In 50 controls and 50 patients with hyperpigmentation serum copper, ceruloplasmin and non-ceruloplasmin copper have been estimated. Significantly higher levels of serum copper and non-ceruloplasmin copper have been detected in hyperpigmentary disorders. In toxic melanodenna and in females with melasma the main rise had been in non-ceruloplasmin copper, importance of which has been high-lighted.

The paper deals with 588 cases of skin diseases studied histopathologically between 1968 and 1974. Neoplastic and Hansens's diseases have not been included in this study. The diseases have been studied with emphasis on their incidence, types and clinicopathological features. Psoriasis, lichen planus, vitiligo, chronic dermatitis, eczema, lupus vulgaris, mofluscum contagiosum etc. are reported in this paper. The results are presented and discussed.

Fifteen cases of Darier's disease were studied. Males and females were in the ratio of 3:2. The disease appeared between the ages of 5 and 16 in majority (80%) of the patients. Family history was positive in only 60% cases. Itching was the main symptom in 2/3rd (66.6%) of cases. Seven cases experienced aggravation of the disease in summer. Recurrent skin infection and eczematisation were present in 5 cases. Majority of patients had typical lesions. Severity of the disease was directly related to its duration. Acrokeratosis verruciformis like lesions over the hands and feet were present in all the cases and 86.6% of cases had palmoplantar keratoderma. Mucosal lesions were seen in 73.3 % of cases. These unusual findings are not often stressed in clinical practice and need to be highlighted. Leucoderma guttate yet another unusual finding was seen in 20% of cases.

Skin sugar levels were measured in twenty psoriatic patients and normal controls. No sighificant difference was fmA in their levels in involved and skin from die nomw skin.

A case of Papillon - Lefevre syndrome is being reported.

A case of symmetrical progressive erythrokeratoderma in a 32 year old male patient noticed at the age of 27 years has been described.

A Sindhi family with psoriasis and abnormal haemoglobin Hb D in some of the members of the family isreported. The significance of this finding as an added genetic marker of psoriasis is discussed.

Three cases of pseudoxanthoma elasticum are described. One case has features of Gronblad Strandberg syndrome with lepromatous leprosy. The other two cases are reported in siblings. A short review of literature is given.

A case of pellagra who had psychosis, dermatitis and gastrointestinal system involvement in the form of constipation has been described. In this case mental symptoms in the form of insomnia appeared prior to dermal lesions. The case was successfully treated both for the mental and skin condition with nicotinamide and other ancillary treatment.

Two cases of MF have been reported, one in a middle aged male having MF with erythroderrna, poikiloderma and tumours, developing in a short period, and: second in a middle aged: female having 'd' emblee' form of the disease.

An attempt to study etiologic factors in 500 cam of genital ulcers in maleswas made tion was found to be the commonest cause (86.8 percent). Trauma and drug reaction were found in 3.8 and 0.2 percent respectively. Cancer was responsible in 1.2 percent and 8 percent remained undiagnosed.