Fifty cases with chronic idiopathic urticaria of more than 3 months duration were selected and divided into two groups. Group 'A' was given 10 mg loratadine once daily, while group 'B' was given pheniramine maleate 25 mg, twice daily for one month. All patients were followed for one month more. 48% excellent response was observed in group 'A' while 16% excellent response was observed in group 'B'. Good response was observed in 24% of patients in group 'A', while in group 'B' 16% of patients had good response. No side effects were observed in loratadine group, while drowsiness was observed in pheniramine group

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a 40-year-old male patient presented with cutaneous vasculitis affecting both lower legs without any evidence of systemic involvement and a bilateral sensory neuropathy affecting both lateral popliteal nerves. Treatment with oral prednisolone resulted in healing of the cutaneous lesions but the sensory loss persisted.

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A two-and-half month-old female infant with cavernous haemangioma, agenesis and syndactyly of toes, microophthalmia and microcornea is reported.

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43 patients were taken up for the study, all of whom were asymptomatic and presented with bluish black pigmentation. 23 patients presented with pigmentation which was proximal and distal to the bony prominences, all of whom gave a history of using nylon scrubbers during bathing. 20 patients gave no history of friction and the pigmentation was present on the extensor forearms, shins and upper back. Histopathological examination confirmed amyloid deposits.

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A 47 year old hypertensive and diabetic male patient suffering from eosinophilic cellulitis (Wells syndrome) is being reported. The patient responded very well to oral griseofulvin at the time of first presentation and subsequent three recurrences in a period of three years.

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Eleven case of disseminated herpes zoster (DHZ) who were hospitalised in the Dermatovenereology ward from January 1992 to April 1995 were selected for this study. All had classical herpes zoster (HZ) but within another 2 to 15 days had developed aberrant vesicles on the trunk, limbs and face. None of them had serious associated immunosuppressive disorder or malignancy. However, 3 cases had diabetes mellitus, 2 were receiving prednisolone 15 mg daily for the last few days, 2 had anaemia and deficiencies and 1 had a urinary tract infection. Only one patient needed oral acyclovir therapy. All were cured without any sequelae.

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Proteus syndrome is a hamartomatous disorder characterised by focal overgrowths that can involve any structure of the body. An eleven-year-old girl with Proteus syndrome has been described with clitoromegaly.

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A case of follicular mucinosis is being reported. Clinically, the patient had discrete follicular and non-follicular papules on the face, neck and arms. Light microscopy confirmed the follicular outer root sheath, and sebaceous gland epithelial degenerative changes. The infiltrating inflammatory cells were morphologically benign. The response to oral dapsone therapy is highlighted.

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Renal functional impairment is known to occur in lepsory, specially of multibacillary type. Pedal oedema was seen in 30% patients. Urine analysis showed proteinurea in 3.33%. epithelial casts in 13.33% and microscopic haematuria in 6.66%. A raised 24 hours urinary protein excretion was seen in 53.33%, 60% had a low 24 hours creatinine clearance rate. Abnormal serum creatinine was found in 16.66%, raised serum urea values were seen in 6.66% cases

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A 50-year-old female had vitiligo and alopecia universalis. She developed pemphigus vulgaris with a history of recent increase in the size of the vitiligo patch. Corticosteroid therapy controlled the pemphigus vulgaris, halted the extension of the vitiligo lesion and promoted regrowth of hair. The coexistence of these three diseases in the same patient lends credence to the contention that autoimmunity plays a role in the pathogenesis of these diseases.

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A case of recessive dystrophic epidermolysis bullosa in a 17-year-old boy is described. The diagnosis was based on clinical and histophathological findings. The patient is being treated with 200-300 mg of phenytoin sodium per day maintaining a blood level of 13-15 mg/litre and is under remission for 1 year.

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Herpes zoster occuring at two different sites in the same individual at the same time, involving more than two segments at each site has rarely been reported. We recently observed two such cases. The first patient was HIV-infected 10 year old haemophiliac who had zoster involving the distribution of the right C4, 5, 6 and left L 2, 3, 4 dermatomes and the second one was a 50 year old renal transplant recipient on immunosuppressive drugs who developed zoster at left C3, 4, 5 and left T 7, 8, 9.

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We have investigated 16 cases of cutaneous malignant melanomas and 34 cases of various types of neavi for formaldehyde-induced fluorescence. All cutaneous malignant melanomas (100%), but only two out of 34 naevi (5.88%) showed FIF positivity. The significance of this finding as a predictor of biological behaviour is discussed

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Out of total 2330 patients, 516 patients with STD i.e., 22.14%, were analysed during the period 1993 to 1994. Frequency of different STDs observed in order were herpes progenitalis (21.89%), syphilis (16.27%), chancroid (11.82%) and granuloma inguinale (7.55%), gonococcal urethritis and genital warts (3.87% each). L G V was found in 0.58% of cases, HIV infection in 3 cases only (0.56%). Other miscellaneous infections like candidiasis (13.75%), trichomoniasis (2.7%) and molluscum (2.14%) were responsible in 18% as a whole and nonspecific infection in 14%. Most of the patients were married, were from low socio-economic status and there was always a male preponderance with a peak age between 20 to 30 years.

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A case of urticaria pigmentosa mistaken for xanthoma disseminatum is presented.

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A case of incontinentia pigmenti, a rare genodermatosis, is being presented.

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A 60 year old female patient presented with disseminated tuberculosis. She had multicentric lupus vulgaris and her joints, bones, lymph nodes and lungs were also affected. Haematogenous dissemination was because of her poor health.

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A 35 year old female had multiple progressive painful, tender, soft, bluish compressible nodules with the feel of rubber nipples. There was no evidence of gastrointestinal haemangiomas or other systemic abnormalities. Histopathologically, cavernous haemangioma with prominent smooth muscle outline proved the clinical diagnosis of blue rubber bleb naevus. Only cutaneous lesions were seen in the patient.

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