The device consists of two parts (1) the "cutting portion" and (2) the "supporting framework". The cutting portion is composed of 2 stainless steel blades 45 mm long, fixed parallel to each other at a distance of 2 mm by means of a perspex plate of suitable dimensions. Two brass tubes with sharp edges having a diameter of 2.5 mm were fixed at a distance of 2.5 mm from the sides of blades midway along their length, taking care that the cutting edges of the blades and the brass tubes were in the same plane. The supporting framework consists of a platform closed from the back and the sides and made of a suitable size to hold a 75x25mm microscopic slide. The sides of this framework contained 2 iron springs, one on each side, which supported the cutting portion in such a way that in the position of rest, the cutting edges of the blades and the brass tubes stood sufficiently clear of the platform. A microscopic slide bearing the agar film can be placed on the platform and the cutting portion pressed downwards. On releasing the pressure, the cutting portion springs back to its original elevated position. The slide can then by taken out, the cut portions of agar removed and the slide subjected to immunoelectrophoresis.

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The present study was undertaken to assess, in the hospital population, cutaneous manifestations of systemic diseases as also systemic disorders commonly associated with certain specific or non-specific skin lesions. No attempt was made to establish a cause and effect relationship. It was observed that various systemic diseases presented with a very wide variety of cutaneous lesions and with the exception of metastatic lesions secondary to internal malignancies none of them were specific. Internal malignancies and diabetes mellitus were for instance frequently associated with generalised pruritus. The significance of the presence of herpes zoster and purpura in the elderly is also similar to that of pruritus. The detection of a hyperglycemic state in approximately one third of the patients with recurrent pyococcal infections and in one half of the patients with chronic monilial infections, compared to a mere 2.0% in normal urban population in North India is a strong circumstantial evidence in favour of an association between diabetes mehitus and chronic recurrent pyococcal and monilial infections. Other endocrinal disorders like hypothyroidism, Addison's disease and Cushing's syndrome presented characteristic skin changes in a vast majority of patients. The importance of skin lesions in the so-called collagen diseases was particularly sng. In fact in aft patients, anention to the presence of a systemic disease was first attracted by the presence of skin lesions. A word of caution, based on our findings is that while some of these skin lesions are nolinfrequendy associated with a systemic disease, a majority is still without any sys involve lesions sbmu only be cmgfdered as gui & -s ad am , couin exceptions, as the diagnostic or cardinal signs for any of these diseases.

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Seventy cases of drug eruptions were studied in detail. The sex incidence was equal. The incidence was 1 % of the total O P D attendance. The maximum incidence of 40 cases (57%) was seen in the age group of 20-40 years. The paediatric and geriatric age group showed a low incidence. 30% of cases presented were due to self medication and 70% due to medical administrations of drugs. In this study, we were greatly impressed by the mimicking capacity of different drugs to imitate known nasological entities. This incidently emphasises the need for proper history taking in each such cases. Eighteen cases presented erythematous macules (exanthematic eruptions) - these were most frequently encountered, 17 cases - hyperpigmented macules (fixed eruptions), 9 cases urticarial, 6 haemoffhagic, 4 each of papulosquamous and vesicular nature, 3 cases presented with only pruritus and 8 cases with the erythema multiforme - Steven - Johnson - toxic epidermal necrolysis picture. One case of exfoliative dermatitis.

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A total of 140 patients with acute uncomplicated gonorrhoea were treated with four different schedules i.e. a single dose of 900 mg of demethylchloretetracycline, total doses of 1350 mg of demethylchlortetracycline over 3 days, 1800mg of demethylchlortetracycline over 2 days of 1.2 mega units of PAM. The lure rates were assessed on the absence of further history of fresh sexual exposure; all recurrences occurring in 14 days were classified as failures. Over all results have shown that a total dose of 1800 mg of demethylchlortetracyline is better than the other schedules of demethylchlortetracycine and PAM.

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A case of pseudoxanthoma elasticum with characteristic skin and purpuric lesions detected during the course of investigations for Jaundice with no other cardiovascular and ocular manifestations no family history of PXE and no history of consanguinity of marriage in parents, is reported. Literature is briefly reviewed.

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Two cases of epidermodysplasia verruciformis with not only papular lesions, but also with macular lesions are reported. In both the cases family history was negative. In one case, lesions were present for 2 years, and in the other, lesions were present for one year.

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