Twenty-five patients with scabies were studied for the evaluation of metronidazole as an oral therapeutic agent. These patients were given 400 mg of metronidazole three times daily for 8 days. Good to excellent results were observed in 6 (27.27%) patients, 8 (36.36%) patients showed a fair response and no response was observed in 8 patients (36.36%). The significance of these results are discussed.

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A typical case of pachyonychia congenita in a female is presented. Of the sixty cases of pachyonychia congenita reported in the literature, only one case is a female. Cases have been seen in families upto five generations. In our case five family members belonging to two generations manifested the disease. The hyperkeratotic plantar lesions were painful and incapacitating to the patients. With combined dermabrasion and topical retinoic acid the patients were made rapidly ambulatory. This new modality of treatment seemed gratifying in that the symptomatic relief to the patient was excellent.

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A case of tuberculosis affecting the skin and nasal septum and 10 years later involving the hard palate causing perforation is reported.

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Out of 23808, sera screened for syphilis by VDRL tests from antenatal cases, 1155 were reactive, giving an incidence of 4.85%. This has been compared with the incidence of reactive ,sera for syphilis in antenatal cases by various other workers. We have compared 300 sera with various reactivity by VDRL test with KVT and found only 2 false positive and 57 inconclusive, thereby indicating need to have specific tests. There was-good correlation between VDRL and KVT, but VDRL was more sensitive, whereas KVT was more specific. Various serological tests for screening syphilis have been discussed in brief and ultimately concluded that VDRL is the best screening test.

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Primary malignant melanoma of oral cavity is very rare. A case of oral melanoma who died due to metastasis a year after the excision of the primary lesion is reported along with a brief review of the literature.

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A retrospective analysis of 26 cases of delusory parasitosis is recorded.

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Results of treatment of 50 psoriatic patients with psoralen and ultraviolet radiation are reported. A detailed analysis of the data is also given. None of the patients was resistant to treatment. Complete clearing of all lesions occurred in 22% of the patients in 16 days, in 96% of the patients in 40 days and in 100% of the patients in 45 days. It is concluded that photo chemotherapy with psoralen and ultraviolet radiation from conventional uv radiation therapy lamps is a safe and effective treatment for patients with psoriasis in this country.

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Histomorphological study on 48 cases of vitiligo was carried out. The main finding in our serial section study was the demonstration of mononuclear hugging at the borders of the progressive vitiliginous macules with normally pigmented skin. The mononuclear cells were almost exclusively small lymphocytes. They were found at the dermoepidermal junction and also intra-epiderrnally. A selective abscence of melanocytes and melanin in the basal layer of the epidermis was the striking feature at the site of mononuclear hugging. That these mononuclear cells are possibly responsible for selective destruction of melanocytes (auto-destruction) and that vitiligo is perhaps slow reacting auto-immurie disorder of delayed hypersensitivity -type, have been suggested on histological grounds.

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Case records of 690 patients with secondary syphilis were analysed. Epidemiological, clinical and serological aspects are discussed. Rose-Waaler test was found to be positive in 4 cases. Its significance in relation to involvement of musculo-skeletal system is discussed. Histopathological examination was carried out in 27 patients and 7 of them showed features of granuloma. The importance of this finding in relation to appearance of tertiary manifestations is discussed.

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Fifty patients with lepromatous leprosy were studied. Involvement of liver was observed in 90 percent of the cases. Fatty degeneration was seen in two cases only. Amyloid deposit was not seen in any of them.

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