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Year : 2014  |  Volume : 80  |  Issue : 6  |  Page : 526-529

Peripheral T-cell lymphoma at the injection site of influenza vaccination

Xin-ling Bi1, Yan-fang Liu2, Miao-xia He3, Jun Gu1 
1 Department of Dermatology, Changhai Hospital, Second Military Medical University, Shanghai, China
2 Department of Dermatology, Outpatient Clinic, Changhai Hospital, Second Military Medical University, Shanghai, China
3 Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai, China

Correspondence Address:
Jun Gu
Department of Dermatology, Changhai Hospital, Second Military Medical University, Shanghai
China
Miao-xia He
Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai
China

Pseudolymphomas or B-cell lymphoma at the vaccination site have been reported by several authors. However, onset of cutaneous T-cell lymphoma with cytotoxic features is a rare complication of vaccination. We report a 27-year-old man who developed a nodule and ulcer that arose at the site of injection of influenza vaccine. The neoplastic cells reacted positively for CD56, CD3, CD2, perforin, and granzyme B, but negatively for CD4, CD8, CD10, CD19, CD30, CD34, CD79, and betaF1. Molecular studies showed T-cell receptor γ (TCR-γ) chain monoclonal rearrangement. A diagnosis of peripheral T-cell lymphoma, not otherwise specified (NOS) was established. The patient had high fever, progressive liver dysfunction and a rapid fatal evolution.


How to cite this article:
Bi Xl, Liu Yf, He Mx, Gu J. Peripheral T-cell lymphoma at the injection site of influenza vaccination .Indian J Dermatol Venereol Leprol 2014;80:526-529


How to cite this URL:
Bi Xl, Liu Yf, He Mx, Gu J. Peripheral T-cell lymphoma at the injection site of influenza vaccination . Indian J Dermatol Venereol Leprol [serial online] 2014 [cited 2020 Jul 13 ];80:526-529
Available from: http://www.ijdvl.com/article.asp?issn=0378-6323;year=2014;volume=80;issue=6;spage=526;epage=529;aulast=Bi;type=0


 

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