IJDVL Home  
 

BRIEF REPORT
[View FULLTEXT] [Download PDF]  
Year : 2008  |  Volume : 74  |  Issue : 6  |  Page : 628-631

Topical immunotherapy with diphenylcyclopropenone in vitiligo: A preliminary experience

Shahin Aghaei1, Gholamreza Safaee Ardekani2 
1 Department of Dermatology, Jahrom University of Medical Sciences, Jahrom, Iran
2 Department of Dermatology, Jahrom University of Medical Sciences, Jahrom; Education Development Center, School of Medicine, Shiras University of Medical Sciences, Shiraz, Iran

Correspondence Address:
Shahin Aghaei
Department of Dermatology, Jahrom University of Medical Sciences, School of Medicine, Jahrom
Iran

Background: Despite recent significant therapeutic advances, vitiligo remains a clinical conundrum. Topical immunotherapy has been extensively tested in the treatment of various dermatologic disorders, especially those believed to have an immunologic basis. Aim: To evaluate the role of topical diphenylcyclopropenone (DPCP) in the treatment of vitiligo. Methods: Nineteen patients with limited vitiligo lesions were enrolled in this study. After sensitization with 2% lotion of DPCP in acetone, progressively higher concentrations beginning at 0.001% up to 2% were applied weekly for 6 months to the depigmented skin lesions. Results: Thirteen of the 19 patients were evaluated at the end of 6 months. Four patients with focal vitiligo, one patient with vitiligo vulgaris, and three patients with segmental vitiligo showed marked (grade 3) repigmentation. Conclusion: Marginal and central repigmentation with hyperpigmented borders was seen in the majority of lesions. Further controlled trials should be undertaken to evaluate the use of topical DPCP in vitiligo.


How to cite this article:
Aghaei S, Ardekani GS. Topical immunotherapy with diphenylcyclopropenone in vitiligo: A preliminary experience.Indian J Dermatol Venereol Leprol 2008;74:628-631


How to cite this URL:
Aghaei S, Ardekani GS. Topical immunotherapy with diphenylcyclopropenone in vitiligo: A preliminary experience. Indian J Dermatol Venereol Leprol [serial online] 2008 [cited 2020 Sep 28 ];74:628-631
Available from: http://www.ijdvl.com/article.asp?issn=0378-6323;year=2008;volume=74;issue=6;spage=628;epage=631;aulast=Aghaei;type=0


 

Monday, September 28, 2020
 Site Map | Home | Contact Us | Feedback | Copyright and disclaimer