Retinoic acid was administered in 45 patients with grade I or grade II acne vulgarism In 10 patients it was compared in a clinical study to sulfur resorcinol shake lotion. Good to excellent response was obtained in 22 patients (48.8%) while fair response was noted in 9 patients (20.0%). In 14 patients (31.1%) there was no change. Retinoic acid was found to be effective in reducing the number of comedones to about 68-70% in both grades of acne. When compared with the shake lotion it was found to be more effective in reducing the number of come dones (70% with retinoic acid compared to 50% with shake lotion). Burning of the skin, smarting pain and irritation were the main side effects noted. Nine out of 45 patients discontinued the medication on their own as a result of side effects. This was the major problem in continuing the therapy. Retinoic acid has a significant effect on the removal of comedones as compared to the other available methods of treatment. Whilst it has only a moderate effect in reducing papulur lesions, its effect on the pustules and cysts is virtually negligible.

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A new solid transgrow medium has been for the transport, primary isolation and maintenance of Trichomonas va. Perhaps this is the first solid medium ever described for trichomonads.

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The fluorescent treponemal antibody test has been performed on cerebrospinalfluid from 397 patients of various categories. The findings indicate that this test is not merely of immunological importance but has a diagnostic value specially in problematic neurological cases of syphilitic origin.

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A familial occurrence of discoid lupus erythematosus is reported in a brother and sister.

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Two cases of mycosis fungoides, tumor d'emblee are reported. A 52 years old male presented with multiple, nodular swellings and tumours on the scalp, forehead, face, neck,

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A case of pyodenna gangrenoswn- in a girl aged 12 years has been presented, in association with ulcerative colitis. The sites of distribution of cutaneous ulcers were typical. Literature on pyoderma gangrenosum has been briefly reviewed and its astrology suggested.

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Thirty three cases suffering from different types of pyodennas were taken for study and were with framygen cream. The results obtained were quite encouraging in most of the cases. Out of the total 33 cases 10 cases showed complete improvement within one week of treatment while another 10 cases showed similar improvement in two weeks and six am needed treatment for three weeks and four had to be treated for four weeks to achieve the complete improvement Only two cases in the series did not show 100% improvement in the specified period of four weeks treatment and the maximum improvement observed in them during this period was up to 80% only.

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Total number of 50 cases were studied. The present study shows the occurrence of hypergammaglobulinaemia in folliculitis et atrophicans. The increase in gammaglobulins could not be correlated with the severity of the disease. Amino acid composition of this gammaglobulin fraction was identical with that of normal serum gammaglobulins. Part of the increase in serum proteins was found to be due to an increase in serum mucoproteins.

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A case of mycosis fungoides is being presented. The patient was admitted for itching, scaling and multiple cutaneous swellings with heapato-splenomegaly and lymph node involvement. Histopathology confirmed the diagnosis. Response to treatment with Endoxan was unsatisfactory.

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