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EDITORIAL |
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IJDVL and impact factor |
p. 525 |
Saumya Panda DOI:10.4103/ijdvl.IJDVL_665_18 PMID:30117464 |
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REVIEW ARTICLES |
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Hair manifestations of endocrine diseases: A brief review  |
p. 528 |
Keshavamurthy Vinay, Gitesh U Sawatkar, Sunil Dogra DOI:10.4103/ijdvl.IJDVL_671_17 PMID:30027913
Hair disorders are common in clinical practice and depending upon social and ethnic norms, it can cause significant psychosocial distress. Hair growth, cycling and density are regulated by many endogenous factors, mainly circulating hormones. Thus, diseases affecting the endocrine system can cause varied changes in physiological hair growth and cycling. Diagnosis and treatment of these disorders require a multidisciplinary approach involving a dermatologist, gynecologist and an endocrinologist. In this review, we briefly discuss the influence of hormones on the hair cycle and hair changes in various endocrine disorders.
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Safety of important dermatological drugs (retinoids, immune suppressants, anti androgens and thalidomide) in reproductively active males with respect to pregnancy outcome: A brief review of literature  |
p. 539 |
Piyush Kumar, Anupam Das, Niharika Ranjan Lal, Sourabh Jain, Anupama Ghosh DOI:10.4103/ijdvl.IJDVL_77_17 PMID:29998864
Paternally transmitted damage to offspring is recognized as a complex issue. Each parent contributes 23 chromosomes to a child; hence, it is necessary to know the effects of both maternal and paternal pre-and peri-conceptional exposure to drugs on pregnancy outcome. While there are many studies on the effects of maternal drug exposure on pregnancy outcome, literature on paternal exposure is scarce. Of late however, paternal exposure has been receiving increasing attention. We present a brief review on the safety of commonly used drugs in dermatology, focused on retinoids, immune suppressants, anti androgens and thalidomide.
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ORIGINAL ARTICLES |
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The effectiveness of adding low-level light therapy to minoxidil 5% solution in the treatment of patients with androgenetic alopecia  |
p. 547 |
Gita Faghihi, Samaneh Mozafarpoor, Ali Asilian, Fatemeh Mokhtari, Alireza Asemi Esfahani, Behzad Bafandeh, Saeid Nouraei, Mohammad Ali Nilforoushzadeh, Seyed Mohsen Hosseini DOI:10.4103/ijdvl.IJDVL_1156_16 PMID:30027912
Background: Androgenetic alopecia is the commonest type of alopecia affecting over half of men and women. Low-level light therapy is a new technique for stimulating hair growth in both genders.
Aims: To overcome the shortcomings of previous epidemiological studies and a lack of controlled clinical trials on the subject, this study compared the effectiveness of adding low-level light therapy to minoxidil topical solution in the treatment of androgenetic alopecia in patients presenting to two skin clinics in Isfahan, Iran during 2014–2015.
Materials and Methods: This clinical trial included 50 patients aged 17–45 presenting to Khorshid and Alzahra educational centers and skin diseases research center for androgenetic alopecia during 2014–2015. The patients were randomly divided into a control and a case group. The case group received topical minoxidil 5% solution plus low-level light therapy twice per day. The control group was given the same topical solution and a laser comb system that was turned off to act as a placebo. Changes in patients' hair density and diameter and its overall regrowth as well as their satisfaction with the treatment were assessed at months 0 (baseline), 3, 6, 9 and 12.
Results: The percentage of recovery from androgenetic alopecia and the patients' satisfaction with their treatment were significantly higher in the case group compared to the control group. The patients' mean hair density and diameter were found to be higher in the case group after the intervention compared to the control group.
Limitations: The study limitations included patient compliance, small sample size, patient insight due to novelty of the method and clinical judgement.
Conclusion: As a new method of treatment, low-level light therapy can help improve the percentage of recovery from androgenetic alopecia and increase patients' satisfaction with their treatment.
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End of the road for terbinafine? Results of a pragmatic prospective cohort study of 500 patients |
p. 554 |
Sanjay Singh, Prakriti Shukla DOI:10.4103/ijdvl.IJDVL_526_17 PMID:29893296
Background: There is a general impression among dermatologists in India that terbinafine has been losing its effectiveness in dermatophytoses over the past few years, but there are no recent data to support this.
Aims: To determine the effectiveness of terbinafine in tinea corporis, tinea cruris and tinea faciei with a pragmatic prospective cohort study.
Methods: A sample size of 361 patients was calculated taking a 5% margin of error and a 95% confidence level. Five hundred patients with tinea corporis, tinea cruris and tinea faciei confirmed by potassium hydroxide microscopy received oral terbinafine (5mg/kg/day) and topical terbinafine 1% applied twice daily for 4 weeks. Patients were evaluated at 2 and 4 weeks. Cure was defined as total clearance of lesions and negative microscopy.
Results: Patients who came for follow-up at 2 and 4 weeks numbered 357 and 362 respectively. Ten patients were cured at 2 weeks (cure rate 2%, 95% confidence interval 1.0–3.7%, intention-to-treat analysis) and 153 patients were cured at 4 weeks (cure rate 30.6%, 95% confidence interval 26.7–34.8%).
Limitations: Culture and antifungal susceptibility testing were not performed since this was a pragmatic study. There was also no follow up after completion of treatment to check for relapses, but the poor response makes this less relevant.
Conclusion: The effectiveness of terbinafine in dermatophytosis was abysmal in this study.
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Reduced immunohistochemical expression of CCN3 in vitiligo |
p. 558 |
Adriane Reichert Faria, Juliana Elizabeth Jung, Caio Cesar Silva de Catro, Lucia de Noronha DOI:10.4103/ijdvl.IJDVL_954_16 PMID:29998862
Background: Defective adhesion seems to be involved in the chronic loss of melanocytes observed in vitiligo. Recent findings showed an association of genetic variants of an adhesion gene with vitiligo and reduced immunohistochemical expression of some adhesion molecules in vitiligo skin.
Aims: To compare CCN3 immunohistochemical expression in lesional and non-lesional epidermis of individuals with vitiligo.
Methods: A total of 66 skin specimens from 33 volunteers with vitiligo were analyzed by immunohistochemistry using anti-CCN3 antibodies. Absence of topical or systemic treatment for vitiligo over the previous 30 days and availability of an area of non-lesional skin for biopsy at least 15 cm away from any vitiliginous macules were the main inclusion criteria.
Results: A significant reduction of CCN3 expression was observed in lesional skin as compared to non-lesional skin (P = 0.001).
Limitations: Paraffin embedded skin samples do not allow investigation by molecular biology methods. Not all samples allowed analysis due to the lamina preparation technique. Complete clinical data was not available for all patients.
Conclusion: Our results support the hypothesis of impaired cell adhesion in vitiligo suggested by genetic studies. The pattern of immunohistochemical expression suggests that vitiligo might be an epithelial disease and not just a melanocyte disorder.
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Oral sex related knowledge and oral sex behavior among homosexual and heterosexual men in Belgrade: A cross-sectional study |
p. 563 |
Milan D Bjekic, Sandra B Sipetic-Grujicic, Hristina D Vlajinac, Aleksandra M Nikolic DOI:10.4103/ijdvl.IJDVL_454_17 PMID:29735814
Background: Although the risk of sexually transmitted infections is far greater during vaginal and anal sex than during oral sex, increasing practice of oral sex and low rates of barrier method use will probably increase the relative importance of oral sex as a route of transmission for genital pathogens.
Aims: The aim of this study was to evaluate knowledge and attitudes about oral sex and sexually transmitted infections, as well as oral sex practices, both among heterosexuals and homosexual men and to compare those two groups.
Materials and Methods: In this cross-sectional study, data were collected from consecutive sexually active male patients who ever had oral sex and who attended counselling for sexually transmitted infections at the City Institute for Skin and Venereal Diseases in Belgrade from March to June 2016. One dermatologist interviewed all participants.
Results: The study included 359 men who ever had oral sex, 95 (26.5%) homosexual and 264 (73.5%) heterosexual men. In comparison with heterosexual men, homosexual men had considerably more lifetime sexual partners and oral sex partners during the past 3 months, and significantly more frequently practiced oral-anal sex. Oral-sex related knowledge of all participants was unsatisfactory [correct answers were given by 95 (26.5%) to 277 (77.2%) participants], but it was significantly better in homosexual men than in heterosexual. Frequency of condom use and human immunodeficiency virus testing was also significantly higher in the case of homosexual than heterosexual men.
Limitations: The study was not performed in representative sample of population. It was restricted to the patients. Consequently it is questionable whether the results obtained could be generalized.
Conclusion: Oral sex related knowledge deficits and risky oral sex practice exist in both homosexual and heterosexual men. These findings indicate a need for effective public health campaign and patient education about the risks of unprotected oral sex.
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CASE REPORT |
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Primary cutaneous cribriform apocrine carcinoma: Case report and literature review |
p. 569 |
Jiann-Der Wu, Chih-Hsuan Changchien, Kai-Sheng Liao DOI:10.4103/ijdvl.IJDVL_830_16 PMID:29735815
Primary cutaneous cribriform apocrine carcinoma is a rare but distinct variant of primary cutaneous apocrine carcinoma and it is considered a low grade malignancy. We herein present a case of primary cutaneous cribriform apocrine carcinoma at the neck of a 26-year-old female. The tumor features a relatively well-circumscribed border and multiple aggregations of mildly pleomorphic epithelial cells with large ovoid nuclei, small nucleoli and abundant eosinophilic cytoplasms. Cribriform and tubular structures are the major architectural patterns. The primary differential diagnosis is cutaneous metastasis from a cribriform visceral carcinoma; others include primary secretory carcinoma of the skin, adenoid cystic basal cell carcinoma and primary cutaneous adenoid cystic carcinoma.
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BRIEF REPORT |
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Serum macrophage migration inhibitory factor levels in leprosy patients with erythema nodosum leprosum |
p. 573 |
Frainey Bansal, Tarun Narang, Sunil Dogra, Keshavamurthy Vinay, Seema Chhabra DOI:10.4103/ijdvl.IJDVL_591_16 PMID:28656911
Background: Erythema nodosum leprosum is an immune-mediated complication of leprosy which causes significant morbidity. Biomarkers in the pathogenesis of erythema nodosum leprosum are not yet fully determined.
Aim: To determine macrophage migration inhibitory factor levels in the sera of leprosy patients with erythema nodosum leprosum and to correlate the same with clinical parameters.
Methods: This cross-sectional study included 37 consecutive leprosy patients with active erythema nodosum leprosum and 31 age- and sex-matched controls. Detailed clinical history and examination findings were recorded including the severity and frequency of erythema nodosum leprosum. Slit skin smears and histopathologic examination were done in all patients at baseline. Serum macrophage migration inhibitory factor levels were determined using an enzyme-linked immunosorbent assay.
Results: Most of our patients were males (78.4%) and suffering from lepromatous leprosy (27, 73%) with a mean initial bacillary index of 3.38 ± 1.36. Recurrent and chronic patterns of erythema nodosum leprosum were seen in 15 (40.5%) and 6 (16.3%) patients, respectively. Most (86.5%) of our patients presented with moderate to severe erythema nodosum leprosum. The mean serum macrophage migration inhibitory factor level was 21.86 ± 18.7 ng/ml among patients while it was 11.78 ± 8.4 ng/ml in the control group (P < 0.01). There were no statistically significant correlations of macrophage migration inhibitory factor levels with erythema nodosum leprosum frequency or severity.
Limitation: Serum macrophage migration inhibitory factor levels in leprosy patients with no erythema nodosum leprosum and in patients with other inflammatory and autoimmune conditions were not assessed. Hence, this study falls short of providing the predictive value and specificity of higher macrophage migration inhibitory factor concentrations in serum as a biomarker of erythema nodosum leprosum.
Conclusion: Macrophage migration inhibitory factor levels are elevated in erythema nodosum leprosum patients as compared to controls. A larger sample size and macrophage migration inhibitory factor gene polymorphism analysis will be needed to elucidate the role of this pro-inflammatory cytokine in erythema nodosum leprosum.
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QUIZ |
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Congenital asymptomatic papule on the lower eyelid |
p. 578 |
Keshavmurthy A Adya, Aparna Palit, Arun C Inamadar DOI:10.4103/ijdvl.IJDVL_999_16 PMID:29067936 |
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IMAGES IN CLINICAL PRACTICE |
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Localized atrophy with surrounding hair growth in a case of alopecia areata treated with intralesional steroids, using a needle-less injector |
p. 581 |
Feroze Kaliyadan, Abdulaziz Alkhateeb, Krishna Swaroop DOI:10.4103/ijdvl.IJDVL_297_17 PMID:29956680 |
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LETTERS TO THE EDITOR - LETTERS IN RESPONSE TO PREVIOUSLY PUBLISHED ARTICLES |
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Letter in response to the previously published article “Familial gigantic melanocytosis” |
p. 583 |
Manoj Pawar DOI:10.4103/ijdvl.IJDVL_273_18 PMID:30073985 |
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Authors' reply |
p. 584 |
Kinjal D Rambhia, Sushma Chowdhary, G Venkateswara Rao, Uday S Khopkar DOI:10.4103/ijdvl.IJDVL_451_18 PMID:30147109 |
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Seborrheic melanosis and dermoscopy: Lumping better than splitting |
p. 585 |
Arshdeep, Sidharth Sonthalia, Feroze Kaliyadan, Enzo Errichetti, Abhijeet Kumar Jha, Aimilios Lallas DOI:10.4103/ijdvl.IJDVL_175_18 PMID:30106019 |
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Authors' reply |
p. 587 |
Shyam Verma, Laxmisha Chandrashekhar DOI:10.4103/ijdvl.IJDVL_620_18 PMID:30117463 |
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LETTERS TO THE EDITOR - CASE LETTERS |
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A solitary cutaneous metastasis from colon adenocarcinoma: Dermoscopic and confocal microscopy features |
p. 589 |
Ausilia Maria Manganoni, Marta Fusano, Laura Pavoni, Laura Pizzati, Francesca Consoli, Marina Venturini, Arianna Zanca, PierGiacomo Calzavara-Pinton DOI:10.4103/ijdvl.IJDVL_304_17 PMID:30073979 |
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Linear atrophoderma of Moulin: A rare entity |
p. 591 |
Vidya Deepak Kharkar, Bhagyashri Ambarnath Abak, Sunanda Arun Mahajan DOI:10.4103/ijdvl.IJDVL_136_17 PMID:30106014 |
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Wells syndrome in a patient receiving adalimumab biosimilar: A case report and review of literature |
p. 594 |
Garima Dabas, Dipankar De, Sanjeev Handa, Debajyoti Chatterjee, Bishan Das Radotra DOI:10.4103/ijdvl.IJDVL_636_17 PMID:30058563 |
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Verruciform xanthoma of the penis: A rare case with an unusual clinical morphology |
p. 600 |
Goncagul Babuna Kobaner, Ozgur Demir, Sule Ozturk Sari, Can Baykal, Nesimi Buyukbabani DOI:10.4103/ijdvl.IJDVL_733_17 PMID:30106016 |
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LETTERS TO THE EDITOR - STUDY LETTER |
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Excision of basal cell carcinomas smaller than 1 cm with 2 mm safety margins: Lateral margin adequacy evaluated by double-bladed scalpel method |
p. 603 |
Gabriela R Haddad, Hélio Amante Miot, Mariangela Esther Alencar Marques, Juliano Vilaverde Schmitt DOI:10.4103/ijdvl.IJDVL_462_17 PMID:30073980 |
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LETTERS TO THE EDITOR - OBSERVATION LETTERS |
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Anti-RO 52-positive systemic sclerosis sine scleroderma with multisystem involvement and recurrent vasculitis |
p. 607 |
Angoori Gnaneshwar Rao, Syeda Saba Farheen, Uday Deshmukh Reddy, Amit Kolli, K Aparna, J Kranthi, Ruhi Haqqani, T Sandhya Rani DOI:10.4103/ijdvl.IJDVL_670_17 PMID:30073982 |
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Injection-site reaction to ixekizumab histologically mimicking lupus tumidus: Report of two cases |
p. 610 |
Marta Prieto-Barrios, Jose Luis Rodriguez-Peralto, Cristina Vico-Alonso, Virginia Velasco-Tamariz, Alba Calleja-Algarra, Pablo Luis Ortiz-Romero, Raquel Rivera-Diaz DOI:10.4103/ijdvl.IJDVL_786_17 PMID:30073991 |
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Polymorphic presentation of disseminated cutaneous rhinosporidiosis in an immunocompetent individual |
p. 614 |
Swetalina Pradhan, Chandra Sekhar Sirka, Manas Ranjan Baisakh DOI:10.4103/ijdvl.IJDVL_52_18 PMID:30073987 |
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Photodynamic therapy for acne conglobata of the buttocks: Effective antiinflammatory treatment with good cosmetic outcome |
p. 617 |
Francesco Borgia, Mario Vaccaro, Roberta Giuffrida, Serafinella P Cannavò DOI:10.4103/ijdvl.IJDVL_683_17 PMID:30073983 |
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Pleomorphic hyalinizing angiectatic tumor of soft parts with unusual lipoma-like clinical morphology |
p. 619 |
Zoltan Szep, Alexandra Majernikova, Boris Rychly, Juraj Majtan DOI:10.4103/ijdvl.IJDVL_693_17 PMID:30073988 |
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Hypopigmented and acneiform lesions: An unusual initial presentation of adult-onset multisystem Langerhans cell histiocytosis |
p. 621 |
Anuradha Bishnoi, Dipankar De, Geeti Khullar, Davinder Parsad, Sanjeev Handa, Vikarn Vishwajeet, Uma Nahar Saikia, Gaurav Prakash DOI:10.4103/ijdvl.IJDVL_639_17 PMID:30106015 |
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Distal infection of the middle finger caused by Mycobacterium abscessus |
p. 626 |
Daniel Morgado-Carrasco, Constanza Riquelme-Mc Loughlin, Xavier Fusta-Novell, Adriana Garcia, Pilar Iranzo-Fernandez DOI:10.4103/ijdvl.IJDVL_929_17 PMID:30106018 |
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LETTERS TO THE EDITOR - THERAPY LETTER |
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Laser-assisted surgery and bioscaffold for the treatment of rhinophyma |
p. 629 |
Elisabetta Merigo, Luigi Cella, Aldo Oppici, Carlo Fornaini DOI:10.4103/ijdvl.IJDVL_781_16 PMID:29327702 |
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IMAGES IN CLINICAL PRACTICE |
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Massive cutaneous nodules in a 92-year-old man |
p. 632 |
Ferran Ballescá, Aram Boada, Carlos Ferrándiz DOI:10.4103/ijdvl.IJDVL_514_17 PMID:29536973 |
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RESIDENTS’ PAGE |
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Gabapentin and pregabalin in dermatology |
p. 634 |
Asit Mittal, Chesta Agarwal, Manisha Balai, Ayush Taneja DOI:10.4103/ijdvl.IJDVL_480_17 PMID:29855453 |
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QUIZ |
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A verrucous plaque on the intergluteal cleft |
p. 641 |
MD Fernández Ballesteros, E Gómez Moyano, M Ayala Blanca, S Simonsen DOI:10.4103/ijdvl.IJDVL_805_16 PMID:28948943 |
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BOOK REVIEW |
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Essentials of dermatology and sexually transmitted diseases: An illustrated synopsis |
p. 643 |
Arijit Coondoo, Anupam Das DOI:10.4103/ijdvl.IJDVL_511_18 |
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NET LETTERS |
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Identification of a novel missense mutation in the NOD2 gene in a Chinese child with early-onset sarcoidosis |
p. 645 |
Xiaopo Wang, Xiaofeng Zhang, Wei Zhang, Jianfang Sun DOI:10.4103/ijdvl.IJDVL_645_16 PMID:29067935 |
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A rare presentation of keratosis follicularis spinulosa decalvans in female twins |
p. 645 |
Rishabh Kumar Chauhan, Saumya Sankhwar, Ruchika Tripathi, SS Pandey DOI:10.4103/ijdvl.IJDVL_524_16 PMID:28928337 |
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Angiospastic macules of Bier: A cause of mottled skin |
p. 645 |
Cesar Daniel Villarreal-Villarreal, Juan Carlos Robles-Mendez, Angel Eduardo Guerra-Vazquez, Jorge Ocampo-Candiani DOI:10.4103/ijdvl.IJDVL_915_16 PMID:29098991 |
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ANNOUNCEMENT |
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IADVL Invites Application for Editor, IJDVL (2020-22)
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p. 646 |
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