Observation during the period of surveillance of the effects of penicillin and bismuth therapy in late syphilis with neuroaxis involvement and critical study and analysis of two groups of cases of neuro-axis involvement have been presented. Interpretation of progress in treatment and therapeutic efficacy have been made by (a) clinical analysis in the pre and post treatment phase in the first group of 51 cases and by (b) a CSF syndrome study in 250 cases of neuro-axis involvement by a serial examination of the CSF from the pretreatment period to and during the post treatment phase of varying periods of 'Zone Level days, up to 900 days in many cases. The limitations in judging the therapeutic efficacy and progress in treatment solely by clinical evaluation in neuro-syphilis and the importance of CSF serial study forming the most substantive basis as a precise and definite indicator to estimate and determine the progress of treatment and capable of accurate interpretation to evaluate up to the extreme degree has been brought out. Treatment schedule was 9.6 MU of penicillin and 3 courses of bismuth of 10 injection of 0.2 Grams each. Total of 6 Grams and the findings represent the results achieved from a combined therapy schedule. Treatment results in terms of improvement in clinical manifestations and of achievement of CSF normality have been indicated as diagramatic and graphic representations. In the CSF findings 83.5 % became normal by the third zone going up to 93.6 % by the 9th zone of Observation period. The importance of bismuth in combination with penicillin in treatment of late syphilis has been brought out although no comparative control study without has been carried out. Results achieved from a combined therapy schedule appear to be highly satisfactory.

[ABSTRACT]   Full text not available   

It can be reasonably assumed that venereal disease are bound to be with us as long as there is sexual promiscuity and there is reservoir of infection. The prevention of VD is a neglected subject in our country even when the quantum is not known. In the absence of any legislation on control of VD e.g. compulsory free treatment of infected patients, free examination and compulsory reporting by physicians, serological examination for syphilis in all cases where certification of physical fitness is obligatory, and compulsory ante-natal blood testing, the venereal diseases in our country will be difficult to control. With the rapid industrialisation in the country which will result in increased urbanisation due to shifting of population from rural to urban areas, specially of the younger age group, the incidence of venereal diseases is likely to remain at a constant level and hence venereal diseases control measures should be given greater importance in future.

[ABSTRACT]   Full text not available   

The pattern of venereal diseases has certainly changed quantitatively and qualitatively with the advent of chemotherapy and antibiotics, demanding not a casual acquaintance with VD as was wont in the past, but a meticulous training in the composite discipline of venereology aiming at competence in the several other disciplines so as to enable one to diagnose and treat them; and above all to prevent VD for which protective inoculatory immunisation procedures are not available.

[ABSTRACT]   Full text not available   

Full text not available