Indexed with PubMed and Science Citation Index (E) 
Users online: 3484 
     Home | Feedback | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe What's New Contact  
Ahead of Print

Lack of association of IL-10 (rs1800896) and IL-13 (rs1800925) with non-segmental vitiligo susceptibility in South Indian population

1 Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
2 Department of Dermatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
3 Department of Unit of Microbiology and Molecular Biology, Indian Council of Medical Research-Vector Control Research Centre, Puducherry, India

Correspondence Address:
Medha Rajappa,
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry - 605 006
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijdvl.IJDVL_124_19

PMID: 32295963

Background: Vitiligo is an autoimmune depigmentation disorder caused by multiple etiologies. Genetic polymorphisms in cytokine genes influence their expression and augment disease development. Analyzing the influence of genetic polymorphisms will help in better understanding of the complex etiopathogenesis of vitiligo Aim: To study the influence of interleukin IL-10(rs1800896) and IL-13(rs1800925) polymorphisms on vitiligo risk in South Indian population. Methods: Two hundred and sixty-four vitiligo patients and 264 controls were recruited in this study. Genotyping was done by quantitative PCR and plasma cytokine levels were measured by ELISA. Results: Allele frequencies of IL-10(rs1800896) and IL-13(rs1800925) SNPs were observed to be equal in the groups. Mutant allele G of IL-10(rs1800896) enhanced the familial inheritance of vitiligo (P < 0.0001, OR-25.1, 95% CI-7.64–82.7) and influenced the development of vulgaris type of vitiligo (P = 0.034, OR-1.83, 95% CI-1.07–3.13). Ancestral allele A of IL-10(rs1800896) conferred protection against development of acrofacial vitiligo (P = 0.04, OR-0.56, 95% CI-0.33–0.95). Circulatory IL-10 levels in vitiligo patients were higher than controls (P < 0.0001). Individuals with genotype GG of IL-10(rs1800896) had the highest circulatory levels of IL-10 (P < 0.0001). Among the genotypes of IL-13(rs1800925) variant, none influenced the phenotype of nonsegmental vitiligo such as gender, family history, age of onset and types of vitiligo (P > 0.05). In addition, no difference was noted in the circulatory levels of IL-13 between patients and controls (P = 0.48). Within patients, CC genotype of IL-13(rs1800925) was observed to enhance the circulatory IL-13 levels (P < 0.0001). Limitation: Replication group analysis in a larger multicentric cohort in future would validate further understanding of vitiligo susceptibility in South Indian ethnics. Conclusion:IL-10(rs1800896) and IL-13(rs1800925) polymorphisms did not confer risk to develop vitiligo in South Indian population.

Print this article
  Search Pubmed for
    -  Rajendiran KS
    -  Rajappa M
    -  Chandrashekar L
    -  Thappa D M
    -  Devaraju P
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded1027    

Recommend this journal

Online since 15th March '04
Published by Wolters Kluwer - Medknow