| Syphilis and Infancy PN Rangiah September-October 1961, 27(5):165-187T pallidum invades the developing human zygote of 16 weeks or older. Among untreated syphilitic pregnant women births of live, non-syphilitic infants approximated 18% while foetal deaths, prematurity or the number of live born that scarcely survived the rigors of early life and died in the neonatal period, besides a proportionately large crop of unfortunate infants that developed manifest syphilitic lesions subsequently at various age periods comprised the remaining 82%. If the pregnant syphilitic women were given the appropriate, timely and adequate treatment the outcome of pregnancies very nearly equalled the results obtainable in control cases. 1030 cases of congenital syphilis were reviewed 1) 46.02% were males and 53.98% females 2) Percentage of congenital syphilitics belonging to first, second, third and fourth para went down in descending order Proportionately, finally dividing down to insignificant figures 3)A large majority of infants presented within the first 6 months of age 4) The serolo of the congenital syphilitic infants was invariably higher in dils, than that of the mother while the fathers was lower nil reactive 5) An apparently normal prenantal syphilitic infant may exhibit signs of syphilis in a few weeks after birth 6) Lesions in order of frequency with number of cases affected given in brackets were of skin (733), skeleton (467), mucocutaneous (277), visceral (133), CNS (6) 7) There was no case in the latent congenital syphlitic group 8) True latency in adult acquired syphilis is indicated by a persistent positive sero-reactivity or a rise in titre in the presence of active clinical manifestations 9) Hepatomegaly vis a vis spienomegaly was a more common finding, The routine treatment prescribed was 150,000 units or 1/2 millilitre of PAM in Oil given daily IM for 20 days. |
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