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Year : 2017  |  Volume : 83  |  Issue : 1  |  Page : 27-32

Topical sirolimus for the treatment of angiofibromas in tuberous sclerosis

Salih Levent Cinar1, Demet Kartal1, Ayşe Kacar Bayram2, Mehmet Canpolat2, Murat Borlu1, Ayten Ferahbas1, Hüseyin Per2 
1 Department of Dermatology and Venereology, Erciyes University Faculty of Medicine, Kayseri, Turkey
2 Department of Pediatric Neurology, Erciyes University Faculty of Medicine, Kayseri, Turkey

Correspondence Address:
Salih Levent Cinar
Erciyes University Faculty of Medicine, Dermatology and Venereology Department, Talas, Kayseri
Turkey

Background: The skin is one of the most affected organs in tuberous sclerosis complex and angiofibromas are seen in almost 80% of such patients. These benign tumors impose a great psycho-social burden on patients. Objective: The aim of the study was to evaluate the effectiveness and tolerability of topical sirolimus for facial angiofibromas in patients with tuberous sclerosis complex. Methods: This was a prospective, single-blinded, cross-over study which involved twelve patients. We investigated the effect and safety of topical 0.1% sirolimus, which was obtained by crushing sirolimus tablets and mixing it with petrolatum. The patients were asked to apply the cream to one side of their face, and vaseline to the other side. The effect of topical sirolimus was evaluated using the “facial angiofibroma severity index.” Results: There was a significant improvement in the redness and extension of the tumors on the sides to which the active ingredient was applied. Some side effects such as itching and irritation occurred in three patients, which were treated with topical hydrocortisone cream. Conclusion: Topical sirolimus appears to be a promising, fairly well tolerated treatment for facial angiofibromas in patients with tuberous sclerosis complex. Although its efficacy diminishes with time, repetitive usage is effective.


How to cite this article:
Cinar SL, Kartal D, Bayram AK, Canpolat M, Borlu M, Ferahbas A, Per H. Topical sirolimus for the treatment of angiofibromas in tuberous sclerosis.Indian J Dermatol Venereol Leprol 2017;83:27-32


How to cite this URL:
Cinar SL, Kartal D, Bayram AK, Canpolat M, Borlu M, Ferahbas A, Per H. Topical sirolimus for the treatment of angiofibromas in tuberous sclerosis. Indian J Dermatol Venereol Leprol [serial online] 2017 [cited 2020 Sep 19 ];83:27-32
Available from: http://www.ijdvl.com/article.asp?issn=0378-6323;year=2017;volume=83;issue=1;spage=27;epage=32;aulast=Cinar;type=0


 

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