Certain fungi grow on hairs after causing them to fracture. The observation that these fungi, the dermatophytes, will penetrate hairs in vitro gives no indication of the chemical process involved but enzyme activity has long been recognized as a likely explanation. Such proteoloytic enzymes which might be responsible have not so far been well characterized. Comparatively little work has been carried out on the proteolytic enzyme of fungi particularly pathogenic fungi.

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Though prostitution has always been blamed for the spreading of venereal infection and though the statistical possibility is much higher among them, so far no study could prove that the prostitutes are the main source. But various studies have conclusively proved

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Hair penetration test was done on hairs affected with pili torti and leucotrichia annularis, and also on hirsutism hairs produced by prolonged corticosteroid therapy. Normal hairs were used as control. The hairs used in these experiments did not show either more or less suspectibility to fungal attack in vitro in comparison to normal hair.

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The gonococcus has been found to grow well in artificial culture in a basal medium of Trypsin-digest-Beef-Muscle extract Agar enriched with the hen's egg. This egg enrichment medium has been compared with the same basal medium enriched with Ascitic Fluid and the Bacto G C Medium Base supplemented with Bacto Haemoglobin and Yeast Concentrate, by assaying them in parallel series for the primary diagnostic culture isolation of the gonococcus, from male and femal patients. In preliminary trials, the egg enriched medium has been found to support the growth and maintenance of several local fresh strains of the gonococcus, as well as the other two conventional enrichment media, in current use. The Egg, apparently contains yet unnamed special nutrient factor or factors required by the gonococcus to grow in artificial culture. Egg can be obtained more conveniently anywhere than the other conventional source or growth factors from Blood, Serum, Ascitic fluid and Yeast Extract in quality and quantity. The technique for preparation of the egg medium described lends itself with ease, for application in practice, in bacteriological laboratories anywhere. Therefore, the egg medium suggests itself as a good alternative culture medium that maybe used with advantage in the routine diagnosis of gonorrhoea everywhere. The various aspects of the egg medium is discussed and it is offered for more extensive study of potential worth discovered in this study.

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A peculiar association of high frequency of leg ulcers with monsoon season has been discussed here. We have tried to explain the pathogenesis of this higher seasonal incidence.

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A case of pyoderma gangrenosum in a child, who had fever, dysentery with loss of fluid and electrolytes is reported and the relevant literature reviewed.

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