce the incidence of secondary malignancy.
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DISPENSING PEARL
Castellani’s paint
MK Shah
September-October 2003, 69(5):357-358
PMID
:17642940
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CASE REPORT
Inflammatory cutaneous metastasis as a presenting feature of bronchogenic carcinoma
AC Inamadar, A Palit, SB Athanikar, VV Sampagavi, NS Deshmukh
September-October 2003, 69(5):347-349
PMID
:17642936
An elderly man with a long history of smoking presented with an excruciatingly painful mass of short duration on the left side of the neck, without any systemic complaint. Clinical and radiological examination revealed left upper lobe consolidation which was proved to be secondary to bronchogenic carcinoma. Histopathological findings from a skin biopsy from the neck mass were consistent with inflammatory cutaneous metastasis. Interestingly, this was the presenting feature of the underlying malignancy in this patient. This pattern of cutaneous metastasis has rarely been reported in association with bronchogenic carcinoma.
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RESIDENTS«SQ» PAGE
Silent neuropathy: Detection and monitoring using Semmes-Weinstein monofilaments
A Santhanam
September-October 2003, 69(5):350-352
PMID
:17642937
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CASE REPORT
Chilblain lupus erythematosus mimicking acrofacial vitiligo
BK Khaitan, A Sood, R Mittal, YL Singh, MK Singh
September-October 2003, 69(5):340-342
PMID
:17642933
Chilblain lupus erythematosus with depigmentation is a rare presentation of lupus erythematosus that may simulate vitiligo. A 52-year-old lady with such a manifestaiton is being reported.
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Juvenile dermatomyositis associated with lipodystrophy
NT Irene, B Parveen, OH Hema, V Rajagopalan
September-October 2003, 69(5):343-344
PMID
:17642934
Lipodystrophy and associated metabolic abnormalities are being increasingly recognized as complications of juvenile dermatomyositis. We report one such case.
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Multiple cystic swellings of the scalp: A complication of intralesional steroid therapy
AK Lahiry
September-October 2003, 69(5):345-346
PMID
:17642935
An unusual complication, multiple cystic swelling of scalp, arising due to intralesional steroid injections given for alopecia areata using a Dermajet is being reported.
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QUIZ
A solitary painful nodule
KN Shivaswamy, DM Thappa, S Jayanthi
September-October 2003, 69(5):359-360
PMID
:17642941
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LETTER TO EDITOR
Clinico-mycological evaluation of onychomycosis at Bangalore and Jorhat
V Ramesh
September-October 2003, 69(5):361-362
PMID
:17642942
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Response by the authors
S Grover
September-October 2003, 69(5):362-363
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Grapefruit juice vs. grape juice
MJ Cyriac
September-October 2003, 69(5):363-363
PMID
:17642943
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Response by the authors
S Prabhu, SD Shenoi
September-October 2003, 69(5):363-364
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BOOK REVIEW
Current literature: Dermatology 2001–2002
KK Raja Babu
September-October 2003, 69(5):365-365
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MEDICOLEGAL WINDOW
Prescribing steroids and cytotoxic agents
SP Sirur
September-October 2003, 69(5):353-354
PMID
:17642938
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TABLES
Safety of dermatologic agents in pregnancy
S Pande, V Kharkar
September-October 2003, 69(5):355-356
PMID
:17642939
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CASE REPORT
Pachyonychia congenita-like nail changes treated successfully with a combination of vitamins A and E: A case report
BB Mahajan, A Pall, G Garg, R RR Gupta
September-October 2003, 69(5):338-339
PMID
:17642932
A 20-year-old man presented with thickening, subungual hyperkeratosis and discoloration of all the nails of both hands and both great toes since birth. No other ectodermal abnormalities were found. Treatment with vitamins A and E in high doses along with a moisturizing ointment topically for one year resulted in complete resolution of all nail abnormalities.
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