A group survey of gross deformities among 410 leprosy patients attending Leprosy treatment centre was done. The incidence of deformities observed 39.5 percent. Gross deformities are more in non-lepromatous type-27 per cent. The commonest deformity observed was claw hand. No case of wrist drop observed. Gross occular defects observed were only in eight lepers.

A case of congenital Keratoderma of palms and soles with benign hypertension, cerebro-vascular accident (thrombosis) and left ventricular strain is presented here in relation to other genodermatosis of similar types. Ten members of the same family were affected. Differential diagnosis is discussed.

Epidermolysis bullosa is a genodermatosis. This case was exhibiting all classical signs and the family history. Mucous membrane lesions are reported only in 20 percent of cases. In this particular case we saw mucous membrane changes on the hard palate which we did not come across in any of the reported cases.

The cases of syphilitic juxta articular nodes seen in the Mens Venereal Diseases Clinic, Government Erskine Hospital, Madurai are reported. The literature regarding the subject is reviewed.

Gangrenous balanitis occurring as a complication of venereal ulcers specially chancroid, is not uncommon in the venereal disease pratice in South India. Fusiform bacilli and non- syphilitic spirochetes can usually be isolated from such lesions. The following case, however, is of interest because phagedena, developing out of a clear sky without sexual exposure, involved the entire shaft penis within 12 days.

Two cases of Juvenile acanthosis nigricans without any complications are presented. Improvement of lesions with vitamin A is reported.

Twenty-two cases of discoid lupus erythematosus were studied for their porphyrin metabolic changes. The series included two groups: Group I showing only the skin lesions and group II in which the skin lesions were associated with some signs and symptoms indicative of systemic involvement. Group I showed more or less normal values. Two cases of group II showed high porphyrin levels while the other two showed normal values. It was suggested that the high porphyrins in these two cases were precipitated by lupus erythematosus in genetically predisposed individuals.