Epidermolysis builosa and its variants are reviewed in brief. Five cases of epidermolysis bullosa dystrophica observed in two families are reported. Mode of inheritance appears to be due to presence of recessive gene in homozygous state.

The three main groups of leprosy are tuberculoid, intermediate and lepromatous. Factors known to precipitate reactions in leprosy are diseases - like typhoid, malaria, dysentery, ankylostomiasis and influenza, diet, climatic changes, mental stress, small pox vaccination, late months of pregnancy, childbirth, drugs like sulphonamides, sulphur derivatives and iodides. The three types of reactions are 1) ALR 2) PLR 3)ENL. The treatment of reaction is firstly to stop DDS and substitute by diphenylthiourea (DPT). In case DPT is not available, DDS can be substituted by less toxic sulphones like promin or sulphetrone. Antibiotics and other drugs found useful are colchicoside, butazolidine and irgapyrine. Beneficial drugs whose use is empirical are methylene blue (MB), antimony compounds and adrenaline chloride if symptomatic treatment, MB etc fail to control reactions the only alternative is to use corticosteroids sparingly.

Serum copper levels were determined in normal individuals, cases of vitiligo and cases of hyperpiginentation using the technique of Gulber et al (1952). No significant alteration from normal in serum copper levels was observed neither in cases of vitiligo nor in cases of hyperpigmentation. The role of copper as a therapeutic agent in treatment of vitiligo is not supported. Further robe into this matter, may reveal some other factors responsible.

It is nearly impossible to distinguish between treponema pallidum and treponema pertenue. Differentiation between their histopathology is a relative one. Unfortunately these were not available during the present survey.

Twelve cases of yaws are described in Totapara area in Bengal amongst Totos.

Urine is a weak, detergent by virtue of its urea-content and this property is greatly enhanced when it is allowed to undergo bacterial fermentation. Such fermented urine has been used since time immemorial as a soap.