Two cases of mycetoma caused by Madurella grisca are described. The diagnosis was established by histological structure of the grains and culture of the fungus. This is probably the first report of existence of mycetoma caused by M. grisca in Northern India.

The present report the marital status and some religious and onalfactors of male Bengalis and Paids who attended venereal (VD) clinics in England. In total 445 male Bengalis and Paids were interviewed. Of them 160 attended a VD clinic and formed the basis of the study. The remaining served as a control group.

Rhinosporidiosis is a disease caused by a fungus, Rhinosporidium seeberi. The disease is endemic in this area. On an average 75 patients per year report in DK Hospital, Raipur, Madhya Pradesh. The commonest site of the lesion is nose. In 10% of the cases the lesions is in the ocular tissues. Skin is also sometimes, involved. During the period 1967 to 1971 four cases of cutaneous sporidiosis were observed in this institution. The clinico-pathological, findings of these four cases are presented. Two cases were of satellite variety and the other two eperahzed cu s dissemination.

A case of epidermodysplasia verruciformis is presented. Empirical therapeutic trials with sulphaphenazole, dapsone and thiosemicarbazone failed to improve the lesions; however, response was obtained with 5 % salicylic acid ointment. Literature on its etiology has been briefly reviewed.

The purpose of this paper is to memoralize human achievement and pay tribute to mastery, the distinction of standing head and shoulders above, which in this heydey of the average, is still an inspiring thought. It is hoped that this story of scabies, however imperfectly told, may stimulate interest in those achievements of the past, which help us to solve the problems of the present and act as a foundation future progress.

Fifteen cases of acrodermatitis enteropathica, a rare disease, are reported from S M H S Hospital Srinagar. There were 8 males and 7 females. The criterion of diagnosis of this condition was the clinical picture of symmetrical vesiculo-pustular dermatitis, in upper and lower limbs and periorificial regions. Thirteen cases had variable degrees of diarrhoea, 10 were having glossitis and stomatitis, while 4 had conjunctivitis, blepharitis and chronic paronychia. These children had low body weight, were apathetic and irritable. Another additional diagnostic criterion he fairly prompt therapeutic response oral administration of quinoline derivatives. Only one case died during the period of observation, the child with severe trismus. This child was severely dehydrated and probably died of electrolyte imbalance. Two cases had a positive family history. Two of their siblings had suffered from similar disease. Two cases had no history of diarrhoea but had typical skin lesions and these responded to the quinolines without any supplementary systemic or topical medication. Apart from anaemia and ascariasis infestation in some of the cases other routine investigations were non-contributory.

Out of 79 patients there were 72 mates and 7 females. The youngest patient was aged 17 and the oldest was 58 years. More than 5 years duration was reported by 28 patients. Among the 79 patients only 21% (17) had the lesions confined to the "classical sites". Fifty two percent (41) had involvement of the front of the thighs in addition to the legs. Involvement of the thighs and forearms were seen in 22.8% (18), and facial involvement in addition to the above was seen in 3.8% (3). Scarring and atrophy showed certain preferential localization. The shiny appearance was mostly seen on the anterior and anterolateral aspects of the lower two third of the legs. On the lateral aspect of the calves and on the anterior aspects of the thighs numerous, well defined, small, depressed, roundish, atrophic scars; measuring 2-4 mm in diameter were seen in the place of the hairs. Subjective and objective aggravations were reported due to a variety of factors, ingestion of animal protein, alcoholic drinks, sleeplessness, contact with wet soil, excessive sweating, contact with cowdung and even sexual indulgence. Seasonal aggravation was reported by 66, of which 50.6% (40) were worse in summer, 20,2% (16) during winter and 12.6 (10%) during monsoon. All the cultures yielded coagulase positive staphylococci. Antibiogram (disc method) showed that the most effective antibiotic was streptomycin. Kanainycin, tetracyclines and chloramphenicol were also effective in vitro.

From the study of the four families of adenoma sebaceum, we have found that in two families the disease was transmitted in 3 to 4 generations, though it is mentioned by some authors that the transmission through more than 2 generations is rare. Though the characteristic features (skin lesions, mental retardation and epilepsy) of the syndrome are seen in two cases, forme fnaw are found in other members of ft same family. Curiously, we have found oneadult member of the family manifesting only epilepsy without any skin lesions which is rare, whereas two of the female members in the same genera'tion had the adenoma sebaceum with epilepsy and adenoma sebaceum respectively. This emphasizes that the ffim cardinal features may occur singly or in any combination or in any degree of severity in the members of the same family. In the above 4 cases, except for the features of epilepsy, mental retardation and adenoma sebaceum, no other skin manifestations were found.

It is possible to divide patients arbitrarily into three groups of "slow, moderate and rapid excretors" of dapsone on the basis of the estimation on the diazotizable material excreted by them in the urine during 24 hours following an oral dose of 100 mg of the drug. Thirty two lepromatous patients rendered bacteriologically negative after a prolonged treatment with DDS were studied with respect to the concentration in the blood and excretion in the urine of free as well as total DDS during the administration of standard dose of 100 mg of the drug daily. The findings are discussed. When the same patients were subjected to a test dose of 100 mg a study of their 24 hours urinary excretory pattern revealed that none of them belonged to the groups of 'rapid excretors'. However, in an attempt to correlate clinical improvement with the excretory pattern of DDS, it is stressed that the estimation of the drug in the tissues should be taken into consideration.