Fourteen cases of polymorphic light eruptions were investigated for any increase in porphyrin excretion. Ten out of these 14 patients showed increased excretion of porphyrins either in urine or faeces or both. Four out of this showed uroporphyrinuria. Two patients were observed to have uroporphyrinuria and coproporphyrinuria. In one of the patients uroporphyrin was found in detectable quantities in faeces as an isolated finding. In another patient in whom uroporphyrin was found in faeces, uroporphyrinuria and excessivequantities of protoporphyrin in faeces was found. In 2 more patients faecal coproporphyrin and protopoxphyrin were found to be increased.

Increased sweating on palms, soles and axillae is a very common problem. This paper describes various aetiological factors in the different types of hyperhidrosis. The role of autonomic nervous system and other factors in hyperhidrosis is discussed. Role of anxiety in causation of palmo-plantar hyperhidrosis is also discussed. Neurophysiological mechanism of anxiety involved in palmo-plantar hyperhidrosis is described.

In the present paper, three cases of erythema multiforme (EM) with depigmentation are recorded. The depigmentation is considered to be extremely rare. Depigmentation appeared after healing of the vesiculobullous and maculopapular type of eruption of EM. Depigmentation of the lesion occurred 4-8 months later with corticosteroid therapy. Erythema multiforme with depigmentation in a Negro girl has been reported by Bleier in 1958.

Eleven cases of tropicaloid ulcer have been described and diagnosis discussed. Role of treatment with broad spectrum antibiotics has been emphasise4 and protective measures to prevent their recurrence mentioned.

One of the serving soldiers was admitted to the Psychiatric wing of a Military Hospital in an acutely confused state. Investigations and observations confirmed the diagnosis of neurosyphilis and the therapeutic response was satisfactory. The case is reported as one with unusual manifestations of neurosyphilis.

A case of subcomeal pustular dermatosis of 16 years duration in a, 23 year old male patient is reported. The patient also had latent syphilis. He has responded well to dapsone therapy.

A case of scleredema occurring in old age with systemic manifestations in the form of electrocardiographic abnormalities with a review of literature is presented.

A case of basal cell nevus syndrome-Gorlins syndrome is presented. Its varied clinical manifestations and multi-organ system involvement are emphasised. Our case presented primarily with cutaneous manifestations i.e. multiple basal cell epitheliomas, multiple epithelial cysts and pitting of the palms. Systemic involvement was minimal. Mesenteric cysts were present. No osseous, neurologic, ophthalmic, reproductive or other manifestations were encountered.

Two cases showing essential features of Sjogren Larsson syndrome namely congenital ichthysiform erythrodermia, spastic disorders, mental retardation and speech defect arc presented. There was no history of consanguinity in parents. Macular dystrophy was present in one case. There was no history of convulsions in any of them. Bony age was almost consistent with their chronological agcs. Aminoaciduria was absent in both cases. There was no dental or osscous dysplasia in either case. Hyperteliorism, defective sweating or dermatoglyphy were not present in our cases. Additional findings in one case was presence of diabetes mellitus in the absenceof any family history of diabetes. Tuberculosis in some form or other was present in both cases Although this finding is not of much importance in our country where tuberculosis is commonly prevalent, it cannot be ignored that both patients are non-ambulatory and there is no case of tuberculosis among family members or near contacts.