Clinical analysis, of 20 cases of systemic lupus erythematosus is presented. Familial incidence in which a brother and a sister got afflicted with this malady one after the other is reported, Attention is drawn to the protean clinical manifestations which the disease can assume. Fever and anaemia were the most common clinical features, being present in all the cases. Brunt of the disease next fell on joints, heart, respiratory tract, lymph-nodes, mucous-membrane and nervous system. Rash of almost all type is described in the literature except erythema multiforme, erythema-nodosum like lesions, and chronic ulceration on the legs were met with. Intractability of the ulceration of the mucous-membrane to steroid therapy is pointed out. Pericardium was more often the seat of involvement than myocardium and endocardium. Though the lesions assumed various types of radiological appearances when lung parenchyma was involved with this disease process, pathology seems to be mainly interstitial. Incidence of involvement of the nervous system in this series is also quite considerable i.e. nearly 32 %, the most common manifestation being psychotic symptoms.