IJDVL Home  
 

ORIGINAL ARTICLE
[View FULLTEXT] [Download PDF]  
Year : 2011  |  Volume : 77  |  Issue : 2  |  Page : 141-147

Clinical and bacteriological profile and outcome of sepsis in dermatology ward in tertiary care center in New Delhi

DP Asati1, VK Sharma1, S Khandpur1, GC Khilnani2, A Kapil3 
1 Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi 110 029, India
2 Department of Medicine, All India Institute of Medical Sciences, New Delhi 110 029, India
3 Department of Microbiology, All India Institute of Medical Sciences, New Delhi 110 029, India

Correspondence Address:
V K Sharma
Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi 110 029
India

Background: There is paucity of data regarding the clinical and bacteriological profile of sepsis in dermatology in-patients. Aims: To study the frequency, etiology, and outcome of sepsis dermatology in-patients. Methods: The study was conducted in a 30-bedded dermatology ward of a tertiary care center. Sepsis was defined by presence of ≥2 SIRS (systemic inflammatory response syndrome) criteria along with evidence of infection (clinically obvious/culture proven infection of skin or internal organs). Patients were also assessed for known (common) risk factors of sepsis. In suspected sepsis patients, at least two samples of blood cultures by venepuncture were taken. Pus, skin swab, urine, and sputum samples were also collected for culture as needed with avoidance of contamination. Results: Among 860 admitted patients studied from November 2004 to July 2006, 103 (12%) fulfilled SIRS criteria. Of these, 63 had nonsepsis causes of SIRS positivity, while 40 (4.65%) had sepsis. Majority of the sepsis patient had vesicobullous diseases (42.5%), erythroderma (25%), toxic epidermal necrolysis (TEN) (22.5%). Severe sepsis developed in 17 (42.5%) patients, while 15 (37.5%) died. Methicillin-resistant Staphylococcus aureus (MRSA) was the commonest organism isolated (99; 25.9%) in all culture specimens followed by Acinetobacter spp. (52; 13.6%), Pseudomonas spp. (40; 10.5%), Methicillin-sensitive S. aureus (MSSA: 33; 8.7%), and Klebsiella spp. (22; 5.8%). Various risk factors affecting mortality and sensitivity patterns for various isolates were also analyzed. Conclusion: Sepsis occurred in 40 (4.65%) inpatients in dermatology ward. The frequency of sepsis was highest in TEN (90%), followed by drug-induced maculopapular rash (20.0%), erythroderma (17.5%), and vesicobullous diseases (8.5%). MRSA, acinetobacter, pseudomonas, MSSA, and Klebsiella were important etiological agents involved in sepsis in dermatology in-patients.


How to cite this article:
Asati D P, Sharma V K, Khandpur S, Khilnani G C, Kapil A. Clinical and bacteriological profile and outcome of sepsis in dermatology ward in tertiary care center in New Delhi.Indian J Dermatol Venereol Leprol 2011;77:141-147


How to cite this URL:
Asati D P, Sharma V K, Khandpur S, Khilnani G C, Kapil A. Clinical and bacteriological profile and outcome of sepsis in dermatology ward in tertiary care center in New Delhi. Indian J Dermatol Venereol Leprol [serial online] 2011 [cited 2020 Jul 14 ];77:141-147
Available from: http://www.ijdvl.com/article.asp?issn=0378-6323;year=2011;volume=77;issue=2;spage=141;epage=147;aulast=Asati;type=0


 

Tuesday, July 14, 2020
 Site Map | Home | Contact Us | Feedback | Copyright and disclaimer