Tachyphyla)ds to repeated application of clobetasol propionate under occlusion was demonstrated by the seventh day of the experiment on ten healthy volunteers using histamine induced wheal suppression technique.

Cell-me&ate,d immune (CMI) response to lepromin and dinitrochloro benzene (DNCB) was evaluatt-d in 60 freshly detected leprosy cases. It was observed that 70%, ( 28 of 40 ) of the pa across tie leprosy spectrum except LL cases revealed delayed hypersensitivity to DNCB as -against 42.5% (1-7 of 40) to lepromin. DNCB test was found superior to lepromin test to measure CMI because of its simplicity and easy interpretation of skin reactivity. It detected CMI in 40% of BL cases who were lepromin negative. Grading of skin reactivity showed a program decrease in delayed hypersensitivity across the spectrum of leprosy from TT to LL. It can be concluded that there is no gross impairment of non-specific CMI in leprosy patients other than LL cases and this non-specific CMI depression correlates well with Ridley-Jopling clinical scale of leprosy.

Cardio-vascular, autonomic functions were studied in 20 patients with lepromatous leprosy and 20 healthy adult controls Autonomic dysfunction was observed in the form of abnormal response in heart rate on standing 3 (15%) carotid artery pressure 7 (35%). Valsalva manoeuvre 5 (25%) and mental stress 3 (15%) in the leprosy patients. Response of blood pressure to standing and cold pressure test was seen in 2 (10%) and 7 (359o) patients respectively.

Detection of bacillemia in 40 untreated cases of leprosy was carried out by buffy coat. haemolysis and Petroff's concentration method. Bacillemiawas detected in 17 (42.5%) cases by Petroff's method. Out of 20 LL-BL cases, it was positive in 16 (80%) patients. Petroff's and haemolysis methods revealed bacillemia in 100% and 90% of LL cases respectively. The Petroff's method of concentration was found superior over the other techniques for better detection and quantitatioxi of bacffemia. A significant relationship between the bacillary load (BI) in the skin and the degree of bacillemia was observed especially in the lepromatous part of the spectrum of the dise4se.

Exposure time of sunlight for PUVASOL is often arbitrarily determined. This,can-lead to either inadequate or over-exposure,. We, have evolved a computer programme, from which the exposure time can be determined. The programme, takes into consideration the, variations of UV light at different times of the day. We hove to extend this pilot study to various places in India.

In India, contaneous leishmaniasis is confined to the western Thar desert. Epidemiologically, two different forms are seen, viz the rural and the urban forms. The vectors responsible for the transmission in this region are the Phlebotomus papatasi and the Sergentomyia clydei. The efficacy of oral dapsone was evaluated in the commonly existing sub-types of cutaneous leishmaniasis. Ten patients each of the nodular and ulcerative forms of cutaneous leishmaniasis were selected by strict 'clinical and pathological criteria and treated with oral dapsone in a dose of 2 mg per kg body weight daily, for 6 weeks. Seven patients of the nodular variety and all the ten patients in the ulcerative sub-group were cured. No major adverse effects were noted. Review after 6 months revealed no recurrence. in another ten patients taken as controls and not receiving the drug, the lesions showed no significant change.

An adult male developed a halo of leucoderma around a plaque of lichen planus on the leg. Development of perilesional leucoderma was followed by spontaneous regression of the central lesion of lichen planus. An autoimmune mechanism is suggested/in the pathogenesis of both lichen planus and vitilgo.

A 36 year old male had two, slowly increasing, asymptomatic, hard nodules on the scrotum without any preceding history of trauma, inflammation or any scrotal disease, for the last 8 years. Serum calcium and phosphorus levels were normal. Histopathology revealed calcified masses without any inflammatory reaction or epithelial lining.

A middle aged male had keratolysis exfoliative congenitum (continual skin peeling), since his infancy. None of his family members was affected by a similar skin disease. Mild rubbing of the skin with fingers caused rapid peeling of the horny layer. Oral vitamin A,50,000unitsdailyfortwomonthsand topical liquid paraffin were ineffective in controlling the desquamation.

A 29 year old patient, developed trichorrhexis nodosa of only the moustache at both its ends. There was no personal or family history of any hair, dermatological or central nervous system disorder. Also, there was no history of any previous topical or systemic therapy. In the absence of any other identifiable cause; his habit of repeated twirling of his moustache possibly resulted in trichorrhexis nodosa.

A 20 year old male started developing bubae following even minor trauma on the skin as well as the mucous membranes during the preceding 5 years. The bunae healed with atrophic scars. Involvement of the oral mucous membrane and the eyes, scpcially the right eye, was quite extensive and unusual. No other family member had similar complaint; neither was there association with any autoimmune or lymphoreticular disease.

A 32 years old male had dyskeratosis congenita with adenocarcinoma of stomach along with occurrence of carcinoma of stomch in four affected family members. The patient presented with progressive reticulate hyperigmentation of the face, neck, upper trunk and arms, hypopigmented macules, lacrimation and epigastric pain.

Dystrophic epidermolysis bullosa of Cockayne-Touraine type in a 37-year ole male