By way of introduction a brief review of the, relevant literature is made in respect of the studies of the sensitivity both in vitro and in vivo of gonococci to antibiotics and of the evolution of the different treatment schedules in treatment of gonorrhoea. A study of case records of 157 patients suffering from acute of gonorrhoca is made as to the effect of penicillin and a few other antibiotics. The case records of 35 PAM treatment failure cases are studied with reference to certain factors such as age, marital status, duration of illness, and previous treatment. 22.3% of patients treated with 0.6 mega PAM proved to be treatment failures. The teenagers have greater chances of escaping resistant gonorrhoea. Duration of illness is longer in more number of TR failure cases than in the successful. Previous attacks of gonorrheoa did not affect the incidence of TR failure. In vitro studies of sensitivity would have been highly useful to choose the dosage and the preparation of the antibiotic and the course of treatment. Penicillin failure is a real problem to be reckoned with but is easily surmountable as the insensitive strains are still susceptible to other antibiotics. Chloramphenicol has been found to effect a clinical cure satisfactorily in the penicillin failure cases.

This article surveys the literature regarding penicillin resistant gonococci. Treatment failure could be due to inadequate dosages of penicillin, relapse or reinfection or if the focus of infection is closed. In the midst of such reported resistant cases penicillin can be used safely in an adequate dosage.

TWO hundred cases with hyperpigmented patches on face were treated with PABA given in actinic hyperpigmention orally. The results were better than hyperpigrnentation due to other causes. A theoretical conception based on the pharmacology of PABA and its use m the treatment of hyperpigmented patches of face is discussed. This is a pilot study and further evaluation of the drug will have to be undertaken.

79 % of cases in this study while SGPT was found to be within normal limits with one exception. The alkaline phosphatase activity ranged from 10 to 36 units (King and Armstrong units) with a mean of 16.9 units and this enzyme activity was elevated in 42 % of the cases. The PPD oxidase activity ranged from 0.208 to 0.658 with exception at 0.149 and the mean was 0.350. Eighty percent of vitiligo patients had value lower than normal. There was no correlation between the activities of the enzymes studied in this disease.

A factor concerned with virulence of N. Gonorrhoeae and of lipopolysaccharide in nature has been identified serologically and described in this study. The current views on the antigenic structure of N gonorrhoea has been re-examined and discussed.

Clinical features of 85 cases of Donovanosis diagnosed in General Hospital.. Pondicherry are described. Nomenclature of the disease is discussed. Venereal transmission of the disease, is favoured. Increasing resistance of the causative organism of the disease to streptomycin is stressed.