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REVIEWS |
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Immunofluorescence of the immunobullous disorders Part two: The clinical disorders |
p. 255 |
SC Huilgol, BS Bhogal, MM Black PMID:20952983The immunofluorescence findings in the immunobullous disorders are reviewed together with a summary of clinical and histopathological findings |
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STUDIES |
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Evaluation of H2 receptor antagonists in chronic idiopathic urticaria |
p. 265 |
YC Minocha, KB Minocha, VK Sood, A Dogra PMID:20952984H1-antagonist (hydroxyzine hydrochloride) in dosage of 10 mg-25 mg thrice a day failed to elicit satisfactory response in 60 out of 170 patients of chronic idiopathic urticaria. Additional administration of H2-antagonist (cimetidine) in dosage of 200 mg four times a day, in patients not responding earlier to H1-antagonist alones exhibited moderate to good improvement of various parameters of urticaria in approximately 85% patients |
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Role of colchicine in primary localised cutaneous amyloidosis |
p. 268 |
K Chakravarty, M Chanda PMID:20952985Fifteen patients with primary localised cutaneous amyloidosis (PLCA), of which 8 had macular amyloidosis (MA) and 7 lichen amyloidosis (LA), received oral colchicine 1 mg/day in 2 divided doses for a period of 3 months. Pruritus completely disappeared in all MA patients and 30-60% diminution occurred in LA patients within 15 days. Flattening of the papules and diminution in thickness of the skin also started within one month in all LA patients, within 90 days of therapy pigmentation almost disappeared in ail patients of MA and size of papuies decreased by 80-98% in all LA patients. No significant side effect was seen in these patients due to colchicine therapy |
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A study of immunoglobulins and complements (C3 & C4) in alopecia areata |
p. 270 |
RP Sharma, DK Sharma, NK Sharma, AK Agrawal, Sharm PMID:20952986Estimation of serum Immunoglobulins (IgG, IgM and IgA) and complements (C3 and C4) was carried out in 100 cases of alopecia areata as per method described by Mancini (1965).[1] Clinically patients were divided in two groups, alopecia areata circumscribed (group I) and severe alopecia areata (group II). Significant decrease in levels of one or more Immunoglobulins were observed in most of the patients. However, Serum complements (C3 and C4) were within range of normal control values |
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Correlation of isolates from pyoderma and carrier sites |
p. 273 |
Adarsh Chopra, Ramesh Puri, RR Mittal PMID:20952987100 cases of pyoderma were studied to find out whether there is any correlation between isolates from pyodermas, normal skin and nasal flora of the individual. From each patient six swabs were taken, two each from the lesion, healthy skin distant from the lesion and anterior nares. One swab from each site was used for direct microscopic examination and the other for culture and antibiotic susceptibility study. Isolates from lesion and normal skin and/or nose were identical in 37% cases of pyodermas. Isolates from lesion and normal skin were identical in 16% of cases; from lesion and nose in 14% cases, from all the three sites i.e., lesion, skin and nose in 7%. Staphylococcus aureus was the causative organism in 35 out of these 37 cases. Only in 2 cases was Staph albus isolated. In addition, antibiotic susceptibility pattern of the isolates were also the same in 12 out of these 37 cases |
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A clinico-aetiological profile of 375 cases of lichen planus |
p. 276 |
Dilip Kachhawa, Vandana Kachhawa, G Kalla, L Gupta PMID:20952988The study of clinical, histopathological and aetiological pattern, of lichen planus (LP) in 375 patients was done in this part of Western Rajasthan. The incidence of LP was 0.8%. 58.7% cases were male and maximum number of cases (46.93%) were in age group of 20-39 years. In 70.66% of patients only skin was involved while in 10.18% of cases only mucous membrane was involved. In 61.6% patients the lower extremities were involved. Familial LP was seen in 8 families. Association of LP was found with hypertension (2.4%), polymorphic light eruption (2.1%), vitiligo (1.9%) and diabetes mellitus (1.6%). 48.5% of cases showed lymphocytosis with raised ESR. Actinic LP was seen in 14.1% of cases. 13.1% of patients showed combination of typical LP or its variants to which term lichen planus variata was given |
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Dermatophytoses in a desert district of Western Rajasthan |
p. 280 |
Sanchita Karmakar, G Kalla, KR Joshi, Som Karmakar PMID:20952989Clinico-mycological study of 250 cases of dermatophytoses was undertaken in a desert district of Western Rajasthan. Incidence of dermatophytoses in this area was 8.60% with tinea cruris (34.4%) as the major clinical type followed by tinea corporis (24.0%) Incidence of tinea capitis was 16.8% and 90% of those affected were in the age group of 0-10 years. Male preponderance was observed (M:F=2:1). There were 15 cases of tinea faciei (6%), majority belonging to 0-10 years age group. Trichophyton violaceumwas isolated In majority (55.76%) from all clinical types followed by Trichophyton rubrum(42.3%) |
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Sequential clinico-histological studies in psoriasis following methotrexate therapy |
p. 284 |
S Talwar, VD Tiwari, R Lakhtakia, V Panvelkar PMID:20952990Ten cases of psoriasis were studied to see the pattern of histological resolution and to evaluate clinico-histological correlation in psoriasis following weekly methotrexate therapy. Five sequential biopsies were taken in each patient. Scaling was first to regress followed by induration and erythema in 18, 26 and 35 days, respectively. Uniform granular layer appeared in 4 days, stratum corneum became orthokeratotic in 7 days, mitotic activity got restricted to basal layer in 7 days and rete ridges elongation was reduced to half in 11 days. Mild acanthosis, cellular infiltrate and vascular dilatation pesisted even after full clinical regression. Interestingly, 5 out of 10 biopsies revealed increase in cellular infiltrate and oedema after first methotrexate pulse |
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SHORT COMMUNICATION |
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Solar urticaria |
p. 288 |
CR Srinivas, James Fergusson, Shrutakirthi Shenoi PMID:20952991A 35-year-old female and a 41-year-old male presented with clinical features suggestive of solar urticaria. The diagnosis of solar urticaria and the effectiveness of a combination of H1 and H2 blocking antihistamines were confirmed by phototesting with a solar simulator |
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Sweet's syndrome |
p. 291 |
C Subhash Bharija, Gurmohan Singh PMID:20952992A series of 10 cases of Sweet's syndrome observed during a period of 3 years in Eastern parts of Libya is reported. All the patients were females. Fever and peripheral neutrophilia were not found in all these cases. Dapsone was found to be very effective in the cases in which it was tried. |
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Tuberous sclerosis : A three-generation pedigree |
p. 293 |
Srilekha Biswas, Kumar Alok Roy, Kuma Sadhan Ghosh PMID:20952993This is a report of tuberous sclerosis in members of three generations originating from parents, both suffering from the disease. Out of 12 family members only two were exempted and clinical expression varied from minimum lesion like adenoma sebaceum only to severe mental retardation and epilepsy |
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Incontinentia pigmenti |
p. 295 |
S Purohit, MK Singhi, R Khullar, G Kalla PMID:20952994Three cases of incontinentia pigmenti are reported. All the patients were female with bizarre pigmentation and verrucous and nodular lesions on the body. In all the cases there was absence of the vesicular stage and systemic involvement |
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CASE REPORTS |
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Keratoacanthoma centrifugum marginatum |
p. 297 |
S Rastogi, Pramod Kumar, K Swarup, Lalit Mohan, Mu PMID:20952995A case of 38-year-old male with multiple keratoacanthoma centrifugum marginatum is reported. Clinical presentation was in the form of multiple, firm, non-tender skin coloured nodules of variable sizes. Diagnosis was confirmed by the histopathological examination. The case is being reported because it is a rare variant of keratoacanthoma |
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Papuloerythroderma of ofuji |
p. 299 |
D Prasad, RK Gautam, HK Kar, RK Jain, M Bhardwaj PMID:20952996A 62-year old female had intensely pruritic eruption consisting of widespread coalescing sheets of uniform erythematous papules with characterstic sparing of body folds (deck-chair sign). Papuloerhthroderma of Ofuji is a rare disease of unknown aetiology |
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Pemphigus herpetiformis |
p. 301 |
Susan Varghese, George Soshamma, Mary Jacob, Chand PMID:20952997A 70-year old Indian lady with a two year history of a blistering eruption is described. This eruption clinically resembled dermatitis herepetiformis and responded to dapsone, however, histological and immunological investigations showed features of pemphigus herepetiformis |
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Lip leishmaniasis |
p. 303 |
S Criton, PK Sridevi, PU Asokan PMID:20952998A case of leishmaniasis of lip without any involvement of other parts of the body in a 36 year-old-male is described |
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Vesicular and bullous eruptions in tropical (filarial) eosinophilia |
p. 305 |
G Ramesh Kumar, M Kumaraswamy Reddy, R Premanand PMID:20952999A case of tropical (filarial) eosinophilia (TE) presented with vesicular and bullous eruptions. The patient had skin and mucosal blistering. Histopathological changes were that of bullous pemphigoid. The patient had very high eosinophilia with abnormal vacuoles in the cytoplasm. ELISA test was positive for filarial antibodies. There were no pulmonary signs or symptoms. X-ray chest was normal. The patient responded well to diethylcarbamazine |
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Vulval elephantiasis : A sequel to tubercular lymphadenitis |
p. 308 |
RC Sharma, P Gurvinder Thami, NL Sharma, As Sharma PMID:20953000Two cases of vulval elephantiasis arising as a sequel to complete destruction of regional lymph nodes of tubercular aetiology are described for its rarity |
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Cockayne's syndrome |
p. 310 |
K Krishna PMID:20953001A 10-year old boy, a product of consanguineous marriage was diagnosed clinically as a case of Cockayne's syndrome because of delayed milestones, deaf mutism with spastic paraplegia, dwarfism, salt and pepper fundus, typical facies and a photosensitive rash on the butterfly area of the face |
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Keratitis, ichthyosis and deafness (KID) syndrome |
p. 312 |
S Criton, Johny Vincent PMID:20953002Keratitis, ichthyosis, deafness (KID) syndrome is a genetically determined disorder. The present case is having marked photophobia, bilateral corneal ulceration with vascularisation, neurosensory deafness and skin changes |
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Atypical gorlin's syndrome |
p. 314 |
Devakar Yesudian, SGS Krishnan, Murgaiyy Jayaraman PMID:20953003A 21-year-old woman presented with complaints of skin lesions on her face, palms and soles. On examination, 8 to 10 well-defined, pigmented nodules with raised and pearly borders were seen on the face. Multiple pits were present on the palms and soles. Biopsy of both lesions revealed the presence of basal cell epitheliomas. The patient also gave history of removal of a keratocyst of mandible 10 years back. The case was diagnosed as Gorlin's syndrome. It is atypical due to the low number of basal cell epitheliomas, the occurrence of only a single odontogenic cyst and the absence of other features usually associated with this condition |
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Cutaneous B-cell lymphoma |
p. 317 |
M Jayaraman, VR Janaki, Patrick Yesudian PMID:20953004Primary cutaneous B-cell lymphoma is associated with poor prognosis. But with low grade pathology it may have a good prognosis. A 32-year-old man presented with hyperpigmented patches over chest which on biopsy showed perivascular infiltrate and was treated as vasculitis. After 8 months he came again with multiple nodules and plaques with ulceration. Biopsy of the plaque showed evidence of B-cell lymphoma. With chemotherapy the patient died after 6 months. Retrospective study of the earliest biopsy showed atypical lymphoid cells. This emphasizes the importance of the dermatopathological interpretation at the earliest stage |
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Erythropoietic protoporphyria (Report of three cases) |
p. 320 |
M Shafi, ML Khatri PMID:20953005Three Libyan patients developing clinical manifestations of erythropoietic protoporphyria (EPP) at 5 years, 7 years and 3 years of age are reported. All of them had variable degree of photosensitivity leading to pitted scarring. Red blood cells in peripheral blood smear revealed positive pink fluorescence in all. First patient responded well with chloroquine therapy and the 3rd patient showed improvement with oral beta-carotene therapy, but the second patient did not show significant response to either |
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Post-kala-azar Dermal Leishmaniasis with Atypical Presentation (le) |
p. 323 |
S Rathi, N Khanna, RK Pandhi |
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LETTER TO EDITOR |
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Autohaemotherapy in chronic urticaria |
p. 323 |
Adarsh Chopra, Mamta, Dimple Chopra PMID:20953006 |
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Scleredema |
p. 324 |
A Ghosh, SV Shah, JN Dave, NS Vora, K Roy, Cardoso PMID:20953008 |
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Kissing lupus vulgaris |
p. 325 |
M Devinder Thappa, BR Garg, C Ratnakar PMID:20953009 |
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Occurrence of squamous cell carcinoma and multiple cutaneous horns in porokeratosis |
p. 326 |
Devakar P Yesudian, SGS Krishnan, M Jayaraman, Jan PMID:20953011 |
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