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Year : 2019  |  Volume : 85  |  Issue : 1  |  Page : 44-50

Safety and efficacy of autologous noncultured dermal cell suspension transplantation in the treatment of localized facial volume loss: A pilot study

Alok Kumar Sahoo1, Savita Yadav1, Vinod K Sharma1, Anita Singh Parihar1, Surabhi Vyas2, Somesh Gupta1 
1 Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India
2 Department of Radiology, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Dr. Somesh Gupta
Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi
India

Background: Available options for correction of facial volume loss, such as synthetic fillers, autologous fat and cultured fibroblasts, have limitations viz. temporary effect and high cost. Aim: To assess the use of a novel technique, autologous non-cultured dermal cell suspension transplantation, for correction of localized facial volume loss due to inflammatory pathologies. Methods: It was a pilot study conducted in the Dermatology Outpatient Department, All India Institute of Medical Sciences (AIIMS), New Delhi, India. Autologous non-cultured dermal cell suspension was transplanted in a total of 10 patients, out of which 5 had predominantly dermal loss and the rest had predominantly lipoatrophy. The donor tissue from the gluteal region was digested into a single cell suspension using collagenase-1 and injected into the recipient area. The outcome was assessed subjectively by patients and investigators and objectively using ultrasonography. Cell count, viability testing and measurement of mesenchymal stem cells were also done. Results: On assessment of patients, the median improvement in the predominantly dermal atrophy group at 3 and 6 months was 70% (range: 10–90%) and 80% (range: 0–90%), respectively, and in the predominantly lipoatrophy group, 0% (range: 0–40) and 0% (range: 0–50), respectively. Mean thickness of dermis + subcutis at the baseline was 1.835 mm (range: 0.89–6.04 mm), which increased to 2.912 mm (range: 0.88–7.07 mm, P = 0.03) at 6 months. Limitations: Our pilot study has some limitations such as small sample size and heterogeneity of the recruited patients. Conclusions: Autologous non-cultured dermal cell suspension transplantation appears to be safe and effective in localized facial dermal defects because of inflammatory pathologies, but not effective in deeper defects.


How to cite this article:
Sahoo AK, Yadav S, Sharma VK, Parihar AS, Vyas S, Gupta S. Safety and efficacy of autologous noncultured dermal cell suspension transplantation in the treatment of localized facial volume loss: A pilot study.Indian J Dermatol Venereol Leprol 2019;85:44-50


How to cite this URL:
Sahoo AK, Yadav S, Sharma VK, Parihar AS, Vyas S, Gupta S. Safety and efficacy of autologous noncultured dermal cell suspension transplantation in the treatment of localized facial volume loss: A pilot study. Indian J Dermatol Venereol Leprol [serial online] 2019 [cited 2020 Feb 29 ];85:44-50
Available from: http://www.ijdvl.com/article.asp?issn=0378-6323;year=2019;volume=85;issue=1;spage=44;epage=50;aulast=Sahoo;type=0


 

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