IJDVL Home  
 

STUDIES
[View FULLTEXT] [Download PDF]  
Year : 2005  |  Volume : 71  |  Issue : 3  |  Page : 175-178

A study of serum nitric oxide levels in psoriasis

Neeta R Gokhale1, Vasudha A Belgaumkar1, Dakshayani P Pandit2, Shantanu Deshpande2, Dhananjay K Damle1 
1 Departments of Skin and STD, B. J. Medical College and Sassoon General Hospitals, Pune, India
2 Departments of Microbiology, B. J. Medical College and Sassoon General Hospitals, Pune, India

Correspondence Address:
Neeta R Gokhale
39/30, Smruti, Lane 9, Prabhat Road, Pune - 411004
India

BACKGROUND: M any inter and intracellular mediators have been implicated in the pathogenesis of psoriasis. Nitric oxide has been shown to play an important role in many diseases. Previous studies have demonstrated raised levels of nitric oxide in psoriatic plaques which may be attributed to its effect on keratinocytes, on local cGMP levels or its ability to induce angiogenesis. AIMS: To detect serum nitric oxide (NO) levels in patients with active psoriasis, to correlate these levels with severity of disease and compare them with those in normal individuals. METHODS: Thirty six patients with active psoriasis were selected after written consent. All patients on topical or systemic treatment for fifteen days prior to the study were excluded. Disease severity was assessed by PASI score and serum nitric oxide levels were detected by Greiss method and compared with age and sex matched controls. Statistical analysis of all data was done by unpaired t test. RESULTS: Out of 36 patients, 30 had chronic plaque psoriasis (mean NO 157.5), 4 had erythroderma (mean NO 120.2) and 2 had generalized pustular psoriasis (mean NO 144.3). The mean NO level in the psoriatic group was 157.7 with SD 50.4 while in the control group it was 32.8 with SD 4.03. The difference was statistically significant (t=13.8, P <0.001). In the chronic plaque group, as the duration of disease increased, the NO levels increased significantly. CONCLUSIONS: Nitric oxide levels were significantly increased in patients with psoriasis and these levels showed a positive correlation with severity and duration in the chronic plaque type group.


How to cite this article:
Gokhale NR, Belgaumkar VA, Pandit DP, Deshpande S, Damle DK. A study of serum nitric oxide levels in psoriasis.Indian J Dermatol Venereol Leprol 2005;71:175-178


How to cite this URL:
Gokhale NR, Belgaumkar VA, Pandit DP, Deshpande S, Damle DK. A study of serum nitric oxide levels in psoriasis. Indian J Dermatol Venereol Leprol [serial online] 2005 [cited 2019 Nov 17 ];71:175-178
Available from: http://www.ijdvl.com/article.asp?issn=0378-6323;year=2005;volume=71;issue=3;spage=175;epage=178;aulast=Gokhale;type=0


 

Sunday, November 17, 2019
 Site Map | Home | Contact Us | Feedback | Copyright and disclaimer