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Year : 2020  |  Volume : 86  |  Issue : 2  |  Page : 178-180

Dome-shaped solitary nodule


Department of Dermatopathology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu Province, China

Date of Web Publication19-Sep-2018

Correspondence Address:
Dr. Xiaofang Li
Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 12, Jiangwangmiao Street, Nanjing 210 042, Jiangsu Province
China
Dr. Yiqun Jiang
Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 12, Jiangwangmiao Street, Nanjing 210 042, Jiangsu Province
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijdvl.IJDVL_439_17

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How to cite this article:
Zhang W, He Y, Li X, Jiang Y, Zeng X, Liu W, Sun J. Dome-shaped solitary nodule. Indian J Dermatol Venereol Leprol 2020;86:178-80

How to cite this URL:
Zhang W, He Y, Li X, Jiang Y, Zeng X, Liu W, Sun J. Dome-shaped solitary nodule. Indian J Dermatol Venereol Leprol [serial online] 2020 [cited 2020 Apr 2];86:178-80. Available from: http://www.ijdvl.com/text.asp?2020/86/2/178/241562

*Wei Zhang, Yun He: These authors contributed equally to this paper.




A 64-year-old, otherwise healthy woman was referred to our hospital with a 3-year history of an asymptomatic lesion on the medial aspect of her right leg.

Physical examination disclosed a dome-shaped, firm, reddish-brown, solitary nodule, approximately 3 cm in diameter [Figure 1]a. She had no previous significant medical or surgical history or a family history of such a tumor. Histopathology showed an unencapsulated, well-circumscribed tumor in the upper to mid dermis. The tumor was composed of multiple, oval to irregularly-shaped, tubular structures lined by two or more layers of epithelial cells and surrounded by fibrous stroma [Figure 1]b. The luminal layers were composed mainly of cuboidal cells forming papillary projections in some tubules [Figure 1]c. The peripheral layer was lined with flattened to cuboidal cells. Neither decapitation secretions nor connection of the neoplastic tubules to the overlying epidermis were seen. The overlying epidermis was slightly atrophied. Within some tubules, eosinophilic amorphous material was noted. Cell necrosis, mitosis and nuclear pleomorphism were absent. Immunostaining revealed positivity for cytokeratin-7 [Figure 1]d. Positive staining with epithelial membrane antigen highlighted the tumor cell membranes [Figure 1]e. The inner epithelial cells were partly positive for carcinoembryonic antigen. Gross cystic disease fluid protein-15 was negative in tumor cells.


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Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient has given her consent for her images and other clinical information to be reported in the journal. The patient understands that name and initials will not be published and due efforts will be made to conceal identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

This work was supported by the Fundamental Research Funds for the Central Universities (2016RC320006) and the CAMS Innovation Fund for Medical Sciences (CIFMS-2017-I2M-1-017).

Conflicts of interest

There are no conflicts of interest.



 
  References Top

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LeBoit PE, Burg G, Weedon D, Sarasin A. World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours. Lyon, France: IARC Press; 2006.  Back to cited text no. 1
    
2.
Blasini W, Hu S, Gugic D, Vincek V. Papillary eccrine adenoma in association with cutaneous horn. Am J Clin Dermatol 2007;8:179-82.  Back to cited text no. 2
    
3.
Tellechea O, Reis JP, Marques C, Baptista AP. Tubular apocrine adenoma with eccrine and apocrine immunophenotypes or papillary tubular adenoma? Am J Dermatopathol 1995;17:499-505.  Back to cited text no. 3
    
4.
Mizuoka H, Senzaki H, Shikata N, Uemura Y, Tsubura A. Papillary eccrine adenoma: Immunohistochemical study and literature review. J Cutan Pathol 1998;25:59-64.  Back to cited text no. 4
    
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Ichikawa E, Okabe S, Umebayashi Y, Iijima S, Otsuka F, Watanabe S, et al. Papillary eccrine adenoma: Immunohistochemical studies of keratin expression. J Cutan Pathol 1997;24:564-70.  Back to cited text no. 5
    


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