Seventeen cases of Stevens-Johnson syndrome are reported. Clinical manifestations and laboratory findings have been described. Only 5 cases had classical triad of conjunctivitis, stomatitis and urethritis with skin lesions. Four patients had corneal ulcerations. There were 3 deaths. Sulfonamides, acetylsalicylic acid, thia-cetazone, isoniazide, phenylbutazone, oxyphenbutazone and streptopenicillin were the responsible drugs for the development of Stevens-Johnson syndrome in I I cases, whereas no cause could be ascertained in 6 cases.

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A case of precocious tertiary syphilis is reported. The reasons for the early onset of tertiary syphilis is reported. The reasons for the early onset of tertiary stage and positivity of Rose Waaler test are discussed.

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Xeroderma pigmentosum (XDP) is a hereditary disorder characterized by early development of pigmentation, atrophy, keratoscs and carcinomas occurring predominantly on light exposed skin. The disease is often fatal before the age of 20 years. Survival beyond middle age is sometimes possible in mild cases with adequate treatment. Two patients with XDPaged 60years and 75 years were admitted in the skin department of Rajendra Hospital Patiala. Survival upto 70 years has been reported by Herxheimer in 1947. S urvival in XDP upto the age of 75 years is particularly significant in our country with abundant sunshine, which is practically impossible to avoid completely.

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Clinical patterns and manner of presentation of vitiligo in 771 cases have been studied. Both the sexes were equally affected. The disease in two third of cases had its onset at or before the age of twenty years. Multicentric onset was uncommon (1.0%). Legs were the most common initial sites involved (I 5.7%). Spontaneous repigmentation occurred in 9.6%. Family history was positive in 8.6%. In two third of the pattern was multifocal. VitWgo areata was not uncommon (seen in 21.4% of cases).

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The epithelium overlying dermal lesions of granuloma pyogenicum is invariably flattened or even ulcerated possibly due to the pressure from the underlying expansive growth. An unusual histological feature of epidermal proliferations simulating those seen overlying histiocytomas is reported in a lesion of granuloma pyogenicum from the lip. The role of dermal connective tissue appears important in induction of the epithelial changes

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The clinical efficacy of 'Histryl' elixir was studied in 30 patients suffering from various allergic dermatoses. We feel that this drug is a safe and potent antipruitic remedy and is of great value in the management of urticaria and lichen urticatus. The added advantage of this drug is that it can be administered easily to infants and children because it is available in the form of a flavoured liquid. No untoward effects were noted in this study.

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A preliminary trial of B663 (Lampreae) in vitiligo cases is reported. Thirty cases were studied. One Cap of 100 mg, B663 was given daily. Out of 30, excellent results were seen in 21 cases.

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An isolated case of Fredcrickson's type II a like-hyperlipoproteinaemia with cutaneous xanthomatoscs and aortic stenosis was observed in a 14 year old girl of a South Indian family from Seven malai, Kerala state. She had an increased I serum cholesterol level hyperlipidemia, hyperlipoproteinaemia, normotriglyceridemia and tuberous and tendinous xanthomatosis with aortic stenosis. The members of three generations of her family were normal.

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The occurrence of reactive perforating collagen sis in three members of one family is presented. A genetic abnormality of the collagen in the upper dermis is suggested as the probable cause for the disorder

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A case of larva migrans on the abdominal wall of a child of 68 days is reported. The penetration of the larva occurred immediately after birth. The disease manifested on the third day and persisted for 65 days. The lesion responded to ethyl chloride spray.

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A case of actinomycotic mycetoma is reported from Madras, India. Clinical and laboratory studies established the diagnosis. Gross microscopic features of the lesion and causative organism are described. The classification and geographic distribution of Nocardia species are discussed.

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A 50 year old male patient with subcomeal pustular dermatosis is reported. Patient has been successfully treated with dapsone 100 mg twice a day followed by 50 mg daily as a maintenance dose. The relevant literature is reviewed.

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