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Year : 2011  |  Volume : 77  |  Issue : 4  |  Page : 477-482

Chronic urticaria in patients with autoimmune thyroiditis: Significance of severity of thyroid gland inflammation

Mustafa Gulec1, Ozgur Kartal1, A Zafer Caliskaner1, Mahmut Yazici2, Halil Yaman3, Sami Ozturk4, Osman Sener1 
1 Department of Internal Medicine, Division of Allergy, Ankara, Turkey
2 Department of Internal Medicine, Division of Endocrinology, Ankara, Turkey
3 Department of Biochemistry, Ankara, Turkey
4 Department of Internal Medicine, Division of Allergy, Haydarpasa Training Hospital, Istanbul, Turkey

Correspondence Address:
Ozgur Kartal
GATA Allerjik Hastaliklar BD, Etlik, Ankara
Turkey

Background: There is a clear association between autoimmune thyroiditis (AT) and chronic urticaria/angioedema (CUA). However, not all patients with AT demonstrate urticaria. Aims: The aim of the study was to investigate in which patients with AT did CUA become a problem. A sensitive inflammation marker, neopterine (NP) was used to confirm whether the severity of inflammation in the thyroid gland was responsible for urticaria or not. Methods: Neopterine levels were assessed in patients with AT with urticaria and without urticaria. Furthermore, levels were compared in relation to pre and post levothyroxine treatment. Twenty-seven patients with urticaria (Group 1) and 28 patients without urticaria (Group 2) were enrolled in the study. A course of levothyroxine treatment was given to all patients, and urine neopterine levels before and after the trial were obtained. Results: All patients completed the trial. Mean age in Group 1 and Group 2 was similar (35.70 ± 10.86 years and 38.36 ± 10.38 years, respectively) (P=0.358). Pre-treatment urine neopterine levels were significantly higher in Group 1 (P=0.012). Post-treatment levels decreased in each group, as expected. However, the decrease in the neopterine level was insignificant in the patients of Group 2 (P=0.282). In Group 1, a significant decrease in post-treatment neopterine levels (P=0.015) was associated with the remission of urticaria. Conclusion: In patients with CUA and AT, pre-treatment elevated levels of NP, and its decrease with levothyroxine treatment along with symptomatic relief in urticaria, may be evidence of the relationship between the degree of inflammation in thyroid and presence of urticaria.


How to cite this article:
Gulec M, Kartal O, Caliskaner A Z, Yazici M, Yaman H, Ozturk S, Sener O. Chronic urticaria in patients with autoimmune thyroiditis: Significance of severity of thyroid gland inflammation.Indian J Dermatol Venereol Leprol 2011;77:477-482


How to cite this URL:
Gulec M, Kartal O, Caliskaner A Z, Yazici M, Yaman H, Ozturk S, Sener O. Chronic urticaria in patients with autoimmune thyroiditis: Significance of severity of thyroid gland inflammation. Indian J Dermatol Venereol Leprol [serial online] 2011 [cited 2019 Aug 20 ];77:477-482
Available from: http://www.ijdvl.com/article.asp?issn=0378-6323;year=2011;volume=77;issue=4;spage=477;epage=482;aulast=Gulec;type=0


 

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