|Year : 1993 | Volume
| Issue : 2 | Page : 86-87
Poikilodermatous mycosis fungoides
P Ratnavelu, D Prabhavathy, M Sundaram, S Sugantha
A 55-year old male presenting with itching, pigmentation and atrophy confirmed histopathologically as mycosis fungoides is reported for its peculiar manifestation.
|How to cite this article:|
Ratnavelu P, Prabhavathy D, Sundaram M, Sugantha S. Poikilodermatous mycosis fungoides.Indian J Dermatol Venereol Leprol 1993;59:86-87
|How to cite this URL:|
Ratnavelu P, Prabhavathy D, Sundaram M, Sugantha S. Poikilodermatous mycosis fungoides. Indian J Dermatol Venereol Leprol [serial online] 1993 [cited 2020 Sep 18 ];59:86-87
Available from: http://www.ijdvl.com/text.asp?1993/59/2/86/3893
Poikiloderma denotes pigmentation, telangiectasis and atrophy of the skin. These changes could occur in very many dermatological disorders like Rothmund Thompson syndrome, dermatomyositis, lupus erythematosus and mycosis fungoides. This interesting manifestation occurring in mycosis fungoides is reported herewith.
A man aged 55 years was admitted for skin lesion, mottled pigmentation, telangiectasis and atrophy [Figure 1] with the complaints of generalised itching, burning sensation and general weakness. The skin lesions started 3 years back as erythematous scaly lesions over the chest, back, subsequently covering the extremities and face.
The existing skin lesions progressed gradually to poikilodermatous changes, followed by pigmentation over the face in 1 year. Mucous membrane, skin appendages were normal. Axillary and inguinal lymphadenopathy was present - discrete, not tender. Systemic examination revealed no abnormalities.
Investigations were as follows Haematological : leucocytosis with anaemia, Sezary cell, antinuclear factor, Elisa test (HIV) - negative, Blood VDRL - non-reactive, Bone marrow, G. I. endoscopy, ultrasound and scan - normal study,. Liver and Muscle biopsy - normal study, Skin biopsy - epidermis atrophic, dark stained large mononuclear cells in dermis, epidermodermal junction and invading epidermis surrounded by a halo compatible with mycosis fungoides [Figure 2]. Gland biopsy - dermatopathic lymph adenopathic picture.
A diagnosis of poikilodermatous mycosis fungoides was made on the basis of clinical and histopathological findings.
Poikilodermatous mycosis fungoides is a variety of mycosis fungoides belonging to T-cell lymphoma. Of the various stages described in mycosis fungoides, pre-reticulotic, plaque and tumour stages, the eventual progression of the disease which would follow one after another, or at times, the later stages appearing as the first manifestation of the disease. The ''poikilodermatous type" is mentioned to occur in the prereticulotic stage with distribution over trunk and extremities with itching and burning sensation. 
The histopathological features of skin described are atrophy of epidermis, dense, large, deeply stained mononuclear cells in dermis, close to epidermodermal junction and invading epidermis.
|1||Samman PD. Natural history of parapsoriasis en plaque and prereticulotic poikiloderma. Br J Dermatol 1972; 84: 405-11.|