Clinic incidence of neurosyphilis was found in about 5 percent cases of late syphilis during 1960-67. Not a single clinical early neurosyphilis was admitted during the above study period. Four were symptomatic and 157 were symptomatic neurosyphilis. Three of 161 were late congenital syphilitic. Parenchymatous involvement was markedly predominant (75 percent) so also the cerebral (60 percent) than spinal (38.2 percent). Duration of infection at the time of diagnosis was shortest (7.5 years) in meningeal and longest (17.6 years) in amyotrophy and retinochoroiditis. Inadequate treatment failed to protect from developing neurosyphilis. Reactive blood serology was found in all except one. Reactive spinal fluid was found in 41 (27 percent) out of 153 examined. Not a single case of reactive spinal fluid and non reactive blood was found. Satisfactory result with treatment was obtained in 12 only out of 150 treated. Maximum improvement was noted in the meningeal group and nil in advance cases of optic atrophy. Penicillin with steroid was considered better than penicillin alone in cases with symptoms of recent onset and in cases with highly abnormal spinal fluid.

Two cases of congenital ectodermal defect are presented showing the typical facies, soft skin and feminine hair distribution. Skin biopsy from the forearm and axillae showed absence of sweat, sebaceous and apocrine structures. Sweat function test with bromo-phenol was negative as compared with a control patient. Clinically patients were uncomfortable in the warm weather for which they used to control their body temperature with frequent cold water soaks. Nasal examination showed associated chronic atrophic rhinitis. Axillary and pubic hair were absent and examination of genitalia showed hypospadias in case 1. Dental abnormalities seen in case 1. In the upper teeth, 8 deciduous teeth were present and lower teeth four in number, the two central being permanent and the other two deciduous. In case 2 all teeth were absent and patient had an artificial denture.

A brief review of literature and a case of familial hypercholesterolemic xanthomatosis is discussed.

A total of 16 cases of Granuloma venereum were treated with Reverin. Seven of the cases were treated with Reverin 150 mg twice a day. Two of the 7 cases were resistant to streptomycin. All the cases responded uniformaly well to Reverin therapy. Nine of the cases were treated with a single injection of Reverin 150 mgm IM per day. Two of the nine cases were resistant to the streptomycin therapy. All the cases responded well to Reverin therapy.

In a controlled comparative study, the antihistaminic Tavegyl was found to have good antipruritic effect. In this series of 38 patients, the clinical response was good in 17 cases and fair in 16 cases. Only in 5 cases were the results poor. Tavegyl was very well tolerated and no adverse effects or toxic reactions were observed in this series. Tavegyl is no doubt a valuable addition to the available antihistminics with potent antihistaminic effect. It is especially effective in cases of eczematous dermatoses, superficial fungus infections with secondary eczematization, neurodermatitis, urticaria, angioneurotic oedema and essential pruritus.

Incidence of Donovanosis in the twin cities of Hyderabad and Secunderabad has been evaluated for six years period from 1962-1967. This part of Andhra Pradesh is not endemic for Donovanosis and the incidence is one of the lowest. The statistic for the period of two years 1966 and 1967 from Gandhi Hospital shows three-fold increase in the incidence of Donovanosis as compared to the incidence from Osmania General Hospital. Reasons for this disparity have been discussed. Two years is too short a period to take this disparity into consideration and so further study of Donovanosis for a longer period is indicated. This part of Andhra Pradesh being the state capital has become potentially susceptible for Donovanosis on account of the floating population. The study of Donovanosis apart from the reasons given will be welcome to the students of Donovanosis as such reports from other part of this subcontinent are few and far between and the need to evaluate this disease from other parts of India has been expressed by many authors.

Seventy cases of Lepra reaction were studied. Value of antimonials is stressed. Corticosteroid is very potent, but should be sparingly used for its frequent relapse, drug dependence, prohibitive cost and undesirable side-effects. Antimalarials have shown good result. Flagyl was found effective in only one case. it needs further trial. Capyna and placebo have not proved effective. Long acting sulfas have given good result and is worth trying.