Clinically diagnosed and mycologically proved 54 cases of tinea capitis detected at skin out -patient Department of University Ropital, Banaras Hindu University. Varanasi, during May, 1979 to April 1980 were studied. Tinea capitis was an affliction of prepubertal male children of villages. 'Black dot' type was the commonest variety followed by 'kerion' type which was exclusively seen among rural children. Scaly gray patch type was confined to city children. No definite source of infection for 'black dot' type was detected. The source of infection in all the inflammatory type of tinea capitis was traceable. The lesions were always multiple. T. violaceum was the commonest etilogical fungus. It mostly caused 'black dot' type but inflammatory lesions were also due to them. T. mentagraphyte caused 'kerion' type only. T. tonsurans and T. verrucosum also contributed to inflammatory tinea capitis. T. rubrum caused only non- inflammatory type of lesions. M. nanum was isolated in 2 cases of non-infl.qmmatory tinea capitis. No defect in ceu-mediate,d immunity was detected in'black dot' lesions as well as in scaly type of tinea capitis by phytohaemoagglutinin intra-dermal tests.

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Strains of Neisseria gonorrhoeae isolated from smear-positive male patients suffering from acute gonococcal urethritis were studied. Their identity was confirmed on the basis of morphology, oxidase reaction, fermentation of glucose only and failure to grow on nutrient agar. A total of 100 such isolates were, tested for beta-lactamase production by use of nitrocefin. None of these isolates were beta-lactamase producers. A who reference beta lactamase positive strain (No. 5731) was the control.

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19.6% and 3.0% isolates of N. gonorrhoeae were found respectively to be resistant to penicillin and co-trimoxazole during the period of this study. Penicillin (procaine penicillin, 1.5 mega units + crystalline penicillin, 1.5 mega units) given intra- muscularly as a single injection was found to be slightly more effective compared to cotrimoxazole (Septran) 4 tablets twice daily X 2 days. Co-trimoxazole is a good alternative drug to penicillin and can be use in patients who are either allergic to penicillin or where penicillin has failed to cure the gonococcal infection. Cotrimoxazole was quite effective in the treatment of gonococc subacute prostatis.

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A quantitative assay -of faecal prophyrins was undertaken by spectrophotometric method of Rimington in forty women, of child-bearing age Thirty women- On Oral contraceptives constituted the study group and ten on other methods of contrace on served as controls. In the study group the mean and standard deviation of faecal CoProporphyrins were 6.747 and 7.215 respectively and of faecal protoporphyrin levels 13.549 and 9.509 respectively.It was observed that 10 per cent of the women on oral contraceptives had raised faecal copro and protoporphyrins, which however, was statistically not significant.

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An unusual association of discoid lupus erythematosis and adeno- carcinoma of palate is being described. A relationship between the two, however, could not be established.

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Two patients with multiple, metastatic nodules in the skin are described. One of them was a 52-year old man who had midtarsal amputation of his right foot for 'melanoma' of the s6le. The other was a female patient who presented with multiple cutaneous nodules, which on histology proved to be undifferentiated carcinoma cell deposits. The primary site of carcinoma was not detected in this case. Both patients developed leukoderma around the metastatic nodules. Peritumoural leukoderma was followed by the spontaneous regression of two metastatic nodules in the latter case. The possible mechanism is discussed with a review of the literature.

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Fifty men suffering from uncomplicated urethritis were treated either with 1, 280 mg of (TMP) and 6,400 mg of (SDMO) (Supristol 16 tablets) eually divided doses taken at a 12 or with a single dose of 3.5 gm of with 1 gm of probenecid . The cure rate in TMP-SDMO regimen was 79% while that in AMP-PBD regimen was 95.7%. Sensitivity of the organism to penicillin, ampicillin and TMP-SDMO. Toxic effects of the drugs were studied.

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A study of 50 patients with lichen simplex chronicus and 50 patients with scabies as control shows a significant family history of atopic disorders in patients with lichen simplex chronicus.

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Urinary porphyrins were measured in thirty women on oral contraceptives who constituted the study group and in ten women using conventional methods of contraception who constituted the control group. The difference of theme an so furinary copro and uroporphyrin in the two groups.was found to be statistically insignificant. Further, the effect of duration of treatment of females using oral contraceptives was also studied. The difference of means was not significant a the cases oral contraceptives for a period Of less than six months and cases using the same for more than six months.

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Clinical features of 70 cases of pitted keratolysis are described. Bacterial and mycological cultures were done in 20 cases. Sixteen of these (80%) and 7 out of 10 (70%) controls yielded corynebacterium species in culture. The significance of this finding in relation to the aetiology of pitted keratatolysis is discussed. An attempt to reproduce the lesions artificially in 5 healthy volunteers did not succeed.

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A case of reactive perforating couagenosis occurring in a 23-year-old lady born of consangiunous parents is reported. No other member of the family was affected. Lesions had started appearing at the age of 12 years . with remissions and exacerbations. The lesions were mainly distributed over the exposed parts of the body. Histopathology was consistent with the clinical diagnosis. The paucity of reports regarding this entity has prompted the author to report this case.

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Bullous pemphigoid developing at the same tune in identical twin sisters with diabetes mellitus is reported.

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