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Year : 1984  |  Volume : 50  |  Issue : 4  |  Page : 142-143

Vincristine Sulphate Induced Ectodermal Dysplasias Chick Embryos

Arunachalam Kumar 
 

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Two hundred and forty nine eggs of the white leghorn were injected on day 3,4 and 5 their incubation, with 0.03 mgtkg egg weight, of vincristine sulphate. Most embryos were removed 24, 48 and 72 hours after administration and examined histologically. A few eggs were opened on day 18 of incubation. The results of this study indicate that the drug is embryo-lethal in a majority of chicks and those that survive the toxic effects of vincristine show pronounced neuro/ectodermal dysplasias. Malformations of the neural tube and neural crest with depigmentation of the feathers and their loose anchoring were observed. The possible mechanism of these dysplasias is discussed.


How to cite this article:
Kumar A. Vincristine Sulphate Induced Ectodermal Dysplasias Chick Embryos.Indian J Dermatol Venereol Leprol 1984;50:142-143


How to cite this URL:
Kumar A. Vincristine Sulphate Induced Ectodermal Dysplasias Chick Embryos. Indian J Dermatol Venereol Leprol [serial online] 1984 [cited 2020 Sep 27 ];50:142-143
Available from: http://www.ijdvl.com/article.asp?issn=0378-6323;year=1984;volume=50;issue=4;spage=142;epage=143;aulast=Kumar;type=0


 

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