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Year : 1995  |  Volume : 61  |  Issue : 6  |  Page : 386

Jarisch-Herxheimer reaction in early syphilis

Gurcharan Singh, YP Jalpota 

Correspondence Address:
Gurcharan Singh

How to cite this article:
Singh G, Jalpota Y P. Jarisch-Herxheimer reaction in early syphilis.Indian J Dermatol Venereol Leprol 1995;61:386-386

How to cite this URL:
Singh G, Jalpota Y P. Jarisch-Herxheimer reaction in early syphilis. Indian J Dermatol Venereol Leprol [serial online] 1995 [cited 2019 Dec 10 ];61:386-386
Available from: http://www.ijdvl.com/text.asp?1995/61/6/386/4291

Full Text

 To the Editor,

This is with reference to letter to the editor 'Febrile herxheimer reaction' (Ind J Dermatol Venereol Leprol 1995; 61:180-1). We wish to share our experience of a similar study whereupon clinical, haematological and histological features of J-H reaction were studied in 50 cases of early syphilis after penicillin therapy.[1] J-H reaction was observed in 40% of patients with primary syphilis, 70% and 33% of patients with secondary and early latent syphilis respectively. The febrile response followed a uniform temporal pattern with height of fever as chief variable being highest in patients with early manifestations of secondary syphilis. Polymorphonuclear leukocytosis and raised ESR were detected in 37% and 88% of cases with J-H reaction. Subepidermal oedema, dilated blood vessels with endothelial prominence and perivascular round cell infiltration were the consistent histological features of cutaneous reaction.


1Singh G, Jalpota YP: Jarisch-Herxheimer reaction in early syphilis. Indian J Sex Transm Dis 1992;13:57-9.


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