Efficacy of topical tretinoin was assessed in 30 cases of idiopathic acanthosis nigricans which were recalcitrant to conventional modalities of treatment. Topical tretinoin once at night application was found to be very effective both clinically and histologically.

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A rare case of hereditary motor and sensory neuropathy in a 45 year old man with glove and stocking hypoaesthesia, bilateral clawing, foot drop and thickening of the peripheral nerves mimicking Hansen's disease is reported.

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A rare case of nodular colloid degeneration is reported which presented clinically as plaques studded with soft yellow papules simulating adult colloid milia superimposed only on herpes zoster scars of right side of the face.

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A 50-year old man with a history of multiple contacts with commercial sex workers and two episodes of blood transfusions in Bombay, presented with giant mollusca contagiosa, Kaposi's sarcomas and refractory pulmonary tuberculosis. Patient was confirmed to be infected with HIV by ELISA and Western blot method.

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Three cases (two male, one female) of botryomycosis are reported. All were adults and had no predisposing factors or immunosuppression. Staphylococcus, Pesudomonas and E coli were grown on bacterial culture. Patients were treated with antibiotics based on the sensitivity pattern with fairly good response. No systemic involvement was present in any case.

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Two female patients suffering from rheumatoid arthritis were put on chloroquine 250 mg bid. After a period of 4 weeks, both of them developed photosensitive dermatitis. Following withdrawal of chloroqunie, both of them showed improvement in dermatitis gradually over a period of 3-4 months.

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A rare case of multiple cutaneous mastocytoma presenting at birth with multiple skin coloured to hyperpigmented papulonodules and plaques all over the body is being reported.

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Disseminated superficial actinic porokeratosis in a 40-year-old man is described. The diagnosis was confirmed by histopathology in which the classical cornoid lamella was seen.

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A 15-year-old male, born of non-consanguineous marriage started developing thickening of skin of sole of the both feet at the age of 7 which progressed to involve whole of both feet by 11th year. Patient later developed painful autoamputation of little toes of both feet due to pseudoainhum. Involvement of the palms was limited to a localised area over palmar aspect of right middle finger and was non-progressive. No other family member was affected. This may represent a variant of Vohwinkel's syndrome or the rarer form of acral keratoderma.

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A very rare case of osteoma cutis is being presented here. Cutaneous involvement was very extensive in this case.

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A 26-year-old man, a parenteral pentazocine abuser for past 10 years, presented with woody induration on the areas of injections and multiple, punched-out, deep, painless ulcers surrounded by hyperpigmented halo. This appears to be the first report from India on skin manifestations of pentazocine abuse.

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A 2-month-old infant presented with the skin nodules of 1½ months duration. Routine investigation and bone marrow examination showed the presence of myeloblastic Ieukaemia-M₄ type, FAB classification.

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A study was conducted to assess the response of reactions in leprosy to pentoxifylline therapy. Ten cases were studied; 8 cases had type 2 reaction and 2 cases had type 1 reaction. Pentoxifylline was given orally 400 mg three times daily. In patients with type 2 reaction, good response was observed within one week. There was near complete regression of ENL lesions within one month. Cases with type 1 reaction did not respond to pentoxifylline.

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A 40-year-old man presented with clinical and histopathological features of accessory tragi. His father and 3 sons and 1 daughter had similar lesions. In view of this vertical transmission through 3 successive generations involving both the sexes, an autosomal dominant mode of inheritance is suggested.

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Two female patients aged 25 and 12 years suffering from malaria presented with picture of Stevens Johnson syndrome. Each of them had received daily doses of chloroquine phosphate by intramuscular injection for 3 days. They progressed to toxic epidermal necrolysis and could not be saved despite best of efforts.

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Cutaneous sarcoidosis in a middle aged lady is reported. Though sarcoidosis is rare in our country, an awarenesss about this condition is required to prevent misdiagnosis.

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Spiradenoma is a solitary, deep seated nodule occurring on the ventral surface of the body, especially over the upper half. We are describing a case of spiradenoma with zosteriform arrangement.

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A 40-year-old male with painful neurilemmoma is reported. Clinically the patient had multiple painful nodular lesions over the right lower limb. Histopathology confirmed the diagnosis of neurilemmoma. The probable mechanism for painful nodular presentation is highlighted.

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