A 40 year old male was admitted with a small firm mass in the right lumbar region for the past 3 months. On examination a hard lobulated mass measuring about 9 cm in diameter was present in the right lumbar region. It was freely mobile over the deep seated muscles. The skin over the mass was tense but not adherent. It was not tender. The lymph nodes were not enlarged. Biopsy confirmed the diagnosis.

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Seven years old boy presented with the complaint of intermittent pain right ear for the last 10 months with gradually increasing swelling of the right postaural area for the last 3 months. On examination: well built fairly nourished with no lymph node enlargement anywhere in the body. Locally, there was a 2 x 1 inch soft tender swelling behind right pinna extending on to the zygoma. There was oedema surrounding this swelling and occluding the retroauricular sulcus., The ear canal was found occluded due to sagging of posterior meatal wall. There was slight mucopurtilent discharge coming out of the car canal. Tympanic membrane was not visible. Left car was normalThere were extensive maculo-papular eruptions on the whole of the chest, abdomen and back.

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The classification and clinico-pathological review of leiomyoma cutis is presented. A case of multiple hair muscle leiomyoma in a male patient is described. Stout believes that the incidence of multiple lesions occurs twice as often in men than in women. No familial or hereditary factors were seen in the case reported, though Kleepfer reported a familial case. The painful nature of the lesions brought the patient to seek medical attention, this symptom we believe is of importance in diagnosing multiple leiomyoma. The skin biopsy confirmed our clinical diagnosis of multiple hair muscle leiomyoma.

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VDRL tests and blood grouping was carried out on 1537 blood donors and 1968 antenatal cases at Medical College Hospital, Aurangabad. There is no evidence of any association between sero-positivity for syphilis and ABO blood groups.

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This study consisted of 50 cases of acneiform lesions and hyperpigmentation over face. The lesions in all cases consisted of comedones or hyperpigmentation or a combination of both. These were confined to cheeks, temples and forehead. These lesions appeared gradually and did not get fever, itching, urticaria, lesion associated with them. The patients were mostly from low or middle socioeconomic group and they rarely used other cosmetics. Most commonly used article was medicated Mk oil called Brahmi Amla Oil 76% and 20% coconut oil. Majority of the patients reported within few months to one year but 3 patients had pigmentation for last 9 years. The interval between application of oil and onset of signs varied from 3 months to 1 year.

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We propose the following hypothesis. In leprosy the nerve fibers in the skin are primarily invaded by M. leprae (a situation comparable to inoculation with Freund's adjuvant containing emulsified nerve tissue.) The M. leprae provoke a chronic proliferative inflammatory granuloma in the skin, analogous to the chronic process produced by the mineral oil and paraffin of Freund's adjuvant. In tuberculoid leprosy in which the RES is at least partially intact there is a lymphocytic tissue response directed against nerve tissue as well as against M. leprae. As a consequence patients suffering from tuberculoid leprosy often present early in the disease with acute extensive nerve involvement while M. leprae are absent with standard methods of examination. In lepromatous leprosy by contrast the RES is efficient and the lymphocytic immune response is inadequate. Hence, all the delayed type reactions, lepromin, tuberculin and patch tests are mitigated or negative. As a consequence acute extensive nerve involvement is absent and M. leprae abound in the skin. Chronic neuritis usually occurs insidiously after several years, not as an auto-immune process (as in tuberculoid leprosy) but rather as the result of the chronic continuous presence of M. leprae in the nerves.

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A case of chromoblastomycosis presenting as a chronic painless subcutaneous solitary nodule is presented. Though it is known to produce eosinophilic pattern of blood picture, our case had normal blood picture.

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Clinical observations on 8 cases of Darier's disease which is quite rare have been reported, revealing dominant inheritance and low marriage rate with histologically proved mucous membrane lesions in one case.

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