Thirty nine girls between 12 and 31 years in age, having Premature grey hairs were, treated with calcium pantothenate 200 mg, Basiton Forte. (a vitamin B complex formulation), and/or vitamin E 200 mg a day orally, combined with grey hair evulsion which consists of pulling out all the grey hairs along with snipping the converted hairs at the grey black junction, and checking after 3-5 months, the numbers of hairs regrowing as grey hairs, new grey hairs, new converted hairs and the hairs missed during the previous check - ups. This study revealed that following evulsion of grey hairs, all such hairs do not regrow as grey hairs, the per cent rate of regrowth varied between nil and 88.23% during the first recheck, and almost similar results were obtained during further follow up. Out of 7 patients who have been followed up for almost 3 years, the total numbers of grey hairs had decreased from 109 to 15, 47 to 1, 35 to 7, and 242 to 7 in 4 cases, increased from 31 to 108 and 23 to 41 in 2 cases, and remained almost unchanged from 25 to 33 in the seventh case. This response is considered better than the effect of calcium panthothenate used without grey hair evulsion.

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Accidental observation of cure of premature greying in a patient who had lten on PUVASOL therapy for psoriasis made the author to try this form of therapy in 37 patients with premature greying. Majority (59.09%) of the patients were aged between 10 and 15 years. Complete repigmentation of the hairs was noted in 17 patients after treatment. Seven patients responded only partially, and in 8 there was no response at all.

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A 42-year-old female had myasthenia gravis secondary to thymoma. She developed lichen planus, which erupted simultaneously with the early signs and symptoms of myasthenia gravis. The association of thymoma and lichen planus m the present case seems to be causal rather than fortuitous.

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Irritant potential of 3 cacti, Opuntia dilenii, Rhispalis baccifera and Cereus Peruvians, and 4 succulents, Euphorbia royleana, Euphorbia antiquorum,Sansevieria zeyilanica and Agave sisalana was tested by rubbing their freshly exposed pulp 10 times on the forearm skin of 10 human voluntrees. Opuntia dilenii, Euphorbia antiquorum, Rhispalis baccifera and Agave sisalana produced transitory itching and burning or dermatitis in only one patient each, indicating that these plants are not highly irritant. Patch tests undertaken with the juice, pulp or other components of these plants as well as those of 5 lichens, Parmelia trichotera, Parmelia sulcata, Parmelia quercina, Parmelia furfuracea and Parmelia verrucifera, and 6 aquatic plants Nelumbo nucifera, Eichnornia crassipes, Trapa natans, Anabaena, Salvinia auriculata and Ceratophyllam demeusam in 10 cases each revealed positive reaction with Opuntia Dilenil, Rhispalis baccifera, Cereus Peruvians, Parmelia verrucifera, Nelumbo nucifera, Trapa natans, Salvinia auriculata and Ceratophyllum demeusum in one case each. Agava sisalana and Sensevieria zeylanica in 2 cases each. Euphorbia antiquorym, Parmelia trichotera ' Parmelia quercina, Parmelia furfuracea and Eichhornia crassipes in 3 cases each and Euphorbia royleana and Parmelia sulcata in 4 cases each.

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A clinical analysis of L50 patients having vitiligo revealed the incidence among new patients to be 1.25%. The male /female ratio was 1.3:1. Patients below the age of 30 years constituted 85%. Family history of vitiligo was available in 240/o. The different morphologic, Patterns consisted of vitiligo vulgaris (90 cases), vitiligo areata (22 cases), vitiligo acro-facialis (11 cases), vitiligo univers (11 cases , vitiligo mucoaae (9 cases),and vitiligo zosteriformis (7 cases). Association with diabetes meffitus (5 cases), alopecia areata (4 cases), Hashimoto's thyroiditis (1 case) and pemphigus vulgaris ( 1 case ) was observed.

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One percent minoxidil solution was used topically for the treatment of 10 patients having alopecia areata (4 each having alopecia universalis and totalis and 2 patients with extensive alopecia areata ). Significant hair growth did not occur even' after 3 months of therapy.

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A case of latent syphilis presented with unilateral cataract, which developed most probably as a complication of syphilitic cyclitis which he had during the secondary stage of the disease. Blood VDRL was reactive at 1: 32, but CSF was normal. Aqueous humor and the extracted lens material did not contain any Treponema palfidum.

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A 52 year old male who had been having - vitiligo for 20 years, developed alopecia universalis since 4 years and disseminated discoid IUPUS erythematosus since 2 years. The coexistence of these three diseases in the same patient lends credence to the contention that auto' unity may play a role in the pathogenesis of these diseases.

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A 10-year-old girl developed epidermal nevus, shortness of limb, scoliosis, hemiatrophy with history of multiple pathological fractures. Bone biopsy revealed fibrous dysplasia. This is an extremely rare combination of epidermal nevus with fibrous dysplasia.

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Twenty five cases of different types of pso6" who were resistant to conventional therapy, were treated with oral aromatic retinoid (Tigason). We observed complete and partial improvement in 4 patients, while 2 cases did not show any improvement Mild -to moderate side effects were noticed in 23 patients.

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Twenty patients having contact dermatitis on the forehead due to kum-kum were patch tested with the commercially available kum-kum,and also the turmeric powder used as such, as well as after alkalinisation potassium hydroxide to produce a reddish brown.colour. Patch tests were positive in all the patients with the commercial kum-kum, but not with the turmeric powder in either form.

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A patient had vitiligo for 10 years with development of new lesions for the last. Four months. Concomitant with the recent activation of vitiligo, he developed pemphigus vulgarism. Corticosteiroid therapy controlled pemphigus vulgaris, and also halted the development of new vitiligo lesions. Histopathologic study revealed inflammatory infiltrate at the dermo-epidermal junction along with basal cell layer dissolution suggesting atuoimmune, origin of vitiligo.

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A classical case of lipoid proteinosis in a 17 year old girl presenting with hoarseness of voice, thickened tongue, bullous lesions predominantly on pressure areas and varioliform scarring on the face and the extremities is reported. Her x-ray skull showed typical bean-shaped calcification in the limbic area. Histopathology revealed PAS stained amorphous deposits in the dermis and around the sweat glands.

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A year old male child developed progeria manifesting most of the typical changes described in progeria. The boy also had extensive sclerodermatous changes in the skin.

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A 9 year old female child developed creeping eruption on the neck which is an unusual site.

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A 3 1/2 year old male child with acute lymphatic leukemia developed pustular eruptions. The clinical course, histopathol6gical study and therapeutic response to dapsone suggested a diagnosis of subcomeal pustular dermatosis.

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Squamous cell carcinoma developing over a plaque of neurodermatitis is reported in an elderly male.

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